Results 11 to 20 of about 151,012 (302)

Signaling through focal adhesion kinase [PDF]

Progress in Biophysics and Molecular Biology, 1999
Integrin receptor binding to extracellular matrix proteins generates intracellular signals via enhanced tyrosine phosphorylation events that are important for cell growth, survival, and migration.
Christof R. Hauck, David D. Schlaepfer, David J. Sieg   +2 more
core   +4 more sources

Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling [PDF]

iScience
Summary: Obesity is a significant public health concern associated with numerous health risks. Infections are a major complication of obesity, but the mechanisms driving increased infection risk remain unclear. Using a diet-induced obesity mouse model in
Laura Schwartz, Kristin Salamon, Aaron Simoni, Israel Cotzomi-Ortega, Yuriko Sanchez-Zamora, Sarah Linn-Peirano, Preeti John, Juan de Dios Ruiz-Rosado, Ashley R. Jackson, Xin Wang, John David Spencer   +10 more
doaj   +2 more sources

Mechanism of Focal Adhesion Kinase Mechanosensing.

PLoS Computational Biology, 2015
Mechanosensing at focal adhesions regulates vital cellular processes. Here, we present results from molecular dynamics (MD) and mechano-biochemical network simulations that suggest a direct role of Focal Adhesion Kinase (FAK) as a mechano-sensor. Tensile
Jing Zhou, Camilo Aponte-Santamaría, Sebastian Sturm, Jakob Tómas Bullerjahn, Agnieszka Bronowska, Frauke Gräter   +5 more
doaj   +6 more sources

Phospho-regulated tethering of focal adhesion kinase to vinculin links force transduction to focal adhesion signaling [PDF]

Cell Communication and Signaling
Focal Adhesion Kinase (FAK) is a key signaling molecule in focal adhesions (FAs) orchestrating the formation, maturation and turnover of the FA complex.
Karen Diaz-Palacios, Pilar López Navajas, Bárbara Rodrigo Martín, Ruth Matesanz, Juan R. Luque-Ortega, Asier Echarri, Daniel Lietha   +6 more
doaj   +3 more sources

The role of focal adhesion kinase in bladder cancer: translation from in vitro to ex vivo human urothelial carcinomas [PDF]

Radiology and Oncology
Focal adhesion kinase (FAK), a cytoplasmic tyrosine kinase, plays a crucial role in focal adhesion turnover by interfacing between the extracellular space, transmembrane integrins, and actin filaments.
Markovic Gaja, Resnik Natasa, Janev Aleksandar, Zupancic Dasa, Grubelnik Gasper, Debeljak Marusa, Cemazar Maja, Jesenko Tanja, Omerzel Masa, Smrkolj Tomaz, Kreft Mateja Erdani   +10 more
doaj   +2 more sources

Focal adhesion kinase: from biological functions to therapeutic strategies [PDF]

Experimental Hematology & Oncology, 2023
Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital participant in primary cellular functions, such as proliferation, survival, migration, and invasion. In addition, FAK regulates cancer stem cell activities and contributes
Ximin Tan, Yuheng Yan, Bin Song, Shuangli Zhu, Qi Mei, Kongming Wu   +5 more
doaj   +2 more sources

Acinar to β-like cell conversion through inhibition of focal adhesion kinase [PDF]

Nature Communications
Insufficient functional β-cell mass causes diabetes; however, an effective cell replacement therapy for curing diabetes is currently not available.
Shakti Dahiya, Mohamed Saleh, Uylissa A. Rodriguez, Dhivyaa Rajasundaram, Jorge R. Arbujas, Arian Hajihassani, Kaiyuan Yang, Anuradha Sehrawat, Ranjeet Kalsi, Shiho Yoshida, Krishna Prasadan, Heiko Lickert, Jing Hu, Jon D. Piganelli, George K. Gittes, Farzad Esni   +15 more
doaj   +2 more sources

αV-Integrins Are Required for Mechanotransduction in MDCK Epithelial Cells [PDF]

, 2013
The properties of epithelial cells within tissues are regulated by their immediate microenvironment, which consists of neighboring cells and the extracellular matrix (ECM).
Engler, Adam J., Friedrichs, Jens, Manninen, Aki, Matlin, Karl S., Moyano, Jose V., Muller, Daniel J., Myllymäki, Satu M., Strohmeyer, Nico, Teräväinen, Terhi P., Wu, Chuanyue   +9 more
core   +10 more sources

Activation of Rho-kinase and focal adhesion kinase regulates the organization of stress fibers and focal adhesions in the central part of fibroblasts [PDF]

PeerJ, 2017
Specific regulation and activation of focal adhesion kinase (FAK) are thought to be important for focal adhesion formation, and activation of Rho-kinase has been suggested to play a role in determining the effects of FAK on the formation of stress fibers
Kazuo Katoh
doaj   +2 more sources

Cas phosphorylation regulates focal adhesion assembly

eLife, 2023
Integrin-mediated cell attachment rapidly induces tyrosine kinase signaling. Despite years of research, the role of this signaling in integrin activation and focal adhesion assembly is unclear.
Saurav Kumar, Amanda Stainer, Julien Dubrulle, Christopher Simpkins, Jonathan A Cooper   +4 more
doaj   +1 more source