Results 81 to 90 of about 5,605 (194)
Frontiers in Immunology, 2018 The complement system is a key component of the innate immune system, participating in the surveillance against infectious agents. Once activated by one of the three different pathways, complement mediates cell lysis, opsonization, signalizes pathogens ...
Maria Regina Tizzot +8 more
doaj +1 more source
Genetic variants of innate immune receptors and infections after liver transplantation. [PDF]
, 2017 Infection is the leading cause of complication after liver transplantation, causing morbidity and mortality in the first months after surgery. Allograft rejection is mediated through adaptive immunological responses, and thus immunosuppressive therapy is
Cervera, Carlos +4 more
core +1 more source
Genetic Polymorphism of Ficolin-2 in Arctic Populations
Doctor.RuAim. To study the prevalence of polymorphisms rs17549193 and rs7851696 of the ficolin-2 gene FCN2 among the Nenets, Dolgan-Nganasan and Slavic populations using a molecular genetic study of single nucleotide polymorphisms. Design. Comparative population-genetic research. Materials and methods.
K.V. Afonicheva +3 more
openaire +1 more source
Synergy between Ficolin-2 and Pentraxin 3 Boosts Innate Immune Recognition and Complement Deposition [PDF]
Journal of Biological Chemistry, 2009 The long pentraxin 3 (PTX3) is a multifunctional soluble pattern recognition molecule that is crucial in innate immune protection against opportunistic fungal pathogens such as Aspergillus fumigatus. The mechanisms that mediate downstream effects of PTX3 are largely unknown. However, PTX3 interacts with C1q from the classical pathway of the complement.
Ma, Ying Jie +7 more
openaire +4 more sources
Yersinia enterocolitica O:3 Outer Membrane Vesicles as a Platform for Complement Activation
Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.Basic characteristics and biological activity of outer membrane vesicles (OMVs) secreted by Yersinia enterocolitica O:3 (YeO3), depending on LPS chemotype and growth temperature. ABSTRACT Lipopolysaccharide (LPS) is the major component of the outer membrane vesicles (OMVs) of Gram‐negative bacteria.
Cédric Battaglino +15 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.Proteomic profiling of tissue explant‐ and plasma‐derived extracellular vesicles identified colon adenocarcinoma‐associated and healthy‐associated EV proteins. A 10‐protein EV panel enabled highly sensitive blood‐based detection of colon adenocarcinoma, showed marked postoperative changes, and retained performance in an independent validation cohort ...
Yura Seo +33 more
wiley +1 more source
Effects of sequence variations in innate immune response genes on infectious outcome in trauma patients: A comprehensive review [PDF]
, 2015 Infectious complications, sepsis, and multiple organ dysfunction syndrome (MODS) remain important causes for morbidity and mortality in patients who survive the initial trauma.
Bronkhorst, M.W.G.A. (Maarten) +2 more
core +1 more source
FASEB BioAdvances, Volume 8, Issue 4, April 2026.The graphical abstract contrasts normal and fibrotic lungs, illustrating how miR‐200a mimics suppress PAI‐1 and EMT markers, restore fibrinolysis, and reduce MMP‐driven ECM deposition. This schematic highlights the therapeutic potential of miR‐200a in mitigating pulmonary fibrosis progression.
T. M. Jeena +7 more
wiley +1 more source
PLoS ONE, 2016 Despite recombinant protein technology development, proteins isolated from natural sources remain important for structure and activity determination. Ficolins represent a class of proteins that are difficult to isolate.
Aleksandra Man-Kupisinska +6 more
doaj +1 more source
Proteomic analysis of silica hybrid sol-gel coatings: a potential tool for predicting the biocompatibility of implants in vivo [PDF]
, 2017 The interactions of implanted biomaterials with the host organism determine the success or failure of an implantation. Normally, their biocompatibility is assessed using in vitro tests.
Azkargorta, Mikel +8 more
core +1 more source