Results 61 to 70 of about 7,998 (276)

Ficolin-2 binds to serotype 35B pneumococcus as it does to serotypes 11A and 31, and these serotypes cause more infections in older adults than in children.

PLoS ONE, 2018
Among 98 serotypes of Streptococcus pneumoniae, only a small subset regularly causes invasive pneumococcal diseases (IPD). We previously demonstrated that serotype 11A binds to ficolin-2 and has low invasiveness in children. Epidemiologic data suggested,
K Aaron Geno, Brady L Spencer, Sejong Bae, Moon H Nahm   +3 more
doaj   +1 more source

Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults

Scientific Reports, 2020
We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as ...
Anna Sokołowska, Anna S. Świerzko, Gabriela Gajek, Aleksandra Gołos, Mateusz Michalski, Mateusz Nowicki, Agnieszka Szala-Poździej, Anna Wolska-Washer, Olga Brzezińska, Agnieszka Wierzbowska, Krzysztof Jamroziak, Marek L. Kowalski, Steffen Thiel, Misao Matsushita, Jens C. Jensenius, Maciej Cedzyński   +15 more
doaj   +1 more source

Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis

Journal of experimental & clinical cancer research : CR
Background Targeting ferroptosis has been identified as a promising approach for the development of cancer therapies. Monounsaturated fatty acid (MUFA) is a type of lipid that plays a crucial role in inhibiting ferroptosis.
Yanmei Yuan, Junting Xu, Quanxin Jiang, Chuanxin Yang, Ning Wang, Xiaolong Liu, Hai-long Piao, Sijia Lu, Xianjing Zhang, Liu Han, Zhiyan Liu, Jiabin Cai, Fang Liu, Suzhen Chen, Junli Liu   +14 more
semanticscholar   +1 more source

A Computational and Experimental Study of the Regulatory Mechanisms of the Complement System [PDF]

, 2010
The complement system is key to innate immunity and its activation is necessary for the clearance of bacteria and apoptotic cells. However, insufficient or excessive complement activation will lead to immune-related diseases. It is so far unknown how the
A Krarup, A Thern, AA Korotaevskiy, AF Zadura, AM Blom, AM Blom, AM Blom, Anna M. Blom, AP Sjoberg, AP Sjoberg, B Dahlback, B Liu, B Selander, Benjamin Leong, Bing Liu, Bow Ho, C Mold, CJ Langmead, D Ricklin, D Sheskin, David Hsu, DH Anderson, DT Fearon, DT Fearon, G Koh, H Hirayama, I Gigli, I Gigli, J Gunawardena, J Scharfstein, J Zhang, Jeak Ling Ding, JH Griffin, Jing Zhang, K Berggard, KP Murphy, KP Murphy, L Marnell, L Truedsson, LM Boerger, M Bozga, M Jaeger, M Matsushita, M Okroj, MH Kaplan, MJ Walport, MJ Walport, MV Suresh, N Rawal, NA van Riel, NV Prasadarao, P. S. Thiagarajan, Pei Yi Tan, PM Ng, R Veerhuis, Rustom Antia, S Hoops, S Jha, S Ram, SR Barnum, Sunil Sethi, T Fujita, T Meri, T Nordstrom, V Kirjavainen, X Ji, Z Fishelson, Z Zi   +67 more
core   +4 more sources

Identification of the mouse H-ficolin gene as a pseudogene and orthology between mouse ficolins A/B and human L-/M-ficolins

Genomics, 2004
Ficolin is a collagenous lectin which plays a crucial role in innate immunity. Three and two ficolins have been identified in human and mice, respectively. To identify the mouse homologue of human H-ficolin and to elucidate the orthology between mouse ficolins A/B and human L-/M-ficolins, the gene structures were explored.
Kazuko Kanno, Minoru Takahashi, Teizo Fujita, Yu Liu, Yuichi Endo, Misao Matsushita   +5 more
openaire   +3 more sources

Human Lectins and Their Roles in Viral Infections

Molecules, 2015
Innate recognition of virus proteins is an important component of the immune response to viral pathogens. A component of this immune recognition is the family of lectins; pattern recognition receptors (PRRs) that recognise viral pathogen-associated ...
Christopher P. Mason, Alexander W. Tarr
doaj   +1 more source

Association of a new FCN3 haplotype with high ficolin-3 levels in leprosy. [PDF]

PLoS Neglected Tropical Diseases, 2017
Leprosy is a chronic inflammatory disease caused by Mycobacterium leprae that mainly affects the skin and peripheral nervous system, leading to a high disability rate and social stigma.
Fabiana Antunes Andrade, Marcia Holsbach Beltrame, Valéria Bumiller Bini, Letícia Boslooper Gonçalves, Angelica Beate Winter Boldt, Iara Jose de Messias-Reason   +5 more
doaj   +1 more source

Changes of Serum Ficolin-3 and C5b-9 in Patients with Heart Failure

Pakistan Journal of Medical Sciences, 2021
Objectives: To investigate the correlation of serum ficolin-3 and C5b-9 with cardiac function and NT-proBNP in patients with heart failure. Methods: Sixty patients with heart failure admitted to the Baoding First Central Hospital from May 2019 to May ...
Hongli Li, Fangfang Zhang, Dan Zhang, X. Tian   +3 more
semanticscholar   +1 more source

Ficolins and the Fibrinogen-like Domain

Immunobiology, 1998
Ficolins are a group of proteins containing collagen-like and fibrinogen-like (FBG) sequences and they have a similar overall structure to C1q and the collectins. There are two types of ficolin in man: L-ficolin and M-ficolin. L-ficolin is synthesized in the liver and secreted into the plasma.
Lu, J., Le, Y.
openaire   +3 more sources

Associations of Ficolins With Hematological Malignancies in Patients Receiving High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantations

Frontiers in Immunology, 2020
A prospective study of 312 patients [194 with multiple myeloma (MM) and 118 with lymphomas (LYMPH)] receiving high-dose chemotherapy and autologous hematopoietic stem cell transplantation (auto-HSCT) was conducted.
Anna S. Świerzko, Mateusz Michalski, Anna Sokołowska, Mateusz Nowicki, Agnieszka Szala-Poździej, Łukasz Eppa, Iwona Mitrus, Anna Szmigielska-Kapłon, Małgorzata Sobczyk-Kruszelnicka, Katarzyna Michalak, Aleksandra Gołos, Agnieszka Wierzbowska, Sebastian Giebel, Krzysztof Jamroziak, Marek L. Kowalski, Olga Brzezińska, Olga Brzezińska, Steffen Thiel, Misao Matsushita, Jens C. Jensenius, Gabriela Gajek, Maciej Cedzyński   +21 more
doaj   +1 more source