Results 101 to 110 of about 5,605 (194)

Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults

Immunity & Ageing, 2020
Background There is increasing recognition of the significance of chronic, low-level inflammation in older adults, or “inflammaging.” Innate immune responses and host-bacterial interactions are recognized as key factors in inflammaging.
David C. LaFon, Steffen Thiel, Young-il Kim, Mark T. Dransfield, Moon H. Nahm   +4 more
doaj   +1 more source

MASP-1 and MASP-2 Do Not Activate Pro-Factor D in Resting Human Blood, whereas MASP-3 Is a Potential Activator: Kinetic Analysis Involving Specific MASP-1 and MASP-2 Inhibitors. [PDF]

, 2016
It had been thought that complement factor D (FD) is activated at the site of synthesis, and only FD lacking a propeptide is present in blood. The serum of mannose-binding lectin-associated serine protease (MASP)-1/3(-/-) mice contains pro-FD and has ...
Andrea Kocsis, Anne Zeck, Dávid Szakács, Elod Kortvely, Gábor Oroszlán, Gábor Pál, József Dobó, Marius Ueffing, Péter Gál, Péter Závodszky, Sascha Dammeier   +10 more
core   +1 more source

Complement and transplant‐associated thrombotic microangiopathy: Current and future approaches

HemaSphere, Volume 10, Issue 4, April 2026.
Massimo Cugno, Francesco Onida, Bernhard Lämmle   +2 more
wiley   +1 more source

The Complement System in ANCA‐Associated Vasculitis: Mechanistic Insights, Therapeutic Horizons, and Unmet Clinical Needs

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
Complement activation, particularly via the alternative pathway, drives inflammation and organ damage in ANCA‐associated vasculitis. This review highlights mechanistic insights, tissue and biomarker evidence, and clinical implications of targeting the C5a–C5aR1 axis.
Kehinde Sunmboye, Pauline Millan
wiley   +1 more source

Prospective assessment of risk biomarkers of sinusoidal obstruction syndrome after hematopoietic cell transplantation

JCI Insight, 2023
BACKGROUND Currently, no laboratory tests exist to stratify for the risk of developing sinusoidal obstruction syndrome (SOS), an early endothelial complication after hematopoietic cell transplantation (HCT).
Yan Han, Alan Bidgoli, Brittany P. DePriest, Alejandra Méndez, Khadijeh Bijangi-Vishehsaraei, Evelio D. Perez-Albuerne, Robert A. Krance, Jamie Renbarger, Jodi L. Skiles, Sung W. Choi, Hao Liu, Sophie Paczesny   +11 more
doaj   +1 more source

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Sinapine Modulates Glycogen and Lipid Synthesis via IRS1–PI3K–AKT–GSK3β–GS Pathway in Insulin‐Resistant Models

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
This study combined network pharmacology, molecular docking, and in vitro (HepG2) and in vivo (T2DM mice) experiments to investigate sinapine's effect on insulin resistance. Sinapine was found to modulate the IRS1–PI3K–AKT–GSK3β–GS pathway. In vitro, sinapine improved glucose uptake, enhanced glycogen synthesis, and reduced lipogenesis and ROS. In vivo,
Tiancheng Xing, Yiling Bai, Weijie Wu, Ziqi Zhao, Hanyu Kong, Qianyi Zhang, Shuoqi Li, Yan Liu, Xiaohui Guo, Zengli Wang   +9 more
wiley   +1 more source

Reliable and rapid characterization of functional FCN2 gene variants reveals diverse geographical patterns

BMC Medical Genetics, 2012
Background Ficolin-2 coded by FCN2 gene is a soluble serum protein and an innate immune recognition element of the complement system. FCN2 gene polymorphisms reveal distinct geographical patterns and are documented to alter serum ficolin levels and ...
Ojurongbe Olusola, Ouf Eman, Van Tong Hoang, Toan Nguyen L, Song Le H, Luz Paola R, Messias-Reason Iara JT, Nurjadi Dennis, Zanger Philipp, Kun Jürgen FJ, Kremsner Peter G, Velavan Thirumalaisamy P   +11 more
doaj   +1 more source

Ficolin-A induces macrophage polarization to a novel pro-inflammatory phenotype distinct from classical M1

Cell Communication and Signaling
Background Macrophages are key inflammatory immune cells that orchestrate the initiation and progression of autoimmune diseases. The characters of macrophage in diseases are determined by its phenotype in response to the local microenvironment.
Li-Wen Zhu, Zihao Li, Xiaohong Dong, Huadong Wu, Yifan Cheng, Shengnan Xia, Xinyu Bao, Yun Xu, Runjing Cao   +8 more
doaj   +1 more source

The Lectin Pathway of Complement and Rheumatic Heart Disease

Frontiers in Pediatrics, 2015
The innate immune system is the first line of host defense against infection and is comprised of humoral and cellular mechanisms that recognize potential pathogens within minutes or hours of entry.
Marcia Holsbach Beltrame, Sandra Jeremias Catarino, Isabela eGoeldner, Angelica Beate Winter Boldt, Iara eDe Messias Reason   +4 more
doaj   +1 more source