Results 31 to 40 of about 12,986,553 (373)

Monitoring heparin therapy: stability of two different anti-Xa assays using blood samples collected in citrate-containing and CTAD tubes

Thrombosis Journal, 2023
Background Anti-factor Xa assays and activated partial thromboplastin time (aPTT) are mainly employed to monitor patients treated with heparins. According to the Clinical and Laboratory Standards Institute and the French Working Group on Haemostasis and ...
Marion Gremillet, Laurie Talon, Aurélien Lebreton, Thomas Sinegre   +3 more
doaj   +1 more source

Factor Xa Inhibitor-Related Intracranial Hemorrhage

Circulation, 2020
Supplemental Digital Content is available in the text. Background: Since the approval of the oral factor Xa inhibitors, there have been concerns regarding the ability to neutralize their anticoagulant effects after intracranial hemorrhage (ICH). Multiple
N. Panos, A. Cook, Sayona John, G. M. Jones, Hallie Kelly, Richard K. Choi, Nirali Kalaria, J. Rosini, Mathew C. Jones, Mohammed F. Rehman, P. M. Ross, Benjamin Motley, Samantha Delibert, B. George, C. Andrews, Ron R. Neyens, Ryan Martin, Kendra J Schomer, Michael J. Armahizer, Mehrnaz Pajoumand, Casey C. May, K. Smetana, T. Strohm, C. Hamm, L. Jakubowski, Shaun P. Keegan, Vasisht Srinivasan, Christopher J. Burdick, Omar J. Martinez, F. Bahrassa, Scott T. May, K. A. Sowers, E. Lin, Deidre Rohaley, J. Mackey, Lori L. Wetmore, C. Frick, Meena Thatikunta, Lindsay Urben, Abdalla A. Ammar, K. Owusu, K. Nguyen, Michael J. Erdman, B. Gilbert, Joshua M. DeMott, G. Peksa, Philip E. Tobias, Ivan Da Silva, Leana Mahmoud, Bethany A. Sheahan, A. Gennaro, Michael Pizzi, Gretchen M. Brophy, D. Rivet, Micheal Strein, Kristine Arandela, Van T. Hellerslia, Meghan M. Caylor   +57 more
semanticscholar   +1 more source

Comparison of an Oral Factor Xa Inhibitor With Low Molecular Weight Heparin in Patients With Cancer With Venous Thromboembolism: Results of a Randomized Trial (SELECT-D).

Journal of Clinical Oncology, 2018
Purpose Venous thromboembolism (VTE) is common in patients with cancer. Long-term daily subcutaneous low molecular weight heparin has been standard treatment for such patients.
A. Young, A. Marshall, Jenny Thirlwall, O. Chapman, A. Lokare, C. Hill, Danielle Hale, J. Dunn, G. Lyman, Charles E. Hutchinson, P. Maccallum, Ajay Kakkar, F. Hobbs, S. Petrou, J. Dale, C. Poole, A. Maraveyas, M. Levine   +17 more
semanticscholar   +1 more source

The spatial temporal regime of stream flow of the conterminous U.S. in connection with indices of global atmospheric circulation [PDF]

, 2007
Long-term stream flow records (1929-1988) from seventy one U.S. Geological Survey gauging stations with drainage area in range 1000-10000 sq mi were analyzed using multivariate statistics. Factor analysis of average annual flow revealed seven patterns of
Boris Shmagin, Carol A. Johnston, Scott Bridgham   +2 more
core   +2 more sources

Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells

Haematologica, 2014
Vitamin K-dependent proteases generated in response to vascular injury and infection enable fibrin clot formation, but also trigger distinct immuno-regulatory signaling pathways on myeloid cells.
Eimear M. Gleeson, James S. O’Donnell, Emily Hams, Fionnuala Ní Áinle, Bridget-Ann Kenny, Padraic G. Fallon, Roger J.S. Preston   +6 more
doaj   +1 more source

Establishment of prophylactic enoxaparin dosing recommendations to achieve targeted anti-factor Xa concentrations in children with CHD [PDF]

, 2018
Background Enoxaparin may be used to prevent central venous catheter-related thrombosis in patients with CHD. We aimed to determine whether current enoxaparin dosing regimens effectively achieve anti-factor Xa concentrations within prophylactic goal ...
Israel, Emily N., Mastropietro, Christopher W., Thomas, Christopher A.   +2 more
core   +1 more source

Gla-domainless factor Xa: molecular bait to bypass a blocked tenase complex

Haematologica, 2012
Background Hemophilia is caused by deficiencies in coagulation factor VIII or IX, resulting in direct blockade of the intrinsic tenase complex and indirect blockade of the extrinsic tenase complex which is rapidly inhibited upon binding of factor Xa to ...
Raphaël Marlu, Benoît Polack
doaj   +1 more source

Factor Xa and thrombin induce endothelial progenitor cell activation. The effect of direct oral anticoagulants

Platelets, 2021
Factor Xa (FXa) and thrombin exert non-hemostatic cellular actions primarily mediated through protease-activated receptors (PARs). We investigated the effect of FXa and thrombin on human late-outgrowth endothelial cells (OECs), a type of endothelial ...
Styliani Papadaki, Sofia Sidiropoulou, Iraklis C. Moschonas, Alexandros D. Tselepis   +3 more
doaj   +1 more source

Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors

New England Journal of Medicine, 2019
Background Andexanet alfa is a modified recombinant inactive form of human factor Xa developed for reversal of factor Xa inhibitors. Methods We evaluated 352 patients who had acute major bleeding within 18 hours after administration of a factor Xa ...
S. Connolly, M. Crowther, J. Eikelboom, M. Gibson, J. Curnutte, J. Lawrence, Patrick Yue, M. Bronson, Genmin Lu, P. Conley, P. Verhamme, Jeannot Schmidt, S. Middeldorp, A. Cohen, J. Beyer-Westendorf, P. Albaladéjo, J. López-Sendón, A. Demchuk, D. Pallin, M. Concha, S. Goodman, J. Leeds, Sonia Souza, D. Siegal, E. Zotova, Brandi Meeks, S. Ahmad, J. Nakamya, T. Milling   +28 more
semanticscholar   +1 more source

Assessing Anticoagulation in Neonates With Congenital Diaphragmatic Hernia During Extracorporeal Membrane Oxygenation: Does Anti-Factor Xa or Thromboelastometry Provide Additional Benefit?

Frontiers in Pediatrics, 2021
Objective: The optimal management of anticoagulation in neonatal/pediatric patients during extracorporeal membrane oxygenation (ECMO) has not been established yet and varies greatly among ECMO centers worldwide.
Alba Perez Ortiz, Carl E. Dempfle, Toni Jung, Thalia Doniga, Christel Weiß, Svetlana Hetjens, Thomas Schaible, Neysan Rafat   +7 more
doaj   +1 more source