Results 71 to 80 of about 45,388 (244)

Biochemical data from the characterization of a new pathogenic mutation of human pyridoxine-5'-phosphate oxidase (PNPO) [PDF]

, 2017
PNPO deficiency is responsible of severe neonatal encephalopathy, responsive to pyridoxal-5’-phosphate (PLP) or pyridoxine. Recent studies widened the phenotype of this condition and detected new genetic variants on PNPO gene, whose pathogenetic role and
Carducci, Carla, Contestabile, Roberto, Di Salvo, Martino L., Guerrini, Renzo, Leuzzi, Vincenzo, Mastrangelo, Mario, Mei, Davide, Montomoli, Martino, Nogués, Isabel, Paiardini, Alessandro, Tolve, Manuela, Tramonti, Angela   +11 more
core   +2 more sources

Structure and Mechanism of PhdC, a Prenylated‐Flavin Maturase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prenylated flavin mononucleotide (prFMN) is a modified flavin cofactor required by the UbiD family of (de)carboxylase enzymes. While the reduced prFMNH2 form is produced by the flavin prenyltransferase UbiX, the corresponding two‐electron oxidized prFMNiminium form is required to support UbiD catalysis. Thus, oxidative maturation of prFMNH2 is
Dominic R. Whittall, Henry G. Box, Karl A. P. Payne, Stephen A. Marshall, David Leys   +4 more
wiley   +1 more source

The effect of the systemic inflammatory response on plasma vitamin 25 (OH) D concentrations adjusted for albumin [PDF]

, 2014
<b>Aim</b><p></p> To examine the relationship between plasma 25(OH)D, CRP and albumin concentrations in two patient cohorts.<p></p> <b>Methods</b><p></p> 5327 patients referred for ...
A Duncan, A Gray, A Gray, Andrew Duncan, AR Ghashut, AT Vasilaki, AT Vasilaki, AT Vasilaki, Brenda Smith, C Marsik, D Reid, Dinesh Talwar, Donald C. McMillan, EJC Oakes, JL Waldron, John Kinsella, JS Danik, L Zgaga, M Hewison, MM Levy, P Autier, P Galloway, P Goldwasser, Rawia A. Ghashut, RC Bone, S Hudson   +25 more
core   +2 more sources

Deciphering the properties and reaction mechanism of anhydromevalonate phosphate decarboxylase, a prenylated flavin mononucleotide‐dependent enzyme in the archaeal mevalonate pathway

The FEBS Journal, EarlyView.
Characterization of anhydromevalonate phosphate decarboxylase, the UbiD‐family decarboxylase involved in the archaeal mevalonate pathway, was conducted. The enzyme is responsible for the biosynthesis of isoprenoids, such as archaeal membrane lipids, respiratory quinones, and dolichols.
Rino Ishikawa, Natsumi Matsushima, Soma Ishimine, Honoka Nakamoto, Hajime Hayakawa, Yoko Yasuno, Tetsuro Shinada, Hiroshi Kawaide, Tomokazu Ito, Hisashi Hemmi   +9 more
wiley   +1 more source

Quantitive determination of flavin nucleotide using the bacterial bioluminescent reaction [PDF]

, 1969
Photometric method based on the use of bacterial luminiscent reaction quantitatively detects the presence of flavin compounds in all forms of life. Aqueous cellular dispersion of a biological sample with an aqueous perchloric acid ruptures the cells and ...
Chappelle, E. W., Picciolo, G. L.
core   +1 more source

Influence of riboflavin on the reduction of radionuclides by Shewanella oneidenis MR-1 [PDF]

, 2015
Uranium (as UO22+), technetium (as TcO4−) and neptunium (as NpO2+) are highly mobile radionuclides that can be reduced enzymatically by a range of anaerobic and facultatively anaerobic microorganisms, including Shewanella oneidensis MR-1, to poorly ...
Andrea Cherkouk, Athanasios Rizoulis, Balasubramanian, Bencheikh-Latmani, Bouhenni, Boukhalfa, Bretschger, De Luca, DiChristina, Francis R. Livens, Gareth T. W. Law, Hennig, Icopini, Joanna C. Renshaw, Johnson, Jonathan R. Lloyd, Katherine Morris, Katie Law, Kimber, Law, Law, Liu, Lloyd, Lloyd, Lloyd, Lovley, Lovley, Marsden, Marshall, Marshall, Marsili, McBeth, Morris, Myers, Myers, Newman, Newsome, Okamoto, Renshaw, Renshaw, Ross, Rossberg, Schwalb, Shi, Suzuki, Velasquez-Orta, von Canstein, Wall, Wildung, Zhang   +49 more
core   +2 more sources

The structure of Chlamydomonas LOV1 as revealed by time-resolved serial synchrotron crystallography

IUCrJ
The photo-reaction of the LOV1 domain of the Chlamydomonas reinhardtii phototropin is investigated by room-temperature time-resolved serial crystallography. A covalent adduct forms between the C4a atom of the central flavin-mononucleotide chromophore and
Marius Schmidt
doaj   +1 more source

Cofactor Trapping, a New Method To Produce Flavin Mononucleotide [PDF]

Applied and Environmental Microbiology, 2011
ABSTRACT We have purified flavin mononucleotide (FMN) from a flavoprotein-overexpressing Escherichia coli strain by cofactor trapping. This approach uses an overexpressed flavoprotein to trap FMN, which is thus removed from the cascade regulating FMN production in E. coli . This, in
Ulrich, Krauss, Vera, Svensson, Astrid, Wirtz, Esther, Knieps-Grünhagen, Karl-Erich, Jaeger   +4 more
openaire   +2 more sources

Defined Electrosynthetic Microbial Consortia Reveal Electron Transfer Modes Governing Acetate Production

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Spatially resolved Shewanella–acetogen interactions link DIET and MET pathways to acetate formation, offering a generalizable framework for designing structured, high‐efficiency microbial electrosynthesis systems. Abstract Precise manipulation of interspecies electron transfer (IET) is critical for advancing microbial electrosynthesis (MES) toward ...
Jing Zhang, He Liu, Qihao Cao, Chao Zhang, Min Zhang, Minhua Cui, Yan Zhang, Bo Fu, Hongbo Liu   +8 more
wiley   +1 more source

The 5′ Cap Epitranscriptome and Beyond: Natural and Engineered 5′ Cap Modifications for Optimizing mRNA Therapeutics and Functional Studies

ChemMedChem, Volume 21, Issue 2, January 2026.
5′ Cap modifications can be introduced via enzymes or chemical synthesis. Natural and non‐natural 5′ cap structures affect mRNA properties, including translation (T), stability (S), and/or immunogenicity (I). Eukaryotic mRNAs made by in vitro transcription have emerged as medical modalities for vaccination and protein replacement therapy. The 5′ cap is
Greta Charlotte Dahm, Melissa Pieper, Helena Schepers, Andrea Rentmeister   +3 more
wiley   +1 more source