Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis. [PDF]
, 2018 RationaleThe monitoring of TB treatments in clinical practice and clinical trials relies on traditional sputum-based culture status indicators at specific time points.
Baker, Erin S +14 more
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The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells [PDF]
, 2016 Pentraxin 3 (PTX3) is a fluid-phase pattern recognition receptor of the humoral innate immune system with ancestral antibody-like properties but unknown antibody-inducing function.
A. Cooper Walland +24 more
core +3 more sources
, 2009 Histidine-rich glycoprotein (HRG) is an abundant multi-functional protein that is present in the plasma of many vertebrates. HRG has a multi-domain structure that allows the molecule to interact with many ligands including heparin, heparan sulfate (HS ...
Poon, Ivan Ka Ho
core +1 more source
Local inflammation induces complement crosstalk which amplifies the antimicrobial response.
PLoS Pathogens, 2009 By eliciting inflammatory responses, the human immunosurveillance system notably combats invading pathogens, during which acute phase proteins (CRP and cytokines) are elevated markedly.
Jing Zhang +8 more
doaj +1 more source
The role of human ficolin-2 during invasive pneumococcal disease [PDF]
, 2014 Streptococcus pneumoniae (pneumococcus) is a significant human pathogen that typically resides in the nasopharynx of humans. The major virulence factor of pneumococcus is its capsular polysaccharide, of which it can express over 90 unique serotypes ...
Brady, Allison Marie
core +1 more source
Anti-ficolin-2 Antibody: Could it be a Predictor of Proliferative Lupus Nephritis in Lupus Patients? [PDF]
, 2022 Background: Nephritis is a challenging domain of systemic lupus erythematosus (SLE). There is a growing need for identification of a non-invasive marker for diagnosing and monitoring nephritis.Objective: To explore the relevance of using anti-ficolin-2 ...
Ahmed, Fatma Abdelrahman +4 more
core +1 more source
Exploring complement biomarkers in suspected axial spondyloarthritis
RMD OpenObjectives To investigate lectin pathway proteins (LPPs) as biomarkers for axial spondyloarthritis (axSpA) in a cross-sectional cohort with a suspicion of axSpA, comprising newly diagnosed axSpA and chronic low back pain (cLBP) individuals.Methods Serum ...
Joachim Sieper +13 more
doaj +1 more source
The genomic Make-Up of a Hybrid Species - Analysis of the Invasive Cottus Lineage (Pisces, Teleostei) in the River Rhine system [PDF]
, 2007 In the past years a new invasive lineage of sculpins (Cottus species complex) has been studied that is currently expanding in the Lower River Rhine. Molecular analysis showed that this lineage has originated through hybridization of Cottus perifretum ...
Stemshorn, Kathryn
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C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules
Frontiers in Immunology, 2018 Complement receptor type 1 (CR1) is a multi modular membrane receptor composed of 30 homologous complement control protein modules (CCP) organized in four different functional regions called long homologous repeats (LHR A, B, C, and D). CR1 is a receptor
Mickaël Jacquet +6 more
doaj +1 more source
Troubleshooting methods for the generation of novel pseudotyped viruses [PDF]
, 2016 A pseudotyped virus (PV) is a virus particle with an envelope protein originating from a different virus. The ability to dictate which envelope proteins are expressed on the surface has made pseudotyping an important tool for basic virological studies ...
Daly, Janet M. +6 more
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