Results 111 to 120 of about 2,751,456 (226)

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Scd-1 deficiency promotes the differentiation of CD8+ T effector

Frontiers in Cellular and Infection Microbiology
The impact of various fatty acid types on adaptive immunity remains uncertain, and their roles remain unelucidated. Stearoyl-CoA desaturase (Scd) is a Δ-9 desaturase, which is a key rate-limiting enzyme for the conversion of saturated fatty acids (SFA ...
Yiwei Lin, Xushuo Li, Haojie Shan, Jie Gao, Yanying Yang, Linlan Jiang, Lu Sun, Yuwen Chen, Fangming Liu, Fangming Liu, Xiaowei Yu   +10 more
doaj   +1 more source

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

Immunology, EarlyView.
Natural Killer (NK) cells are potent effectors against virus‐infected and tumour cells. During Friend Virus (FV) infection, fatty acid metabolism supports NK‐cell effector functions. Here, we found that NK cells from FV‐infected mice preferentially take up linoleic acid (LA), which reduced proliferation, mitochondrial function, and increased reactive ...
Vaasudevan Sridhar, Simone Schimmer, Tanja Werner, Rachel Giesen, Mohamed Saad, Constantin P. Krempe, Sven W. Meckelmann, Ulf Dittmer, Elisabeth Littwitz‐Salomon   +8 more
wiley   +1 more source

Modulation of sebocyte function in acne: A pathway‐inclusive review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Acne is multifactorial, with the sebocyte acting as a central immunometabolic hub linking lipogenic, inflammatory, hormonal and barrier pathways. Mapping established and investigational therapies onto this sebocyte‐centred model offers a mechanism‐based framework that complements existing treatment paradigms and may guide more targeted, antibiotic ...
Christos C. Zouboulis, Apostolos Pappas, Katja Martin, Mauro Picardo   +3 more
wiley   +1 more source

Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source

Live yeast as a possible modulator of polyunsaturated fatty acid biohydrogenation in the rumen [PDF]

, 2010
In dairy cows, several studies focused on the effects of sodium bicarbonate and fibre on ruminal linoleic acid (c9c12-C18:2) biohydrogenation (BH) whereas literature is scarce about the effect of live yeast, used as a feed additive. The objective of this
Troegeler-Meynadier, Annabelle, Marden, Jean-Philippe, Bayourthe, Corine, Enjalbert, Francis, Julien, Christine   +4 more
core  

Fine‐tuning fatty acid composition enhances rice resistance to bacterial blight

Journal of Integrative Plant Biology, EarlyView.
Genome editing to insert an inhibitory element into the 5' untranslated region of the stearoyl‐acyl carrier protein desaturase gene OsSSI2 fine‐tuned fatty acid composition, creating mutants with enhanced bacterial blight resistance while maintaining normal growth and yield.
Rundong Shen, Xinbo Li, Yaqi Zhang, Liying Ding, Yongzhen Pang, Kexuan Tang   +5 more
wiley   +1 more source

Chimeras of delta6-fatty acid and delta8-sphingolipid desaturases

, 2000
The Borago officinalis Delta6 fatty acid desaturase (Boofd6) shares 58% identity in its amino acid sequence with Boofd8, a Delta8 sphingolipid desaturase from the same plant species.
Michaelson, L. V., Lewis, M. J., Libisch, B., Napier, J. A., Shewry, P. R.   +4 more
core   +1 more source

Similarities Between the Lipid Profiles of Skin and Liver of European Sea Bass (Dicentrarchus labrax) Fed Diets With Different Lipid Content

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT The fatty acid composition of fish is influenced by species, age, diet, and tissues, which respond differently to dietary lipids. This study examined how two commercial diets with contrasting polyunsaturated fatty acid (PUFA) profiles, affecting eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), alter the fatty acid composition in ...
Daniel González‐Silvera, Cristóbal Espinosa‐Ruiz, M. Ángeles Esteban   +2 more
wiley   +1 more source

Gene transfer of Chlorella vulgaris n-3 fatty acid desaturase optimizes the fatty acid composition of human breast cancer cells

Brazilian Journal of Medical and Biological Research, 2012
Chlorella vulgaris has the gene of n-3 fatty acid desaturase (CvFad3), which can synthesize the precursor of n-3 polyunsaturated fatty acids (PUFAs) or convert n-6 to n-3 PUFAs.
Meilan Xue, Yinlin Ge, Jinyu Zhang, Qing Wang, Lin Hou   +4 more
doaj   +2 more sources