Results 31 to 40 of about 22,623 (220)

Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation [PDF]

, 2011
The herb Cannabis sativa (C. sativa) has been used in China and on the Indian subcontinent for thousands of years as a medicine. However, since it was brought to the UK and then the rest of the western world in the late 19th century, its use has been a ...
Adams, Agrawal, Ahern, Alger, Armstrong, Arnone, Avraham, Bachur, Baker, Baker, Barbano, Basavarajappa, Basavarajappa, Ben Amar, Ben-Zvi, Berridge, Berridge, Bisogno, Blankman, Bortolato, Breivogel, Brown, Brown, Burkey, Cadas, Cahn, Chan, Childers, Clark, Comelli, Consroe, Costiniuk, Cota, Cota, Cota, Cravatt, Davis, Davis, De Filippis, De Petrocellis, De Petrocellis, Deadwyler, Dennis, Deutsch, Devane, Devane, Dewey, Di Marzo, Di Marzo, Di Marzo, Di Marzo, Di Marzo, Elmquist, Engeli, Evans, Fadda, Farrimond, Farrimond, Felder, Fong, Fonseca, Fredriksson, Freund, Gaetani, Gallate, Gaoni, Gaoni, Gaoni, Gardner, Gatley, Gerdeman, Gill, Glass, Glick, Gomez, Gong, Goutopoulos, Grant, Hao, Henstridge, Henstridge, Herkenham, Herkenham, Higgs, Hohmann, Holland, Hollister, Horswill, Hosohata, Howlett, Howlett, Howlett, Huffman, Hughes, Ishiguro, Izzo, Jamshidi, Jarrett, Jarrett, Jin, Kapur, King, Kirby, Kirkham, Kirkham, Kirkham, Kirkham, Kirkham, Koch, Lambert, Landsman, Lauckner, Lauckner, Ligresti, Little, Liu, Long, Ma, Maccarrone, Maccarrone, Mackie, Mackie, Makriyannis, Martin, Mathes, Matsuda, Mechoulam, Mechoulam, Moldrich, Morgan, Morley, Munro, Naidu, Ning, Ohno-Shosaku, Okamoto, Okamoto, Okamoto, Onaivi, Onaivi, Onaivi, Osei-Hyiaman, Overton, Overton, Oz, Pacheco, Pertwee, Pertwee, Pertwee, Pertwee, Pertwee, Pertwee, Pertwee, Pertwee, Petitet, Petrosino, Pietr, Piomelli, Piomelli, Piomelli, Pope, Pryce, Pryce, Putney, Rao, Riedel, Rinaldi-Carmona, Rinaldi-Carmona, Rodriguez de Fonseca, Ronesi, Ross, Ross, Ryan, Ryberg, Sanger, Sawzdargo, Schweitzer, Showalter, Simiand, Sink, Sofia, Soga, Solinas, Staton, Stratford, Sugiura, Sugiura, Sugiura, Südhof, Takeda, Thomas, Thornton-Jones, Tramer, Tsou, Turu, Van Gaal, Van Sickle, Vandevoorde, Walsh, Wang, Werner, Whalley, Wiley, Wilkinson, Williams, Williams, Williams, Williams, Williamson, Wilson, Woolridge, Yamauchi, Yan, Yates, Yoshida, Zhu   +215 more
core   +3 more sources

Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study.

PLoS ONE, 2014
BackgroundThe endocannabinoid ligand anandamide (AEA) is removed from the extracellular space by a process of cellular uptake followed by metabolism. In many cells, such as the RBL-2H3 cell line, inhibition of FAAH activity reduces the observed uptake ...
Emmelie Björklund, Anders Blomqvist, Joel Hedlin, Emma Persson, Christopher J Fowler   +4 more
doaj   +1 more source

Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women [PDF]

, 2010
N-acylethanolamines (NAEs), such as anandamide (AEA), are a group of endogenous lipids derived from a fatty acid linked to ethanolamine and have a wide range of biological activities, including regulation of metabolism and food intake.
Balvers, M.G.J., Hendriks, H.F.J., Joosten, M.M., Verhoeckx, K.C.M., Witkamp, R.F.   +4 more
core   +2 more sources

Discovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase

Molecules, 2016
Fatty Acid Amide Hydrolase (FAAH) is an intracellular serine enzyme involved in the biological degradation of the fatty acid ethanolamide family of signaling lipids, which exerts neuroprotective, anti-inflammatory, and analgesic properties.
Yan Qiu, Yang Zhang, Yuhang Li, Jie Ren
doaj   +1 more source

Plasma Biomarkers for Monitoring Brain Pathophysiology in FMR1 Premutation Carriers. [PDF]

, 2016
Premutation carriers have a 55-200 CGG expansion in the fragile X mental retardation 1 (FMR1) gene. Currently, 1.5 million individuals are affected in the United States, and carriers are at risk of developing the late-onset neurodegenerative disorder ...
Giulivi, Cecilia, Hagerman, Randi, Halmai, Julian, Napoli, Eleonora, Tassone, Flora   +4 more
core   +2 more sources

Overexpression of fatty acid amide hydrolase induces early flowering in Arabidopsis thaliana

Frontiers in Plant Science, 2012
N-Acylethanolamines (NAEs) are bioactive lipids derived from the hydrolysis of the membrane phospholipid N-acylphosphatidylethanolamine (NAPE). In animal systems this reaction is part of the endocannabinoid signaling pathway, which regulates a variety of
Neal D. Teaster, Jantana eKeereetaweep, Aruna eKilaru, Yuh-Shuh eWang, Yuhong eTang, Christopher N-Q Tran, Brian G. Ayre, Kent D. Chapman, Elison B. Blancaflor   +8 more
doaj   +1 more source

Anti-Inflammatory Effects of Fatty Acid Amide Hydrolase Inhibition in Monocytes/Macrophages from Alzheimer’s Disease Patients

Biomolecules, 2021
Growing evidence shows that the immune system is critically involved in Alzheimer’s disease (AD) pathogenesis and progression. The modulation and targeting of peripheral immune mechanisms are thus promising therapeutic or preventive strategies for AD ...
Valerio Chiurchiù, Lucia Scipioni, Beatrice Arosio, Daniela Mari, Sergio Oddi, Mauro Maccarrone   +5 more
doaj   +1 more source

Inhibitory properties of ibuprofen and its amide analogues towards the hydrolysis and cyclooxygenation of the endocannabinoid anandamide [PDF]

, 2013
A dual-action cyclooxygenase (COX)–fatty acid amide hydrolase (FAAH) inhibitor may have therapeutic usefulness as an analgesic, but a key issue is finding the right balance of inhibitory effects.
Björklund E, CONGIU, CENZO, Fowler CJ, Lichtman AH, Naidu PS, ONNIS, VALENTINA   +5 more
core   +1 more source

Predicting the bioactive compounds of Lentinula edodes and elucidating its interaction with genes associated to obesity through network pharmacology and in-vitro cell-based assay

Heliyon
Mushrooms are traditionally used for various medicinal purposes in traditional oriental medicine. The Japanese and Chinese are familiar with the medicinal macro fungus Lentinula edodes (Shiitake mushroom). This study aims to evaluate the role of chemical
Jasmeet Kaur, Humaira Farooqi, Kailash Chandra, Bibhu Prasad Panda   +3 more
doaj   +1 more source

Release of anandamide from blood cells [PDF]

, 2006
Background: Endogenous ligands of cannabinoid receptors ( endocannabinoids), in particular anandamide ( arachidonylethanolamide), have been recognized as being of crucial importance in a variety of physiological functions.
Bisogno, Chiang, Cravatt, Cravatt, De Marchi, Despres, Devane, Di, Di Marzo, Di Marzo, Fernandez, Freund, Giuffrida, Giuffrida, Habayeb, Klein, Klein, Maccarrone, Matsuda, Munro, Obata, Parolaro, Pertwee, Randall, Sipe, Sparling, Sugiura, Wagner, Wagner, Walker, Yamaji   +30 more
core   +1 more source