Results 31 to 40 of about 151,012 (302)

Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo. [PDF]

, 1995
The NPXY sequence is highly conserved among integrin beta subunit cytoplasmic tails, suggesting that it plays a fundamental role in regulating integrin-mediated function.
Brooks, PC, Cheresh, DA, Damsky, C, Deming, SL, Filardo, EJ   +4 more
core   +2 more sources

PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility

Cells, 2020
Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associated with poor prognosis of cancer patients.
Hsin-Wei Jen, De-Leung Gu, Yaw-Dong Lang, Yuh-Shan Jou   +3 more
doaj   +1 more source

Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. [PDF]

, 2014
To enable new blood vessel growth, endothelial cells (ECs) express neuropilin 1 (NRP1), and NRP1 associates with the receptor tyrosine kinase VEGFR2 after binding the vascular endothelial growth factor A (VEGF) to enhance arteriogenesis.
Alessandro Fantin, Anastasia Lampropoulou, Anissa Chikh, Anselmi, Ballmer-Hofer, Baruzzi, Birukova, Buchdunger, Campochiaro, Carmeliet, Casanovas, Chen, Chen, Chislock, Cho, Choi, Christiana Ruhrberg, Clark, Claudio Raimondi, Colicelli, Connor, Cui, Cujec, Dejana, Druker, Fantin, Fantin, Fantin, Fantin, Foxton, Fukasawa, Gerhardt, Gerhardt, Herzog, Kawamura, Kawasaki, Kim, Kitsukawa, Koch, Lanahan, Lanahan, Laura Denti, Lewis, Lewis, Mamluk, Murga, Nishijima, Pan, Pan, Parsons, Pasapera, Phng, Raimondi, Ren, Robinson, Roig, Rosenfeld, Ruhrberg, Ruhrberg, Saint-Geniez, Salikhova, Shimizu, Shojaei, Smith, Soker, Sottile, Stenzel, Tvorogov, Uemura, Valdembri, Wang, Welti, Yaqoob, Zaidel-Bar, Zhuang   +74 more
core   +4 more sources

Focal adhesion kinase and tumour angiogenesis [PDF]

The Journal of Pathology, 2011
AbstractAngiogenesis, the formation of new blood vessels from pre‐existing ones, is essential for tumour development. It is initiated and regulated by growth factors via their surface receptors, which activate several intracellular signalling pathways in endothelial cells. Cell adhesion molecules, such as integrins, also regulate angiogenesis.
Tanguy, Lechertier, Kairbaan, Hodivala-Dilke   +1 more
openaire   +2 more sources

Targeting Focal Adhesion Kinase in Neuroblastoma [PDF]

Anti-Cancer Agents in Medicinal Chemistry, 2010
Neuroblastoma is the most common extracranial solid tumor encountered in children, and continues to carry a dismal prognosis. Focal adhesion kinase (FAK) has been shown to be upregulated in a number of human tumors and is related to tumor virulence and patient prognosis.
Lauren, Gillory, Elizabeth A, Beierle
openaire   +2 more sources

Requirement of focal adhesion kinase in branching tubulogenesis

Journal of Biomedical Science, 2009
We previously demonstrated that α3β1 integrins are essential to hepatocyte growth factor (HGF)-independent branching tubulogenesis in Mardin-Darby Canine Kidney (MDCK) cells.
Wei Wei-Chun, Kopec Anna K, Tang Ming-Jer   +2 more
doaj   +1 more source

Focal adhesion kinase inhibitors, a heavy punch to cancer

Discover Oncology, 2021
Kinases are the ideal druggable targets for diseases and especially were highlighted on cancer therapy. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and its aberrant signaling extensively implicates in the progression of most cancer ...
Yueling Wu, Ning Li, Chengfeng Ye, Xingmei Jiang, Hui Luo, Baoyuan Zhang, Ying Zhang, Qingyu Zhang   +7 more
doaj   +1 more source

Protein Kinase C Activation Stimulates Mesenchymal Stem Cell Adhesion through Activation of Focal Adhesion Kinase

Cell Transplantation, 2013
Emerging evidence suggests that cell therapy with mesenchymal stem cells (MSCs) has beneficial effects on the injured heart. However, the decreased survival and/or adhesion of MSCs under ischemic conditions limits the application of cell transplantation ...
Byeong-Wook Song, Woochul Chang, Bum-Kee Hong, Il-Kwon Kim, Min-Ji Cha, Soyeon Lim, Eun Ju Choi, Onju Ham, Se-Yeon Lee, Chang Youn Lee, Jun-Hee Park, Eunmi Choi, Heesang Song, Yangsoo Jang, Ki-Chul Hwang Ph.D.   +14 more
doaj   +1 more source

Abnormal Endothelial Gene Expression Associated With Early Coronary Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background We examined feasibility of a unique approach towards gaining insight into heritable risk for early atherosclerosis: surveying gene expression by endothelial cells from living subjects. Methods and Results Subjects aged
Robert P. Hebbel, Peng Wei, Liming Milbauer, Michel T. Corban, Anna Solovey, James Kiley, Jack Pattee, Lilach O. Lerman, Wei Pan, Amir Lerman   +9 more
doaj   +1 more source

Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. [PDF]

, 2017
Neurite initiation is the first step in neuronal development and occurs spontaneously in soft tissue environments. Although the mechanisms regulating the morphology of migratory cells on rigid substrates in cell culture are widely known, how soft ...
Chang, Ting-Ya, Chang, Ya-Chu, Chen, Chen, Cheng, Pei-Lin, Guo, Chin-Lin, Lee, Min, Lu, Chi-Huan, Lu, Shao-Tzu, Wang, Aijun, Wang, De-Yao   +9 more
core   +2 more sources