Results 211 to 220 of about 7,338 (299)

Engineering Alloxazines by Boron Coordination and Click Chemistry toward Small-molecule Fluorescent Probes. [PDF]

open access: yesChemistry
Charpentier O   +5 more
europepmc   +1 more source

Knockout of TaCKX2.2 in Wheat Improved Grain Yield by Increasing Grain Number Per Spike and Grain Size Under Field Production Conditions

open access: yes
Plant, Cell &Environment, EarlyView.
Zhenzhen Zhu   +8 more
wiley   +1 more source

Discovery of a Potent and Selective MAO‐B Inhibitor From a Donepezil‐Linked Chalcone Library With Promising Antiparkinsonian Activity

open access: yesDrug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A focused library of 19 donepezil‐linked chalcones (DLCs) was efficiently synthesised through microwave‐assisted Claisen‐Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO‐A and MAO‐B).
Azize Kirac‐Aydin   +11 more
wiley   +1 more source

Miniaturized Droplet‐Based Adaptation of the Ames Test for High‐Throughput Mutagenicity Assessment

open access: yesJournal of Applied Toxicology, Volume 46, Issue 8, Page 2791-2802, August 2026.
ABSTRACT This work presents the first demonstration of a tube‐based droplet microfluidic implementation of the Ames test, bridging single‐droplet resolution with regulatory genotoxicity testing. The Ames test is a cornerstone assay for detecting mutagenicity, but conventional plate‐ and well‐based formats suffer from high reagent consumption, low ...
Jialan Cao   +3 more
wiley   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

open access: yesMedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang   +6 more
wiley   +1 more source

Identification of colorectal malignancies enabled by phasor-based autofluorescence lifetime macroimaging and ensemble learning. [PDF]

open access: yesBiophotonics Discov
Lagarto JL   +10 more
europepmc   +1 more source

The X‐Ray Crystal Structure of BorF, the Flavin Reductase Subunit of a Two‐Component Flavin‐Dependent Tryptophan Halogenase

open access: yesProteins: Structure, Function, and Bioinformatics, Volume 94, Issue 8, Page 1529-1540, August 2026.
ABSTRACT BorF is a short‐chain flavin reductase from a desert soil bacterium that uses NADH to reduce FAD to FADH2, which is used by the tryptophan‐6‐halogenase BorH to chlorinate tryptophan in the biosynthetic pathway of borregomycin A. The X‐ray crystal structure of BorF bound to FAD was solved to 2.37 Å by molecular replacement.
Zheng Ma   +3 more
wiley   +1 more source

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