Results 41 to 50 of about 5,164 (112)

Lipid exposure leads to metabolic dysfunction in fetal sheep cardiomyocytes

Physiological Reports, Volume 13, Issue 10, May 2025.
Abstract Fetal circulating lipids are low but rise precipitously following birth. It is unknown how prematurely elevated lipids affect the fetal heart, which primarily uses carbohydrates for energy. Fetal sheep were surgically instrumented and received Intralipid 20® or Lactated Ringer's Solution intravenously.
Natasha N. Chattergoon, Karthikeyan Bose, Samantha Louey, Sonnet S. Jonker   +3 more
wiley   +1 more source

Fatty liver in familial hypobetalipoproteinemia: Triglyceride assembly into VLDL particles is affected by the extent of hepatic steatosis [PDF]

, 2003
Familial hypobetalipoproteinemia (FHBL) subjects may develop fatty liver. Liver fat was assessed in 21 FHBL with six different apolipoprotein B (apoB) truncations (apoB-4 to apoB-89) and 14 controls by magnetic resonance spectroscopy (MRS).
Ackerman, J., AVERNA, Maurizio, Elias, N., Patterson, B., Schonfeld, G., Tanoli, T., Yablonskiy, D., Yue, P.   +7 more
core   +1 more source

Elevated Linoleic Acid Intake Becomes a Risk Factor for Polycystic Ovary Syndrome by Affecting Ovarian Granulosa Cells

The FASEB Journal, Volume 39, Issue 7, 15 April 2025.
This study explored the relationship between dietary LA intake and PCOS. Animal experiments demonstrated that increased intake of LA led to PCOS‐like changes in mice, presenting with disordered estrous cycles, polycystic ovaries, and hyperandrogenism.
Wenying Zhang, Fuju Wu
wiley   +1 more source

Lemon balm extract causes potent antihyperglycemic and antihyperlipidemic effects in insulin-resistant obese mice

, 2014
Over the last decades polyetiological metabolic diseases such as obesity and type 2 diabetes have emerged as a global epidemic. Efficient strategies for prevention and treatment include dietary intervention and the development of validated nutraceuticals.
[Anon], Bailey, Berger, Bolkent, Chung, Fecka, Feldmann, Feldmann, Jun, Kliewer, Kroll, Michalik, Mueller, Muller, Pourcet, Quideau, Smyth, Spiegelman, Ulbricht, Wagner, Wegener, Weidner, Weidner   +22 more
core   +1 more source

Baicalin attenuated metabolic dysfunction‐associated fatty liver disease by suppressing oxidative stress and inflammation via the p62–Keap1–Nrf2 signalling pathway in db/db mice

Phytotherapy Research, Volume 39, Issue 4, Page 1663-1678, April 2025.
Abstract Metabolic dysfunction‐associated fatty liver disease (MAFLD) is the main cause of chronic liver disease. Baicalin (Bai), a bioactive molecule found in Scutellaria baicalensis Georgi, possesses antioxidant and antiinflammatory properties. These activities suggest Bai could be a promising therapeutic agent against NAFLD; however, its specific ...
Wen‐Jing Liu, Wei‐Wen Chen, Jia‐Ying Chen, Yi‐Bin Sun, Dennis Chang, Chen‐Xiang Wang, Jin‐Dong Xie, Wei Lin, Shao‐Hua Li, Wen Xu, Yan‐Xiang Lin, Yan‐Fang Zheng, Xian Zhou, Ming‐Qing Huang   +13 more
wiley   +1 more source

Preeclampsia is associated with compromized maternal synthesis of long chain polyunsaturated fatty acids leading to offspring deficiency [PDF]

, 2012
Obesity and excessive lipolysis are implicated in preeclampsia (PE). Intrauterine growth restriction is associated with low maternal body mass index and decreased lipolysis.
Brown, E.A., Freeman, D.J., Greer, I.A., Hodson, L., Huda, S.S., Jordan, F., Mackay, V.A., Martin, I., McKenna, L.A., Meyer, B.J., Stewart, F.M., Tham, K.   +11 more
core   +2 more sources

Variation of Meat Quality and Relationship to Gut Microbiota Among Different Pig Breeds

Microbial Biotechnology, Volume 18, Issue 4, April 2025.
Our results indicated the quality of Jinhua pigs was superior to Duroc × Berkshire × Jiaxinghei pigs and Duroc × Landrace × Yorkshire pigs, and the difference in meat quality was related to the abundance of fibre‐degrading bacteria. ABSTRACT Meat production is of great importance to the world's food supply and economic development, and meat quality ...
Qifan Zhang, Man Du, Siyu Wei, Luoyi Zhu, Rong Yan, Mingliang Jin, Yizhen Wang   +6 more
wiley   +1 more source

EPA and DHA acylcarnitines are less cardiotoxic than are saturated and monounsaturated long‐chain acylcarnitines

BioFactors, Volume 51, Issue 2, March/April 2025.
Saturated and monounsaturated acylcarnitines, particularly trans‐EC, exert significant cardiotoxic effects, primarily through the impairment of cardiac mitochondrial function. The omega‐3 PUFA‐derived acylcarnitines EPAC and DHAC are safe and less likely to damage cardiac mitochondria, cardiac cells, and the heart than other acylcarnitines.
Edgars Liepinsh, Baiba Gukalova, Kristaps Krims‐Davis, Janis Kuka, Aiga Leduskrasta, Stanislava Korzh, Reinis Vilskersts, Marina Makrecka‐Kuka, Ilze Konrade, Maija Dambrova   +9 more
wiley   +1 more source

The Role of Serum Free Fatty Acids in Endothelium‐Dependent Microvascular Function

Endocrinology, Diabetes &Metabolism, Volume 8, Issue 2, March 2025.
At baseline, free fatty acid concentration and insulin sensitivity predicted insulin‐mediated vasodilation. Acipimox and salsalate reduced free fatty acid concentration, but did not change insulin sensitivity and there was no association between the change in free fatty acids and insulin‐mediated vasodilation.
Alexander E. Sullivan, Meaghan C. S. Courvan, Aaron W. Aday, David H. Wasserman, Kevin D. Niswender, Emily M. Shardelow, Emily K. Wells, Quinn S. Wells, Matthew S. Freiberg, Joshua A. Beckman   +9 more
wiley   +1 more source

A Nonlinear Association of Body Mass Index and Fasting Blood Glucose: A Dose‐Response Analysis From Fasa Adults Cohort Study (FACS)

Health Science Reports, Volume 8, Issue 3, March 2025.
ABSTRACT Background and Aims Obesity is associated with diabetes; however, the dose–response association between body mass index (BMI) and fasting blood glucose (FBG) remains unclear. This study aims to evaluate the dose–response relationship between BMI and the risk of prediabetes and diabetes among adults.
Fatemeh Par, Fatemeh Sarvi, Mahmoud Khodadost, Babak Pezeshki, Hassan Doosti, Reza Tabrizi   +5 more
wiley   +1 more source