Redox regulation of focal adhesions [PDF]
Redox BiologyFocal adhesions (FAs), multi-protein complexes that link the extracellular matrix to the intracellular cytoskeleton, are key mediators of cell adhesion, migration, and proliferation.
Gianmarco Matrullo +2 more
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Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions [PDF]
eLife, 2016 The cross-talk between dynamic microtubules and integrin-based adhesions to the extracellular matrix plays a crucial role in cell polarity and migration.
Benjamin P Bouchet +9 more
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Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility [PDF]
BMC Cell Biology, 2011 Background Cell migration plays an important role in many physiological and pathological processes, including immune cell chemotaxis and cancer metastasis.
Wang Wenqi, Liu Yang, Liao Kan
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A Layered View on Focal Adhesions [PDF]
Biology, 2021 The cytoskeleton provides structure to cells and supports intracellular transport. Actin fibres are crucial to both functions. Focal Adhesions (FAs) are large macromolecular multiprotein assemblies at the ends of specialised actin fibres linking these to
Karin Legerstee, Adriaan B. Houtsmuller
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Endothelial Focal Adhesions Are Functional Obstacles for Leukocytes During Basolateral Crawling
Frontiers in Immunology, 2021 An inflammatory response requires leukocytes to migrate from the circulation across the vascular lining into the tissue to clear the invading pathogen.
Janine J. G. Arts +13 more
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A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes
Biophysical Reports, 2021 Mechanotransduction at focal adhesion complexes is key for various cellular events. Theoretical analyses were performed to predict a potential role of lipid membranes in modulating mechanotransduction at focal adhesions.
Jichul Kim
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Activation of Rho-kinase and focal adhesion kinase regulates the organization of stress fibers and focal adhesions in the central part of fibroblasts [PDF]
PeerJ, 2017 Specific regulation and activation of focal adhesion kinase (FAK) are thought to be important for focal adhesion formation, and activation of Rho-kinase has been suggested to play a role in determining the effects of FAK on the formation of stress fibers
Kazuo Katoh
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Focal adhesions as mechanosensors: the two-spring model [PDF]
, 2004 Adhesion-dependent cells actively sense the mechanical properties of their environment through mechanotransductory processes at focal adhesions, which are integrin-based contacts connecting the extracellular matrix to the cytoskeleton.
Schwarz, Ulrich S. +2 more
core +3 more sources
Nudel and FAK as antagonizing strength modulators of nascent adhesions through paxillin. [PDF]
PLoS Biology, 2009 Adhesion and detachment are coordinated critical steps during cell migration. Conceptually, efficient migration requires both effective stabilization of membrane protrusions at the leading edge via nascent adhesions and their successful persistence ...
Yongli Shan +7 more
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Bioactive Materials, 2022 Focal adhesion complexes function as the mediators of cell-extracellular matrix interactions to sense and transmit the extracellular signals. Previous studies have demonstrated that cardiomyocyte focal adhesions can be modulated by surface topographic ...
Huaiyu Shi +9 more
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