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Complement Factor H related protein 1 and immune inflammatory disorders

Molecular Immunology, 2022
Human complement Factor H-related protein 1 (FHR-1) is one of complement Factor H-related proteins (FHRs) and plays an important role in innate immunity. In particular, FHR-1 promotes complement activation by competing with Factor H (FH) for ligands on different surfaces or directly binding to C3b and native C3.
Xiangru, Li, Jing, Zong, Shaoyan, Si
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Complement factor H related proteins in immune diseases

Vaccine, 2008
The complement system is a powerful part of the host innate immune defense and is aimed to damage and eliminate microbes and modified self-cells. To protect host cells and biological surfaces from damage mediated by complement activation products a tight control of the complement system is necessary.
Christine, Skerka, Peter F, Zipfel
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Factor H-Related Proteins

2013
Factor H-related proteins (CFHRs) are plasma glycoproteins related in structure and antigenicity to each other and to the complement inhibitory protein factor H. Such proteins are found in most mammals but their number and domain composition vary. This chapter summarizes our current knowledge on the human factor H-related proteins.
Józsi, Mihály, Meri, Seppo
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HUMAN COMPLEMENT FACTOR H RELATED PROTEIN TEST FOR MONITORING BLADDER CANCER

Journal of Urology, 2001
The BTA stat test is a rapid, noninvasive, qualitative urine test that detects bladder tumor associated antigen (human complement factor H related protein) in urine. We compared BTA stat test to voided urine cytology in patients monitored for bladder cancer in a prospective trial, and determined whether this test is effective in detection of recurrence
M P, Raitanen   +6 more
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Polymorphism and deficiency of human factor H-related proteins p39 and p37

Immunogenetics, 1992
We described previously cDNA clones representing a novel factor H-related 1.4 kilobase mRNA. This mRNA species codes for a doublet of serum proteins of M(r) 39,000 and 37,000 (p39/p37). The respective recombinant proteins of the three clones H-69, pFH1.4a, and pFH1.4b differ in the expression of the epitope recognized by the monoclonal antibody (mAb ...
Elisabeth Feifel   +7 more
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Ultrasensitive Electrochemiluminescence Immunosensor for Bladder Marker Human Complement Factor H-Related Protein Detection

Analytical Chemistry, 2023
The development of noninvasive and sensitive detection methods for the early diagnosis and monitoring of bladder cancer is critical but challenging. Herein, an ultrasensitive electrochemiluminescence (ECL) immunosensor that uses Ru(bpy)32+-metal-organic framework (Ru-MOF) nanospheres and a DNA tetrahedral (TDN) probe was established for bladder cancer ...
Jingjing Zhang   +7 more
openaire   +2 more sources

Factor H-related protein-5: A novel component of human glomerular immune deposits

American Journal of Kidney Diseases, 2002
Factor H-related protein-5 (FHR-5) is a newly described human plasma protein with structural similarities to human factor H and the four other recently described factor H-related proteins. Unlike the other factor H-related proteins, FHR-5 was initially identified at the protein, rather than complementary DNA, level in studies of glomerular immune ...
Brendan, Murphy   +4 more
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