Results 41 to 50 of about 22,623 (220)

Subcellular localization and tissue specific expression of amidase 1 from Arabidopsis thaliana [PDF]

, 2006
Amidase 1 (AMI1) from Arabidopsis thaliana converts indole-3-acetamide (IAM), into indole-3-acetic acid (IAA). AMI1 is part of a small isogene family comprising seven members in A.
A Müller, A Müller, A Vojta, A Wachter, AM Metz, AW Woodward, BA Stelmach, BF Cravatt, Daniel Neu, DE Saslowsky, DK Giang, E Kemper, Elmar W. Weiler, EW Weiler, FA Ausubel, H Towbin, J Haseloff, J Sambrook, J-F Mayaux, JJ Finer, K Sohrt, KD Scharf, M Kawaguchi, M Kawaguchi, M Kobayashi, M Madera, M Saotome, MH Bracey, MM Bradford, MP Patricelli, NM Upadhyaya, NR Hofmann, O Chew, O Kleiner, Oliver Berkowitz, R Shrestha, R Shrestha, S Brenner, S Pollmann, S Pollmann, S Shin, S Shin, S Vorwerk, SR Cutler, Stephan Pollmann, T Murashige, Thomas Lehmann, Tina Schäfer, VS Reddy, WB Bruce, Y Arai, YJ Lee, YQ An, YS Kim   +53 more
core   +2 more sources

Fatty acid amide hydrolase deficiency limits early pregnancy events [PDF]

Journal of Clinical Investigation, 2006
Synchronized preimplantation embryo development and passage through the oviduct into the uterus are prerequisites for implantation, dysregulation of which often leads to pregnancy failure in women. Cannabinoid/endocannabinoid signaling via cannabinoid receptor CB1 is known to influence early pregnancy.
Haibin, Wang, Huirong, Xie, Yong, Guo, Hao, Zhang, Toshifumi, Takahashi, Philip J, Kingsley, Lawrence J, Marnett, Sanjoy K, Das, Benjamin F, Cravatt, Sudhansu K, Dey   +9 more
openaire   +2 more sources

Role of cannabinoids in gastrointestinal mucosal defense and inflammation. [PDF]

, 2016
Modulating the activity of the endocannabinoid system influences various gastrointestinal physiological and pathophysiological processes, and cannabinoid receptors as well as regulatory enzymes responsible for the synthesis or degradation of ...
Gyires Klára, Zádori Zoltán Sándor
core   +2 more sources

Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study[S]

Journal of Lipid Research, 2011
Chronic alcohol consumption is associated with fatty liver disease in mammals. The object of this study was to gain an understanding of dysregulated lipid metabolism in alcohol-fed C57BL/6 mice using a targeted lipidomic approach.
Robin D. Clugston, Hongfeng Jiang, Man Xia Lee, Roseann Piantedosi, Jason J. Yuen, Rajasekhar Ramakrishnan, Michael J. Lewis, Max E. Gottesman, Li-Shin Huang, Ira J. Goldberg, Paul D. Berk, William S. Blaner   +11 more
doaj   +1 more source

Tetracosahexaenoylethanolamide, a novel N-acylethanolamide, is elevated in ischemia and increases neuronal output

Journal of Lipid Research, 2020
N-acylethanolamines (NAEs) are endogenous lipid-signaling molecules derived from fatty acids that regulate numerous biological functions, including in the brain.
Lin Lin, Adam H. Metherel, Mathieu Di Miceli, Zhen Liu, Cigdem Sahin, Xavier Fioramonti, Carolyn L. Cummins, Sophie Layé, Richard P. Bazinet   +8 more
doaj   +1 more source

Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. [PDF]

, 2007
Recent studies have uncovered important cross talk between inflammation, generation of reactive oxygen and nitrogen species, and lipid metabolism in the pathogenesis of cardiovascular aging.
Bátkai, S., Cravatt, B.F., Csiszár, A., Haskó, G., Liaudet, L., Mukhopadhyay, P., Pacher, P., Rajesh, M., Ungvári, Z.   +8 more
core   +1 more source

