Results 1 to 10 of about 22,623 (220)

Inhibiting Fatty Acid Amide Hydrolase Ameliorates Enteropathy in Diabetic Mice: A Cannabinoid 1 Receptor Mediated Mechanism [PDF]

Veterinary Sciences, 2022
Gastrointestinal (GI) dysmotility in diabetics exhibits fecal incontinence or constipation which affects patients’ quality of life. In this study, we aimed to understand the pattern of GI transit in type 1 diabetic (T1D) mice and whether inhibiting ...
Vikram Thakur, Mohammad Bashashati, Josue Enriquez, Munmun Chattopadhyay   +3 more
doaj   +2 more sources

Fatty acid amide hydrolase levels in brain linked with threat-related amygdala activation [PDF]

NeuroImage: Reports, 2022
Background: Preclinical evidence suggests that increasing levels of the major endocannabinoid anandamide decreases anxiety and fear responses potentially through its effects in the amygdala.
Duncan GJ. Green, Duncan J. Westwood, Jinhee Kim, Laura M. Best, Stephen J. Kish, Rachel F. Tyndale, Tina McCluskey, Nancy J. Lobaugh, Isabelle Boileau   +8 more
doaj   +2 more sources

Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer [PDF]

Nature Communications, 2023
Clinical management of breast cancer (BC) metastasis remains an unmet need as it accounts for 90% of BC-associated mortality. Although the luminal subtype, which represents >70% of BC cases, is generally associated with a favorable outcome, it is ...
Isabel Tundidor, Marta Seijo-Vila, Sandra Blasco-Benito, María Rubert-Hernández, Sandra Adámez, Clara Andradas, Sara Manzano, Isabel Álvarez-López, Cristina Sarasqueta, María Villa-Morales, Carmen González-Lois, Esther Ramírez-Medina, Belén Almoguera, Antonio J. Sánchez-López, Laura Bindila, Sigrid Hamann, Norbert Arnold, Christoph Röcken, Ignacio Heras-Murillo, David Sancho, Gema Moreno-Bueno, María M. Caffarel, Manuel Guzmán, Cristina Sánchez, Eduardo Pérez-Gómez   +24 more
doaj   +2 more sources

Identification of quinolinyl-containing dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors with moderate potency towards acetylcholinesterase [PDF]

Results in Chemistry
Using a polypharmacological approach, we designed two different quinolinyl libraries by merging the pharmacophores of three targeted enzymes, fatty acid amide hydrolase (FAAH), soluble epoxide hydrolase (sEH), and acetylcholinesterase (AChE).
Michael Gonzalez, Ryan West, Amanda Tsang, Olivia Ocampo, Paula K. Hudson, Stevan Pecic   +5 more
doaj   +2 more sources

Epigenetic regulation of fatty acid amide hydrolase in Alzheimer disease.

PLoS ONE, 2012
ObjectiveAlzheimer disease (AD) is a progressive, degenerative and irreversible neurological disorder with few therapies available. In search for new potential targets, increasing evidence suggests a role for the endocannabinoid system (ECS) in the ...
Claudio D'Addario, Andrea Di Francesco, Beatrice Arosio, Cristina Gussago, Bernardo Dell'Osso, Monica Bari, Daniela Galimberti, Elio Scarpini, A Carlo Altamura, Daniela Mari, Mauro Maccarrone   +10 more
doaj   +5 more sources

Fatty Acid Amide Hydrolase Signaling and Ovarian Disorders: From Molecular Mechanism to Clinical Significance [PDF]

Molecules
Fatty acid amide hydrolase (FAAH) is a central component of the endocannabinoid system (ECS), where it primarily regulates intracellular levels of anandamide (AEA) through enzymatic hydrolysis.
Qinghe Lin, Zhenghong Zhang, Defan Wang, Fan Wang, Zhengchao Wang   +4 more
doaj   +2 more sources

Fatty acid amide hydrolase is lower in young cannabis users. [PDF]

Addict Biol, 2021
AbstractWe have recently shown that levels of fatty acid amide hydrolase (FAAH), the enzyme that metabolizes the endocannabinoid anandamide, are lower in the brains of adult cannabis users (CUs) (34 ± 11 years of age), tested during early abstinence. Here, we examine replication of the lower FAAH levels in a separate, younger cohort (23 ± 5 years of ...
Jacobson MR, Watts JJ, Da Silva T, Tyndale RF, Rusjan PM, Houle S, Wilson AA, Ross RA, Boileau I, Mizrahi R.   +9 more
europepmc   +4 more sources

Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation [PDF]

Cell Death Discovery
Mammary gland development occurs primarily in adulthood, undergoing extensive expansion during puberty followed by cycles of functional specialization and regression with every round of pregnancy/lactation/involution. This process is ultimately driven by
Isabel Tundidor, Marta Seijo-Vila, Sandra Blasco-Benito, María Rubert-Hernández, Gema Moreno-Bueno, Laura Bindila, Rubén Fernández de la Rosa, Manuel Guzmán, Cristina Sánchez, Eduardo Pérez-Gómez   +9 more
doaj   +2 more sources

Quinolinyl-based multitarget-directed ligands with soluble epoxide hydrolase and fatty acid amide hydrolase inhibitory activities: Synthetic studies and pharmacological evaluations [PDF]

Heliyon
Simultaneous inhibition of soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH) with a single small molecule represents a novel therapeutic approach in treating inflammatory pain, since both targets are involved in pain and inflammation ...
Jeannes Angelia, Leah Duong, Faye Yun, Anesa Mesic, Cassandra Yuan, Daniel Carr, Siena Gunari, Paula K. Hudson, Christophe Morisseau, Bruce D. Hammock, Ram Kandasamy, Stevan Pecic   +11 more
doaj   +2 more sources

A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase. [PDF]

Science
Undernutrition in Bangladeshi children is associated with disruption of postnatal gut microbiota assembly; compared with standard therapy, a microbiota-directed complementary food (MDCF) substantially improved their ponderal and linear growth.
Cheng J, Venkatesh S, Ke K, Barratt MJ, Gordon JI.   +4 more
europepmc   +3 more sources