Endothelial Cells Mediated by STING Regulate Oligodendrogenesis and Myelination During Brain Development [PDF]
Advanced ScienceOligodendrocyte precursor cells (OPCs) migrate extensively using blood vessels as physical scaffolds in the developing central nervous system. Although the association of OPCs with the vasculature is critical for migration, the regulatory mechanisms ...
Wenwen Wang +13 more
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Proteomics of stress-induced cardiomyopathy: insights from differential expression, protein interaction networks, and functional pathway enrichment in an isoproterenol-induced TTC mouse model [PDF]
PeerJBackgrounds Takotsubo cardiomyopathy (TTC), also known as stress-induced cardiomyopathy, is a condition characterized by transient left ventricular dysfunction without coronary artery obstruction. Methods We utilized label-free quantitative proteomics to
Liuyang Tian +4 more
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Integrated metabolomics and proteomics analysis reveals the accumulation mechanism of bioactive components in Polygonatum odoratum [PDF]
Frontiers in Plant SciencePolygonatum odoratum (Mill.) Druce is rich in bioactive components with high medicinal value. To maximize the clinical benefits, it is of great significance to efficiently extract key bioactive components from appropriate growth stages in which they are ...
Shuang Liang +8 more
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Disrupted Lipid Metabolism Aggravates Ischemic Brain Injury: Targeting FDFT1 for Stroke Therapy. [PDF]
Mol NeurobiolYuan J +9 more
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A Method for Quantitative Analysis of Standard and High-Throughput qPCR Expression Data Based on Input Sample Quantity [PDF]
, 2014 Over the past decade rapid advances have occurred in the understanding of RNA expression and its regulation. Quantitative polymerase chain reactions (qPCR) have become the gold standard for quantifying gene expression.
Adamski, Mateusz G. +2 more
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Di-san junyi daxue xuebao, 2021 Objective To investigate the effects of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) on the growth of colorectal cancer (CRC) cell line MC-38 in vitro and in mouse models of colorectal peritoneal metastasis and xenograft tumor.
LUO Na +4 more
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Cancer Cell International, 2021 Background Fasting mimic diet is an effect approach for gastric cancer (GC) treatment. Exploring mechanisms of glucose deprivation-mediated GC suppression is required to develop novel therapeutic regimens. Farnesyltransferase 1 (FDFT1), as a novel target
Ruiyang Zhao +7 more
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Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
Cells, 2020 Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate.
Nguyen Thi Ha, Chang Hoon Lee
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Gypenosides ameliorate high-fat diet-induced nonalcoholic fatty liver disease in mice by regulating lipid metabolism [PDF]
PeerJ, 2023 Gypenosides (GP), extracted from the traditional Chinese herb Gynostemma pentaphyllum (Thunb.) Makino, have been used to treat metabolic disorders, including lipid metabolism disorders and diabetes. Although recent studies have confirmed their beneficial
Tingting Zhou +7 more
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Gene Expression Profiles Modulated by Lipophilic Sea Buckthorn (<i>Hippophae rhamnoides</i> L.) Extract in BT-549 Triple-Negative Breast Cancer Cells. [PDF]
Food Sci NutrTranscriptomic profiling showed that carotenoid‐rich lipophilic sea buckthorn extract (LSBE) significantly altered genes controlling cholesterol metabolism, mTORC1 signaling, oxidative stress, and ferroptosis in BT‐549 TNBC cells. These findings generate mechanistic hypotheses for LSBE as a potential complementary approach in TNBC therapy, pending ...
Visan S +4 more
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