Results 81 to 90 of about 22,623 (220)

Soluble Epoxide Hydrolase Inhibitors Improve Cornea Alkali Wound Healing

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Soluble epoxide hydrolase (sEH) inhibition enhances corneal wound healing following alkali injury. (A) Schematic representation of corneal injury induced by NaOH or ammonia showing elevated sEH expression in corneal keratocytes. This leads to rapid hydrolysis of epoxy fatty acids (EpFAs), reducing their bioavailability and contributing to enhanced ...
Xiaowen Lu, Christophe Morisseau, Khushi Jain, Zhong Chen, Amy J. Estes, Darryl Zeldin, Artiom Gruzdev, Aniqa Ahmed, Haley Cook, Bruce D. Hammock, Mitchell A. Watsky   +10 more
wiley   +1 more source

Enhanced Anandamide Plasma Levels in Patients with Complex Regional Pain Syndrome following Traumatic Injury: A Preliminary Report [PDF]

, 2009
The complex regional pain syndrome (CRPS) is a disabling neuropathic pain condition that may develop following injuries of the extremities. The pathogenesis of this syndrome is not clear; however, it includes complex interactions between the nervous and ...
Campolongo, P., Chouker, A., Hauer, D., Huge, V., Kaufmann, I., Schelling, G., Thiel, M., Vogeser, M.   +7 more
core   +1 more source

Polyurethane Cascade Depolymerization by a Combination of Thermal Pretreatment and Enzymatic Hydrolysis

ChemSusChem, Volume 19, Issue 5, 13 March 2026.
This study explored the cascade depolymerization of a polyether‐polyester polyurethane based on a combination of low‐temperature thermal treatment and enzymatic hydrolysis. Heat pretreatment changed the physicochemical properties of polyurethane, followed by cutinase‐catalyzed hydrolysis, leading to an increase in weight loss and the production of two ...
Shengwei Sun, Sathiyaraj Subramaniyan, Ganapathy Ranjani, Leandro Cid Gomes, Diana Bernin, Thomas Bayer, Uwe T. Bornscheuer, Minna Hakkarainen, Per‐Olof Syrén   +8 more
wiley   +1 more source

Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans [PDF]

, 2013
Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive ...
A Bechara, A Busquets-Garcia, A Egerton, A Egerton, A Kofalvi, A Luchicchi, AB Fagundo, Amparo del Pino-Gutierrez, Ana B. Fagundo, Antoni Pastor, CD Verrico, CH Ashton, Cristina Botella, CT Whitlow, D Leung, D Robbe, DA Eldreth, DK Nomura, E Schlicker, EK Miller, Felipe F. Casanueva, Fernando Fernández-Aranda, Francisco J. Tinahones, G Marsicano, Gema Frühbeck, GL Gerdeman, HG Pope, Inés Moragrega, J Koppel, J McDonald, Javier Gómez-Ambrosi, JG Ramaekers, JJ Burston, Jose C. Fernández-García, Jose M. Fernández-Real, José M. Menchón, K Starowicz, K Tchanturia, KI Bolla, KI Bolla, L Lacroix, L Sokolic, LA Matsuda, M Beltramo, M Diana, M Egertova, M Egertova, M Herkenham, M Klugmann, M Maccarrone, M Pistis, MN Hill, MN Hill, MR Pazos, MR Stefani, MR Stefani, N Hajos, N Solowij, ND Volkow, P Lafenetre, P Monteleone, R Depoortere, Rafael de la Torre, RD Crean, RI Wilson, RJ Mathew, RJ Mathew, RK Stoving, RN Takahashi, Rosa Baños, Roser Granero, Roser Rodríguez, S Gaetani, S Mato, S Petrosino, SA Gruber, SA Varvel, SA Varvel, Salomé Tárrega, SD Lane, SJ Borgwardt, Susana Jiménez-Murcia, T Bisogno, T Lundqvist, T Ohno-Shosaku, T Pattij, T Rubino, T Rubino, T Sugiura, TJ De Vries, UN Danner, V Di Marzo, V Di Marzo, V Di Marzo, V Di Marzo, V Di Marzo, Vinod K. Yaragudri, WA Devane, Zaida Agüera   +98 more
core   +7 more sources

Exploring the Therapeutic Potential of Cannabidiol in Cutaneous Squamous Cell Carcinoma: An Integrated Computational and Experimental Study

International Journal of Quantum Chemistry, Volume 126, Issue 5, March 5, 2026.
Cannabidiol (CBD) exhibits increased reactivity, stronger CB1 receptor binding, and enhanced cytotoxicity against A431 squamous carcinoma cells compared to 5‐fluorouracil (5‐FU). Integrated DFT, molecular docking, and experimental analyses demonstrate CBD's improved stability and binding affinity, highlighting its potential as an alternative ...
Andrea Jess Josiah, Krishna Kuben Govender, Penny Poomani Govender, Werner Cordier, Margo Nell, Suprakas Sinha Ray   +5 more
wiley   +1 more source

A case series of the dynamics of lipid mediators in patients with sepsis

Acute Medicine & Surgery, 2019
Background Bioactive lipid mediators play a crucial role during infection. Previously, we showed the expression level of FAAH mRNA in septic patients was lower than in healthy controls.
Mitsuhide Hamaguchi, Heng Ning Wu, Masahiro Tanaka, Noriko Tsuda, Ourlad Alzeus Gaddi Tantengco, Tomohide Matsushima, Takami Nakao, Takuya Ishibe, Ikuhiro Sakata, Itaru Yanagihara   +9 more
doaj   +1 more source

Early blockade of joint inflammation with a fatty acid amide hydrolase inhibitor decreases end-stage osteoarthritis pain and peripheral neuropathy in mice

Arthritis Research & Therapy, 2017
Background The endocannabinoid system has been shown to reduce inflammatory flares and pain in rodent models of arthritis. A limitation of endocannabinoids is that they are rapidly denatured by hydrolysing enzymes such as fatty acid amide hydrolase (FAAH)
Jason J. McDougall, Milind M. Muley, Holly T. Philpott, Allison Reid, Eugene Krustev   +4 more
doaj   +1 more source

Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster

Cell Reports, 2020
Summary: Endocannabinoids protect against seizures, but their mechanism of action is still unclear, as they can have effects independent of known cannabinoid receptors. Using Drosophila melanogaster, which lacks canonical cannabinoid receptors, we report
Jack A. Jacobs, Amita Sehgal
doaj   +1 more source

Asymmetric Negishi and Kumada Couplings

Advanced Synthesis &Catalysis, Volume 368, Issue 5, 3 March 2026.
This review summarizes asymmetric Negishi and Kumada cross‐coupling reactions from the 1980s through 2025. It examines enantioselective and enantiospecific transformations catalyzed by nickel, palladium, and cobalt complexes , highlighting ligand design, mechanistic insights, and applications in constructing complex chiral molecules and natural ...
Rui‐Heng Wang, Aishun Ding, Ramon Rios
wiley   +1 more source

Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice

Neurobiology of Disease, 2015
Endocannabinoids, including 2-arachidonoylglycerol (2-AG), activate presynaptic cannabinoid type 1 receptors (CB1R) on inhibitory and excitatory neurons, resulting in a decreased release of neurotransmitters.
E.L. von Rüden, R.M. Bogdanovic, C.T. Wotjak, H. Potschka   +3 more
doaj   +1 more source