Results 1 to 10 of about 3,812 (172)

FDFT1 maintains glioblastoma stem cells through activation of the Akt pathway [PDF]

Stem Cell Research & Therapy
Background Cancer stem cells (CSCs) have unique metabolic characteristics and are hypothesized to contribute significantly to the recurrence and drug resistance of glioblastoma multiforme (GBM).
Hui Mo, Jiajia Shao, Zhun Li, Peiting Zeng, Xinke Yin, Yongsheng Huang, Peng Wang, Jianwei Liao   +7 more
doaj   +4 more sources

THEM6 modulates carboplatin sensitivity by regulating ferroptosis through FDFT1 in triple-negative breast cancer [PDF]

Breast Cancer Research
Background Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis, as chemotherapy resistance leads to relapse in many patients. Carboplatin addition improves treatment response, but challenges persist.
Yuexiang Zeng, Zhijie Xu, Juan Huang, Qiaoli Yi, Xi Chen, Jiayu Wang, Zhihao Du, Jian Tian, Yuanliang Yan   +8 more
doaj   +3 more sources

Valproic acid induces ferroptosis and suppresses the proliferation of MDA-MB-231 cells by targeting FDFT1 [PDF]

Frontiers in Pharmacology
IntroductionValproic acid (VPA) constitutes a branched-chain, short-chain fatty acid that serves as an antiepileptic medication. It has been increasingly recognized that VPA has presented potential anti-tumor properties, including breast cancer. However,
Shuxian Zhang, Jiazhuo Liu, Yisong Yang, Ran Tao, Xin Ren, Xingzhi Zhou, Shuangping Liu   +6 more
doaj   +3 more sources

Targeting FDFT1 Reduces Cholesterol and Bile Acid Production and Delays Hepatocellular Carcinoma Progression Through the HNF4A/ALDOB/AKT1 Axis [PDF]

Advanced Science
Targeting cholesterol metabolism is a novel direction for tumor therapy. Unfortunately, the current use of statins for hepatocellular carcinoma (HCC) is controversial.
Dong Cai, Guo‐Chao Zhong, Xin Dai, Zhibo Zhao, Menglin Chen, Jiejun Hu, Zhenru Wu, Lve Cheng, Shengwei Li, Jianping Gong   +9 more
doaj   +4 more sources

Identification of FDFT1 and PGRMC1 as New Biomarkers in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocellular Carcinoma by Deep Learning [PDF]

Journal of Hepatocellular Carcinoma
Qiqi Liu,1 Yinuo Yang,1 Yongshuai Wang,2 Shuhang Wei,1 Liu Yang,1 Tiantian Liu,1 Zhen Yu,3 Yuemin Feng,3 Ping Yao,4 Qiang Zhu1,5 1Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan ...
Liu Q, Yang Y, Wang Y, Wei S, Yang L, Liu T, Yu Z, Feng Y, Yao P, Zhu Q   +9 more
doaj   +4 more sources

Estrogen Enhances FDFT1 Expression in Theca Cells of Chicken Hierarchical Ovarian Follicles by Increasing LSD1Ser54p Level Through GSK3β Phosphorylation at 216th Tyrosine [PDF]

Biomolecules
The development of chicken ovarian follicles involves two key stages of primordial follicle recruitment and follicle selection that are tightly regulated by multiple reproductive hormones and cytokines.
Yanhong Zhang, Conghao Zhong, Xinmei Shu, Qingxin Liu, Yunliang Jiang   +4 more
doaj   +4 more sources

Lycorine hydrochloride inhibits cholangiocarcinoma through cholesterol biosynthesis and PTPN11 nuclear translocation [PDF]

Cell Communication and Signaling
Background Intrahepatic Cholangiocarcinoma (ICC) is a highly aggressive malignancy with limited treatment options. Identifying novel therapeutic agents for ICC is crucial.
Fengyun Zhao, Shuxian Peng, Liming Zou, Mingtian Zhong, Yanni Huang, Ping Wang, Mingfang Ji, Xiaodong Ma, Fugui Li   +8 more
doaj   +2 more sources

Pulsed electromagnetic stimulation promotes neuronal maturation by up-regulating cholesterol biosynthesis [PDF]

Stem Cell Research & Therapy
Background Stem cell therapies have emerged as transformative therapeutic strategies for neurological disorders. However, neurons derived from transplanted stem cells often exhibit low survival rates and remain in an immature state.
Ping Chen, Jingyi Li, Vsevolod Telezhkin, Yu Gu, Min Tao, Liping Guo, Simin Song, Rihe Dong, Xianyang Luo, Yan Wang, Qian Liu, Weiming Tian, Weihua Meng, Wei Hong, Bing Song   +14 more
doaj   +2 more sources

Ginsenoside 20(S)-Rg3 upregulates SQLE to reprogram cholesterol metabolism of ovarian cancer cells [PDF]

iScience
Summary: Ginsenoside 20(S)-Rg3 exhibits the anti-ovarian cancer activity by modulating aerobic glycolysis, but its role in reprogramming sterol metabolism remains unclear.
Fang He, Yuanyuan Zhou, Jing Fu, ShiXue Chang, Xi Cui, Zhaozu Feng, Le Zhao, Xu Li   +7 more
doaj   +2 more sources

Integrated Multi-Omics Investigation of Gypenosides’ Mechanisms in Lowering Hepatic Cholesterol [PDF]

Biomolecules
(1) Objective: This study aimed to systematically elucidate the molecular mechanisms by which gypenosides (GP), a major active component of Gynostemma pentaphyllum, ameliorate hypercholesterolemia by modulating the hepatic steroidogenesis pathway, and to
Qin Jiang, Tao Yang, Hao Yang, Yi Chen, Yuan Xiong, Lin Qin, Qianru Zhang, Daopeng Tan, Xingdong Wu, Yongxia Zhao, Jian Xie, Yuqi He   +11 more
doaj   +2 more sources