The Endocannabinoid System, Aggression, and the Violence of Synthetic Cannabinoid Use, Borderline Personality Disorder, Antisocial Personality Disorder, and Other Psychiatric Disorders

Frontiers in Behavioral Neuroscience, 2018
Endogenous and exogenous cannabinoids bind to central cannabinoid receptors to control a multitude of behavioral functions, including aggression. The first main objective of this review is to dissect components of the endocannabinoid system, including ...
Nathan J. Kolla, Nathan J. Kolla, Nathan J. Kolla, Achal Mishra, Achal Mishra   +4 more
doaj   +1 more source

Polypharmacological Approaches for CNS Diseases: Focus on Endocannabinoid Degradation Inhibition

Cells, 2022
Polypharmacology breaks up the classical paradigm of “one-drug, one target, one disease” electing multitarget compounds as potential therapeutic tools suitable for the treatment of complex diseases, such as metabolic syndrome, psychiatric or degenerative
Alessandro Papa, Silvia Pasquini, Chiara Contri, Sandra Gemma, Giuseppe Campiani, Stefania Butini, Katia Varani, Fabrizio Vincenzi   +7 more
doaj   +1 more source

From Fertilisation to Implantation in Mammalian Pregnancy-Modulation of Early Human Reproduction by the Endocannabinoid System. [PDF]

, 2010
There is an increasing recognition that the endocannabinoid system is the crucial cytokine-hormone system regulating early human pregnancy. The synchronous development of the fertilized embryo and the endometrium to ensure timely implantation has been ...
Abel, Alger, Alpha Gebeh, Anthony H. Taylor, Aquila, Aquila, Aquila, Arnone, Barrett, Battista, Battista, Bisogno, Blankman, Bray, Bray, Carreau, Chabbert Buffet, Chmurzynska, Cobellis, Devane, Devane, Di Marzo, Di Marzo, Di Marzo, Dinh, El-Talatini, El-Talatini, Evers, Fonseca, Francavilla, Furuhashi, Geber, Gervasi, Godlewski, Gong, Grimaldi, Guo, Guzeloglu-Kayisli, Habayeb, Habayeb, Habayeb, Habayeb, Helliwell, Horne, Idris, Jonathon M. Willets, Justin C. Konje, Kaczocha, Katerina N. Bambang, Kim, Lambert, Larqué, Leung, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maingret, Matsuda, Mechoulam, Mechoulam, Meizel, Muccioli, Munro, Newton, Nixon, O'Sullivan, Okamoto, Pan, Pandey, Paria, Paria, Paria, Paria, Paria, Park, Patricia Lam, Pestonjamasp, Piccini, Pierantoni, Ravinet Trillou, Regan, Rodriguez de Fonseca, Rodriguez de Fonseca, Ross, Rossato, Rossi, Schmid, Schuel, Schuel, Schuel, Schuel, Simiand, Sipe, Smith, Sofikitis, Sriraman, Sun, Tapia, Taylor, Taylor, Timothy H. Marczylo, Toth, Trabucco, Tsuboi, Tulay Karasu, Turco, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wei, Wenger, Wenger, Yamano, Yang   +125 more
core   +2 more sources

Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor.

PLoS ONE, 2015
BackgroundIncreased endocannabinoid tonus by dual-action fatty acid amide hydrolase (FAAH) and substrate selective cyclooxygenase (COX-2) inhibitors is a promising approach for pain-relief. One such compound with this profile is 2-(2-fluorobiphenyl-4-yl)-
Sandra Gouveia-Figueira, Jessica Karlsson, Alessandro Deplano, Sanaz Hashemian, Mona Svensson, Marcus Fredriksson Sundbom, Cenzo Congiu, Valentina Onnis, Christopher J Fowler   +8 more
doaj   +1 more source