Results 61 to 70 of about 5,314 (149)

Ficolins do not alter host immune responses to lipopolysaccharide-induced inflammation in vivo

Scientific Reports, 2017
Ficolins are a family of pattern recognition molecules that are capable of activating the lectin pathway of complement. A limited number of reports have demonstrated a protective role of ficolins in animal models of infection.
Ninette Genster, Olga Østrup, Camilla Schjalm, Tom Eirik Mollnes, Jack B. Cowland, Peter Garred   +5 more
doaj   +1 more source

Immunoglobulin A Nephropathy: Molecular Pathogenesis and Targeted Therapy

MedComm, Volume 6, Issue 9, September 2025.
The future of IgAN treatment likely involves combining several therapies to target multiple disease mechanisms simultaneously. Clinical trials are ongoing to evaluate the efficacy and safety of various combinations. As our understanding of IgAN pathogenesis evolves, more targeted and personalized treatment strategies are expected to emerge.
Xu‐Jie Zhou
wiley   +1 more source

Role of Toll‐Like Receptors in Myeloid Neoplasms: Focuses on the Molecular Mechanisms and Clinical Impact on Myelodysplastic Syndromes, Acute Myeloid Leukemia, and Chronic Myeloid Leukemia

APMIS, Volume 133, Issue 9, September 2025.
ABSTRACT Toll‐like receptors (TLRs) are essential components of the innate immune system, functioning as pattern recognition receptors (PRRs) to detect pathogen‐associated molecular patterns (PAMPs) and damage‐associated molecular patterns (DAMPs). In hematological malignancies, particularly myelodysplastic syndromes (MDS), acute myeloid leukemia (AML),
Clarissa Brenda Alves Cavalcante, Alessandro Cavalcante Chaves, Vanessa Silva de Oliveira, Maria Amanda Silva de Araújo, Thayres Marinho Cunha e Silva, João Vitor Caetano Goes, Roberta Taiane Germano de Oliveira, Ronald Feitosa Pinheiro, Howard Lopes Ribeiro‐Junior   +8 more
wiley   +1 more source

Clusterin and pentraxin 3 are markers of severity during febrile neutropenia in adults with haematological malignancies receiving intensive chemotherapy

British Journal of Haematology, Volume 207, Issue 3, Page 780-788, September 2025.
During febrile neutropenia in patients with haematological malignancies, pentraxin 3 (PTX3), a soluble innate immunity receptor, increases with severe sepsis, while clusterin, a chaperon protein involved in extracellular histones clearance, decreases in patients with quick SOFA score (qSOFA) ≥2.
Coralie Mallebranche, Carole Mosnier, Corentin Orvain, Jérémie Riou, Sylvain Thepot, Pascale Pignon, Simon Blanchard, Nathalie Tortevoie, Isabelle Pellier, Mathilde Hunault‐Berger, Pascale Jeannin, Yves Delneste, Aline Schmidt‐Tanguy, Céline Beauvillain   +13 more
wiley   +1 more source

Novel Polymorphism in a Promoter of MBL2 Gene Result in Lower MBL Expression in Chronic Infection Caused by HCV

Kurdistan Journal of Applied Research, 2020
The Pathogen Recognition Receptors (PRRs) is an active protein in the immune system. The PRRs that secreted in the liver and we addressed were L-ficolin, MBL and H-ficolin. Previous studies revealed that both MBL and L-ficolin were hampered the HCV entry
Paywast Jamal Jalal
doaj   +1 more source

Ficolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway [PDF]

, 2023
Wu Xu, Yixia Jiang, Rong Li, Yezhou Xia, Feifan Li, Meiyun Zhao, Guoqing Li, Xiaowu Tan   +7 more
openalex   +1 more source

Data from LncRNA <i>AK036396</i> Inhibits Maturation and Accelerates Immunosuppression of Polymorphonuclear Myeloid–Derived Suppressor Cells by Enhancing the Stability of Ficolin B

, 2023
Xinyu Tian, Yu Zheng, Kai Yin, Jie Ma, Jie Tian, Yue Zhang, Lingxiang Mao, Huaxi Xu, Shengjun Wang   +8 more
openalex   +1 more source

Decision letter for "Ficolin‐3 in chronic Chagas disease: low serum levels associated with the risk of cardiac insufficiency"

, 2021

openalex   +1 more source

Ficolin B in Diabetic Kidney Disease in a Mouse Model of Type 1 Diabetes

Mediators of Inflammation, 2015
Background. The innate immune system may have adverse effects in diabetes and cardiovascular disease. The complement system seems to play a key role through erroneous complement activation via hyperglycaemia-induced neoepitopes.
Charlotte Berg Holt, Jakob Appel Østergaard, Esben Axelgaard, Gitte Krogh Nielsen, Yuichi Endo, Steffen Thiel, Troels Krarup Hansen   +6 more
doaj   +1 more source

Plasma levels of H- and L-ficolin are increased in axial spondyloarthritis: improvement of disease identification [PDF]

, 2019
Anne Troldborg, Steffen Thiel, Clara Elbæk Mistegaard, Anette Tarp Hansen, T-L Korsholm, K. Stengaard‐Pedersen, Anne Gitte Loft   +6 more
openalex   +1 more source