Results 21 to 30 of about 7,998 (276)
Exploring complement biomarkers in suspected axial spondyloarthritis [PDF]
RMD OpenObjectives To investigate lectin pathway proteins (LPPs) as biomarkers for axial spondyloarthritis (axSpA) in a cross-sectional cohort with a suspicion of axSpA, comprising newly diagnosed axSpA and chronic low back pain (cLBP) individuals.Methods Serum ...
Joachim Sieper +13 more
doaj +2 more sources
Genetic evidence of functional ficolin-2 haplotype as susceptibility factor in cutaneous leishmaniasis. [PDF]
PLoS ONE, 2012 BackgroundFicolin-2 coded by FCN2 gene is a soluble serum protein that plays an important role in innate immunity. In this study, we analyzed five functional polymorphisms of the FCN2 gene for their possible association with cutaneous leishmaniasis ...
Amal Assaf +6 more
doaj +3 more sources
Journal of Innate Immunity, 2009 Udgivelsesdato: 2009 ...
Peter Garred, Niels Borregaard
openalex +5 more sources
The Disulfide Bonding Pattern in Ficolin Multimers [PDF]
Journal of Biological Chemistry, 2004 Ficolin is a plasma lectin, consisting of a short N-terminal multimerization domain, a middle collagen domain, and a C-terminal fibrinogen-like domain. The collagen domains assemble the subunits into trimers, and the N-terminal domain assembles four trimers into 12-mers.
Tomoo Ohashi, Harold Erickson
openalex +4 more sources
Circulating Ficolin-2 and Ficolin-3 Form Heterocomplexes [PDF]
The Journal of Immunology, 2020 Abstract The complement system constitutes an important part of the innate immune system. The collectins and the ficolins are soluble pattern recognition molecules that contribute to complement activation via the lectin pathway. During previous experiments with ficolin-2 and ficolin-3, we have observed that the molecules may interact. We
Ida Jarlhelt +5 more
openaire +4 more sources
Rapid and Simultaneous Detection of Dengue and Chikungunya Viruses by a Multiplex Lateral Flow Assay Using Ficolin-1, One of Human Innate Immune Defense Proteins [PDF]
Journal of Bacteriology and Virology, 2022 license/by-nc/3.0/). The infection of dengue virus (DENV) and chikungunya virus (CHIKV) can cause global public health problems, many of which are undifferentiated. Thus, their differential diagnosis is critical to proper patient management.
So Yeon Yi +5 more
openalex +2 more sources
Cell Death and Disease, 2023 Pathogenesis exploration and timely intervention of lung injury is quite necessary as it has harmed human health worldwide for years. Ficolin B (Fcn B) is a recognition molecule that can recognize a variety of ligands and play an important role in ...
Xu Wu +7 more
semanticscholar +1 more source
Anti-Ficolin-2 and Anti-Ficolin-3 Autoantibody Detection by ELISA [PDF]
, 2021 Ficolins are recognition proteins of the lectin pathway of the complement system and also play an important role in innate immunity and in the maintenance of tissue homeostasis. They deserve special attention in the context of autoimmunity since they are involved in the uptake of dying cells. Because the monitoring of systemic lupus erythematosus (SLE)
Dumestre-Pérard, Chantal +1 more
openaire +3 more sources
The Role of Ficolins in Lung Injury. [PDF]
J Innate ImmunBackground: Respiratory diseases seriously threaten human health worldwide, and lung injury is an important component of respiratory disease. Complement activation is an important function of the innate immune system. Complement activation helps the body defend against invasion by external microorganisms, whereas excessive complement activation can ...
Zhao M, Tan X, Wu X.
europepmc +4 more sources
Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans. [PDF]
PLoS ONE, 2013 Human ficolin-2 (ficolin-2/P35) is a lectin complement pathway activator that is present in normal human plasma and is associated with infectious diseases; however, little is known regarding the roles and mechanisms of ficolin-2 during Mycobacterium ...
Fengling Luo +7 more
doaj +1 more source