Results 1 to 10 of about 13,450 (208)

Serum Nonesterified Fatty Acids and Incident Stroke: The CHS [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Significant associations between total nonesterified fatty acid (NEFA) concentrations and incident stroke have been reported in some prospective cohort studies.
Neil K. Huang, Mary L. Biggs, Nirupa R. Matthan, Luc Djoussé, W. T. Longstreth, Kenneth J. Mukamal, David S. Siscovick, Alice H. Lichtenstein   +7 more
doaj   +4 more sources

Effects of obesity-associated plasma markers on adipose stem cell function and epigenetic regulation. [PDF]

Obesity (Silver Spring)
Abstract Objective This study investigates the correlations between obesity‐related plasma markers and epigenetic/inflammatory changes in white adipose tissue (WAT), focusing on adipose‐derived stem cells (ASCs). We hypothesize that obesity modulates histone H3K27 marks, modified by demethylases (lysine‐specific demethylase 6A and 6B [KDM6A/KDM6B]) and
Bispo AFS, de Jesus Simao J, Moraes MA, Abel ABM, Plata VTG, Telles MM, Santana AV, Volpe P, Armelin-Correa LM, Alonso-Vale MIC.   +9 more
europepmc   +2 more sources

Association between plasma nonesterified fatty acids species and adipose tissue fatty acid composition. [PDF]

PLoS ONE, 2013
Fatty acid composition of adipose tissue (AT) is an established long-term biomarker for fatty acid (FA) intake and status, but AT samples are not easily available.
Christian Hellmuth, Hans Demmelmair, Isabel Schmitt, Wolfgang Peissner, Matthias Blüher, Berthold Koletzko   +5 more
doaj   +6 more sources

Fatty Acids and Inflammatory Protein Biomarkers From Coronavirus Disease 2019 Patients. [PDF]

Immun Inflamm Dis
The coronavirus disease 2019 (COVID‐19) pandemic created the need to identify new biomarkers and drug targets. In this study, we aimed to establish a unique signature profile of specific fatty acids, cytokines, and chemokines present in the plasma after COVID‐19 viral infection to serve as novel biomarkers that can be used to determine the severity of ...
Bala N, Habib AH, Kozuch M, Denslow ND, Dhaliwal NS, Owings AH, Glover SC, Alli AA.   +7 more
europepmc   +2 more sources

Subclinical Pregnancy Toxemia Affects Blood Parameters of Ewes and Impairs Postnatal Growth and Development of Lambs. [PDF]

Vet Med Sci
Subclinical pregnancy toxemia (SPT) negatively affects postnatal growth and development of lambs. ABSTRACT Pregnancy toxemia (PT) is a common metabolic disorder that occurs in the last trimester of pregnancy. This study aimed to detect the effects of subclinical PT (SPT) on serum biochemical parameters of ewes and postnatal growth and development of ...
Turgut AO, Küçük M, Irmak M, Özcan C, Koca D, Gülendağ E, Önen MF, Doğan R, Ünver A, Keskin İH.   +9 more
europepmc   +2 more sources

Very long-chain fatty acids are accumulated in triacylglycerol and nonesterified forms in colorectal cancer tissues

Scientific Reports, 2021
Colorectal cancer (CRC) is a major cancer, and its precise diagnosis is especially important for the development of effective therapeutics. In a series of metabolome analyses, the levels of very long chain fatty acids (VLCFA) were shown to be elevated in
Kotaro Hama, Yuko Fujiwara, Tamuro Hayama, Tsuyoshi Ozawa, Keijiro Nozawa, Keiji Matsuda, Yojiro Hashiguchi, Kazuaki Yokoyama   +7 more
doaj   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Substrate modulation of fatty acid effects on energization and respiration of kidney proximal tubules during hypoxia/reoxygenation. [PDF]

PLoS ONE, 2014
Kidney proximal tubules subjected to hypoxia/reoxygenation develop a nonesterified fatty acid-induced energetic deficit characterized by persistent partial mitochondrial deenergization that can be prevented and reversed by citric acid cycle substrates ...
Anja Bienholz, Ahmad Al-Taweel, Nancy F Roeser, Andreas Kribben, Thorsten Feldkamp, Joel M Weinberg   +5 more
doaj   +1 more source

Regulation of Insulin Clearance by Non-Esterified Fatty Acids

Biomedicines, 2022
Insulin stores lipid in adipocytes and prevents lipolysis and the release of non-esterified fatty acids (NEFA). Excessive release of NEFA during sustained energy supply and increase in abdominal adiposity trigger systemic insulin resistance, including in
Sonia M. Najjar, Raziyeh Abdolahipour, Hilda E. Ghadieh, Marziyeh Salehi Jahromi, John A. Najjar, Basil A. M. Abuamreh, Sobia Zaidi, Sivarajan Kumarasamy, Harrison T. Muturi   +8 more
doaj   +1 more source

The Role of TCA Cycle Anaplerosis in Ketosis and Fatty Liver in Periparturient Dairy Cows

Animals, 2015
The transition to lactation period in dairy cattle is characterized by metabolic challenges, negative energy balance, and adipose tissue mobilization. Metabolism of mobilized adipose tissue is part of the adaptive response to negative energy balance in ...
Heather M. White
doaj   +1 more source