The serum opsonin L-ficolin is detected in lungs of human transplant recipients following fungal infections and modulates inflammation and killing of Aspergillus fumigatus. [PDF]
, 2015 BACKGROUND: Invasive aspergillosis (IA) is a life-threatening systemic fungal infection in immunocompromised individuals that is caused by Aspergillus fumigatus. The human serum opsonin, L-ficolin, has been observed to recognize A.
Abdolrasouli, A +6 more
core +2 more sources
Proteolytic remodelling of the extracellular matrix by pericytes
The FEBS Journal, EarlyView.Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source
Ficolin 2 (FCN2) functional polymorphisms and the risk of rheumatic fever and rheumatic heart disease [PDF]
Clinical and Experimental Immunology, 2009 Summary Ficolins are pattern-recognition proteins involved in innate immunity, which upon binding to their specific pathogen-associated molecular patterns on the microbial surfaces trigger the immune response either by binding to collectin cellular receptors or by initiating the complement lectin pathway.
I J, Messias-Reason +3 more
openaire +2 more sources
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT Reliable biomarkers that enable noninvasive, longitudinal assessment of disease activity and therapeutic response remain a major unmet need in inflammatory bowel disease (IBD). While colonic biopsies are the gold standard for evaluating mucosal inflammation, their invasive nature and limited spatial and temporal resolution constrain their ...
Mohamed Hassanein +8 more
wiley +1 more source
AmpliSeq screening of genes encoding the C-Type lectin receptors and their signaling components reveals a common variant in MASP1 associated with pulmonary tuberculosis in an Indian population [PDF]
, 2018 Tuberculosis (TB) is a multifactorial disease governed by bacterial, host and environmental factors. On the host side, growing evidence shows the crucial role that genetic variants play in the susceptibility to Mycobacterium tuberculosis (Mtb) infection.
Abid Hussain +14 more
core +6 more sources
BMC Cancer, 2018 Background Radiofrequency ablation (RFA) can not only effectively kill hepatocellular carcinoma (HCC) tumour cells but also release tumour antigens that can provoke an immune response.
Shunli Shen +7 more
doaj +1 more source
Genetic mannose binding lectin deficiency is associated with airway microbiota diversity and reduced exacerbation frequency in COPD [PDF]
, 2017 BACKGROUND: In cystic fibrosis and bronchiectasis, genetic mannose binding lectin (MBL) deficiency is associated with increased exacerbations and earlier mortality; associations in COPD are less clear.
Adrian Hapca +18 more
core +2 more sources
Functional Haplotypes That Produce Normal Ficolin‐2 Levels Protect against Clinical Leprosy [PDF]
The Journal of Infectious Diseases, 2009 Host factors have been shown to play a significant role in the susceptibility to and clinical outcome of leprosy. Here, we analyze polymorphisms of the gene encoding ficolin-2 (FCN2), which is a soluble pattern-recognition molecule. A total of 158 patients with leprosy and 210 healthy control subjects from Brazil were investigated. Polymorphisms in the
Iara, de Messias-Reason +2 more
openaire +2 more sources
The FASEB Journal, Volume 40, Issue 8, 30 April 2026.Graphical abstract illustrating the barrier defense–tolerance framework of reproductive innate immunity. Across the female and male reproductive tracts and the maternal–fetal interface, epithelial barriers, innate sensors, immune cells, and microbial signals are integrated to preserve reproductive homeostasis.
Xianlin Rao +3 more
wiley +1 more source
Mannose-binding lectin deficiency is associated with myocardial infarction: the HUNT2 study in Norway. [PDF]
PLoS ONE, 2012 OBJECTIVES: Mannose-binding lectin (MBL) and ficolins activate the complement cascade, which is involved in atherogenesis. Based on a pilot study, we hypothesized that functional polymorphisms in the MBL gene (MBL2) leading to dysfunctional protein are ...
Inga Thorsen Vengen +5 more
doaj +1 more source