Results 101 to 110 of about 22,623 (220)

Targeting the Endocannabinoid Metabolic Enzymes to Reduce Inflammatory Pain [PDF]

, 2014
Pain is a debilitating condition that presents a problem of clinical relevance. Common analgesics include opioids and non-steroidal anti-inflammatory drugs (NSIADs).
Ghosh, Sudeshna
core   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Fatty acid modulation of the endocannabinoid system and the effect on food intake and metabolism [PDF]

, 2013
Endocannabinoids and their G-protein coupled receptors (GPCR) are a current research focus in the area of obesity due to the system’s role in food intake and glucose and lipid metabolism.
Hryciw, Deanne H, Mathai, Michael, McAinch, Andrew, Naughton, Shaan   +3 more
core   +3 more sources

Chemical Characterization of Postindustrial Recycled Polyethylene Terephthalate Obtained From Multilayer PET/PE Sheets: A Baseline Study on Safety Aspects

Packaging Technology and Science, Volume 39, Issue 3, Page 257-270, March 2026.
PET trays pose recycling challenges due to multilayer structures with polyethylene (PE) tie‐layers and barrier materials. In this study, a delamination process using a hot alkaline solution was applied to postindustrial multilayer PET/PE thermoforming waste to recover PET flakes and produce sheets.
Isabela F. A. Daras, Srishti Singh, Tiago Vieira, Joel Pereira, Patrícia Guerreiro, Clara Sousa, Fátima Poças   +6 more
wiley   +1 more source

Redox system and phospholipid metabolism in the kidney of hypertensive rats after FAAH inhibitor URB597 administration

Redox Biology, 2018
Primary and secondary hypertension is associated with kidney redox imbalance resulting in enhanced reactive oxygen species (ROS) and enzymes dependent phospholipid metabolism.
Michał Biernacki, Ewa Ambrożewicz, Agnieszka Gęgotek, Marek Toczek, Katarzyna Bielawska, Elżbieta Skrzydlewska   +5 more
doaj   +1 more source

Anxiofit‐1 and reduction of subthreshold and mild anxiety: Evaluation of a health claim pursuant to article 14 of regulation (EC) No 1924/2006

EFSA Journal, Volume 24, Issue 3, March 2026.
Abstract Following an application from Anxiofit Ltd. pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of Hungary, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked for an opinion on the scientific substantiation of a health claim related to Anxiofit‐1 and reduction of subthreshold and mild ...
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan de Henauw, Karen‐Ildico Hirsch‐Ernst, Angeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Frank Thies, Ines Drenjančević, Ionut Craciun, Alfonso Siani   +17 more
wiley   +1 more source

Modulation of the Endocannabinoid System as a Potential Anticancer Strategy

Frontiers in Pharmacology, 2019
Currently, the involvement of the endocannabinoid system in cancer development and possible options for a cancer-regressive effect of cannabinoids are controversially discussed.
Robert Ramer, Rico Schwarz, Burkhard Hinz   +2 more
doaj   +1 more source

Unraveling Endocannabinoid Signaling Pathways in Cisplatin‐Induced Ototoxicity

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
We performed a comprehensive molecular profiling of the endocannabinoid (eCB) system (ECS) in an auditory Hair cell (HC)‐like cell line (1). Afterwards, we developed suitable in vitro and in vivo models of cisplatin‐induced ototoxicity where we identified distinct components of the ECS (CB2R, DAGLβ and ABHD6) as molecular targets of the drug (2 ...
Sakthimala Palaniappan, Annamaria Tisi, Camilla Di Meo, Cristina Urbano, Georgina E. Fenton, Francesco Della Valle, Federico Fanti, Dario Compagnone, Marc Nazarè, Huib Versnel, Andrea Aramini, Marcello Allegretti, Mauro Maccarrone   +12 more
wiley   +1 more source

Characterization of biotin-anandamide, a novel tool for the visualization of anandamide accumulation

Journal of Lipid Research, 2008
Anandamide (N-arachidonoylethanolamide; AEA) acts as an endogenous agonist of both cannabinoid and vanilloid receptors. During the last two decades, its metabolic pathways and biological activity have been investigated extensively and relatively well ...
Filomena Fezza, Sergio Oddi, Monia Di Tommaso, Chiara De Simone, Cinzia Rapino, Nicoletta Pasquariello, Enrico Dainese, Alessandro Finazzi-Agrò, Mauro Maccarrone   +8 more
doaj   +1 more source

α-Ketoheterocycle-Based Inhibitors of Fatty Acid Amide Hydrolase (FAAH)

ACS Chemical Neuroscience, 2012
A summary of the initial discovery and characterization of the enzyme fatty acid amide hydrolase (FAAH), and the subsequent advancement of an important class of competitive, reversible, potent and selective inhibitors is presented. Initially explored using substrate-inspired inhibitors bearing electrophilic carbonyls, the examination of α ...
Katerina, Otrubova, Dale L, Boger
openaire   +3 more sources