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Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction. [PDF]

Elife
Gao X, Guo W, Liu P, Yuwen M, Ren H, Hu S, Liu Z, Tan R, Liu K, Yang Z, Ba J, Bai X, Shama S, Tang C, Miao K, Pei H, Liu L, Zhu C, Wang T, Zhang B, Kang J.   +20 more
europepmc   +1 more source

Salvianolic acid B mitigates senescence and promotes osteogenesis of senescent bone marrow mesenchymal stem cells via the PI3K/AKT pathway. [PDF]

Biochem Biophys Rep
Zhong S, Wu D, Chen Q, Zeng C, Chen H, Huang J.   +5 more
europepmc   +1 more source

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Complement Factor H related protein 1 and immune inflammatory disorders

Molecular Immunology, 2022
Human complement Factor H-related protein 1 (FHR-1) is one of complement Factor H-related proteins (FHRs) and plays an important role in innate immunity. In particular, FHR-1 promotes complement activation by competing with Factor H (FH) for ligands on different surfaces or directly binding to C3b and native C3.
Xiangru, Li, Jing, Zong, Shaoyan, Si
openaire   +2 more sources

Complement factor H related proteins in immune diseases

Vaccine, 2008
The complement system is a powerful part of the host innate immune defense and is aimed to damage and eliminate microbes and modified self-cells. To protect host cells and biological surfaces from damage mediated by complement activation products a tight control of the complement system is necessary.
Christine, Skerka, Peter F, Zipfel
openaire   +2 more sources

HUMAN COMPLEMENT FACTOR H RELATED PROTEIN TEST FOR MONITORING BLADDER CANCER

Journal of Urology, 2001
The BTA stat test is a rapid, noninvasive, qualitative urine test that detects bladder tumor associated antigen (human complement factor H related protein) in urine. We compared BTA stat test to voided urine cytology in patients monitored for bladder cancer in a prospective trial, and determined whether this test is effective in detection of recurrence
M P, Raitanen, T, Marttila, M, Nurmi, M, Ala-Opas, P, Nieminen, R, Aine, T L, Tammela   +6 more
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Biochemical and functional characterization of the factor-H-related protein 4 (FHR-4)

Immunopharmacology, 1997
Factor-H-related proteins and the complement regulatory protein factor H represent a family of structurally and immunologically related plasma proteins. The function of the various factor-H-related proteins are currently unclear and under investigation.
J, Hellwage, C, Skerka, P F, Zipfel
openaire   +2 more sources