Results 41 to 50 of about 5,314 (149)

The Lectin Complement Pathway Is Involved in Protection Against Enteroaggregative Escherichia coli Infection

Frontiers in Immunology, 2018
Enteroaggregative Escherichia coli (EAEC) causes acute and persistent diarrhea worldwide. Still, the involvement of host factors in EAEC infections is unresolved. Binding of recognition molecules from the lectin pathway of complement to EAEC strains have
Camilla Adler Sørensen, Camilla Adler Sørensen, Anne Rosbjerg, Betina Hebbelstrup Jensen, Karen Angeliki Krogfelt, Peter Garred   +5 more
doaj   +1 more source

Integrated Network Pharmacology, Single‐Cell Transcriptomics Unveil the Mechanistic Role of Morusin in Aortic Dissection

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Aortic dissection is a life‐threatening cardiovascular emergency with limited pharmacological options. This study focuses on elucidating the multi‐target and multi‐pathway mechanisms through which morusin mitigates aortic dissection progression, integrating network pharmacology, single‐cell transcriptomics and experimental validation.
Zhaomeng Wang, Haoran Zhang, Zhanxiong Xie, Yukun Xiang, Yiwen Fu, Zixun Wang, Haiqing Jiao, Nan Lin, Chenguang Niu, Chao Jiang, Lemin Zheng   +10 more
wiley   +1 more source

Associations of Ficolins With Hematological Malignancies in Patients Receiving High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantations

Frontiers in Immunology, 2020
A prospective study of 312 patients [194 with multiple myeloma (MM) and 118 with lymphomas (LYMPH)] receiving high-dose chemotherapy and autologous hematopoietic stem cell transplantation (auto-HSCT) was conducted.
Anna S. Świerzko, Mateusz Michalski, Anna Sokołowska, Mateusz Nowicki, Agnieszka Szala-Poździej, Łukasz Eppa, Iwona Mitrus, Anna Szmigielska-Kapłon, Małgorzata Sobczyk-Kruszelnicka, Katarzyna Michalak, Aleksandra Gołos, Agnieszka Wierzbowska, Sebastian Giebel, Krzysztof Jamroziak, Marek L. Kowalski, Olga Brzezińska, Olga Brzezińska, Steffen Thiel, Misao Matsushita, Jens C. Jensenius, Gabriela Gajek, Maciej Cedzyński   +21 more
doaj   +1 more source

Revealing the Action Mechanism of Exogenous Hydrogen Sulfide Intervention in Colorectal Cancer Pathogenesis Based on Multiomics Analysis and Experimental Validation

Human Mutation, Volume 2026, Issue 1, 2026.
Colorectal cancer (CRC) ranks among the leading causes of cancer‐related mortality worldwide. Hydrogen sulfide (H2S) has been found to possess a characteristic of anticancer, which may offer a potential novel treatment for CRC. Here, we discover the potential targets and mechanism of H2S intervention in CRC employing multiomics analysis and ...
Facai Cui, Chen Yu, Weifeng Zhao, Juan Shi, Yang Liu, Fengzhen Liu, Sujit Nair   +6 more
wiley   +1 more source

Association of Ficolin-2 Serum Levels and FCN2 Genetic Variants with Indian Visceral Leishmaniasis. [PDF]

PLoS ONE, 2015
Visceral leishmaniasis (VL), one of the neglected tropical diseases, is endemic in the Indian subcontinent. Ficolins are circulating serum proteins of the lectin complement system and involved in innate immunity.We have estimated ficolin-2 serum levels ...
Anshuman Mishra, Justin S Antony, Pandarisamy Sundaravadivel, Hoang Van Tong, Christian G Meyer, Reshma D Jalli, Thirumalaisamy P Velavan, Kumarasamy Thangaraj   +7 more
doaj   +1 more source

Construction of a Mitochondria‐Related Gene Diagnostic Model Based on Integrated Multiomics Data and Functional Validation of ANK2 as a Key Regulator in Colorectal Cancer

International Journal of Genomics, Volume 2026, Issue 1, 2026.
Colorectal cancer (CRC) is one of the most common malignancies of the digestive tract globally, characterized by high incidence, difficulty in early diagnosis, and poor prognosis. Traditional screening methods have limitations in sensitivity and specificity, thus necessitating the development of novel, efficient molecular diagnostic approaches.
Xiangyu Ding, Huanhuan Wu, Jiyuan Yang, Han Song, Jianhui Guo, Xudong Wang, Xiaopeng Zhang, Zhengrui Li   +7 more
wiley   +1 more source

Potassium Sorbate Triggers Kidney Injury via Dysregulated Intercellular Communication: A Study Combining Network Toxicology, Machine Learning, Molecular Docking, and Single‐Cell RNA Sequencing

iMetaMed, Volume 1, Issue 2, December 2025.
Amyloid precursor protein (APP)‐mediated endothelial‐immune cell crosstalk is a novel mechanism for potassium sorbate‐induced renal injury. Multi‐omics integration (network toxicology, machine learning, scRNA‐seq) uncovers this interaction via APP‐CD74/PTGER2 axes, linking oxidative stress and inflammation to renal damage. ABSTRACT Acute kidney injury (
Yimao Wu, Yalun Liang, Jintao Liang, Gokhan Zengin, Qian Zhang, Meng‐Yao Li   +5 more
wiley   +1 more source

Insufficient serum L-ficolin is associated with disease presence and extent of pulmonary Mycobacterium avium complex disease

Respiratory Research, 2019
Background The incidence of infectious disease caused by nontuberculous mycobacteria is increasing worldwide. Pulmonary Mycobacterium avium complex (MAC) disease is difficult to treat with chemotherapy, and its mechanism of infection, infection route ...
Tomofumi Kobayashi, Koji Kuronuma, Atsushi Saito, Kimiyuki Ikeda, Shigeru Ariki, Atsushi Saitou, Mitsuo Otsuka, Hirofumi Chiba, Satoshi Takahashi, Motoko Takahashi, Hiroki Takahashi   +10 more
doaj   +1 more source

Mouse mannose-binding lectin-A and ficolin-A inhibit lipopolysaccharide-mediated pro-inflammatory responses on mast cells [PDF]

BMB Reports, 2013
It is unknown how soluble pattern-recognition receptors inblood, such as mannose-binding lectin (MBL) and ficolins,modulate mast cell-mediated inflammatory responses. Weinvestigate how mouse MBL-A or ficolin-A regulate mouse bonemarrow-derived mast cells
Ying Jie Ma, Hee Jung Kang, Ji Yeon Kim, Peter Garred, Myung-Shik Lee, Bok Luel Lee   +5 more
doaj   +1 more source

Proteomic Identification of Plasma Biomarkers of Response to IL‐5 Inhibitor Biologics in Healthy Subjects

Clinical and Translational Science, Volume 18, Issue 12, December 2025.
ABSTRACT Proteomics can identify pharmacodynamic (PD) biomarkers by detecting protein changes in response to drug treatment, providing insights into drug mechanism and biological effects. In this study, we profiled over 7000 plasma proteins to identify potential PD biomarkers for the interleukin‐5 (IL‐5) inhibitors mepolizumab and reslizumab, which are
Lakshmi Manasa S. Chekka, Deepti P. Samarth, Kristina E. Howard, Yan Guo, Esraa G. Mohamed, Erica Decker, William Wheeler, Joel Wommack, Joseph Gogain, Jennifer Deering, Sarah J. Schrieber, Yow‐Ming Wang, David G. Strauss, Jeffry Florian, Paula L. Hyland   +14 more
wiley   +1 more source