Results 81 to 90 of about 1,942 (166)

Inefficient complement system clearance of Trypanosoma cruzi metacyclic trypomastigotes enables resistant strains to invade eukaryotic cells.

PLoS ONE, 2010
The complement system is the main arm of the vertebrate innate immune system against pathogen infection. For the protozoan Trypanosoma cruzi, the causative agent of Chagas disease, subverting the complement system and invading the host cells is crucial ...
Igor Cestari, Marcel I Ramirez
doaj   +1 more source

Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation

Immunobiology, 2005
The serum lectins mannose-binding lectin (MBL), L-ficolin, and H-ficolin are recognition molecules in the lectin complement pathway, which play an important role in innate immunity. To assess involvement of the lectin pathway in the clearance of apoptotic cells, we used flow cytometry to quantify binding of MBL, L-ficolin, and H-ficolin to apoptotic ...
Mikio, Kuraya, Zhenping, Ming, Xianzhou, Liu, Misao, Matsushita, Teizo, Fujita   +4 more
openaire   +2 more sources

Be on Target: Strategies of Targeting Alternative and Lectin Pathway Components in Complement-Mediated Diseases

Frontiers in Immunology, 2018
The complement system has moved into the focus of drug development efforts in the last decade, since its inappropriate or uncontrolled activation has been recognized in many diseases.
József Dobó, Andrea Kocsis, Péter Gál   +2 more
doaj   +1 more source

Ficolin-2 levels and FCN2 haplotypes influence hepatitis B infection outcome in Vietnamese patients.

PLoS ONE, 2011
Human Ficolin-2 (L-ficolins) encoded by FCN2 gene is a soluble serum protein that plays an important role in innate immunity and is mainly expressed in the liver.
Tong V Hoang, Nguyen L Toan, Le H Song, Eman Abou Ouf, C-Thomas Bock, Peter G Kremsner, Jürgen F J Kun, T P Velavan   +7 more
doaj   +1 more source

H-Ficolin

, 2013
H-ficolin is a serum lectin synthesized (as a ~34 kDa polypeptide) predominantly by the liver and lung tissues and is one of the soluble pattern recognition receptors of the innate immune system. It is structurally similar to L- and M- ficolins, but is different in its tissue expression and binding affinities to pathogenic ligands.
Chandrasekhar, Anjana, Dinasarapu, Ashok Reddy, Cedzynski, Maciej, Subramaniam, Shankar   +3 more
openaire   +1 more source

Molecular Pathway and Regulatory Mechanism of the Saponin Biosynthesis in Sea Cucumber Apostichopus japonicus

Marine Drugs
Sea cucumber Apostichopus japonicus is one of the few animals capable of synthesizing saponins, which are critical components of its nutritional quality and health-beneficial properties.
Pingzhe Jiang, Shan Gao, Yujun Liu, Zhong Chen, Liang Zhao, Zelong Zhao, Feifei Zhang, Yongjia Pan, Yao Xiao, Guohan Zhang, Jingwei Jiang, Zunchun Zhou   +11 more
doaj   +1 more source

L-Ficolin

, 2013
L-ficolin is a serum lectin synthesized (as a ~37 kDa polypeptide) predominantly by the liver, and is one of the key molecules of the innate immune system. It has an amino (N)-terminal cysteine-rich region, a middle stretch of a collagen-like sequence, and a fibrinogen-like domain in the carboxy (C)-terminus.
Chandrasekhar, Anjana, Dinasarapu, Ashok Reddy, Thiel, Steffen, Subramaniam, Shankar   +3 more
openaire   +1 more source

Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats.

PLoS ONE, 2015
The complement system has been increasingly recognized to play a pivotal role in a variety of inflammatory and autoimmune diseases. Consequently, therapeutic modulators of the classical, lectin and alternative pathways of the complement system are ...
Julia A Sharp, Pamela S Hair, Haree K Pallera, Parvathi S Kumar, Clifford T Mauriello, Julius O Nyalwidhe, Cody A Phelps, Dalnam Park, Nicole M Thielens, Stephen M Pascal, Waldon Chen, Diane M Duffy, Frank A Lattanzio, Kenji M Cunnion, Neel K Krishna   +14 more
doaj   +1 more source

Plenary Abstracts Session & Oral Presentations

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Advances in the lectin pathway in systemic lupus erythematosus: from clinical correlations and mechanisms to targeted interventions. [PDF]

Inflamm Res
Feng R, Zhang Y, Chen Q, Wang Y, Tian Y, Xia Y.   +5 more
europepmc   +1 more source