Results 11 to 20 of about 12,893 (183)

Maternal Serum Activin A, Inhibin A and Follistatin-Related Proteins across Preeclampsia: Insights into Their Role in Pathogenesis and Prediction. [PDF]

J Mother Child, 2023
Within the endocrine-paracrine signalling network at the maternal-foetal interface, the activin-inhibin-follistatin system modulates extravillous trophoblast invasion, suggesting a potential role in preeclampsia pathogenesis. This study aimed to compile the evidence published in the last decade regarding the variation in maternal serum activins ...
Barrero JA, Villamil-Camargo LM, Imaz JN, Arciniegas-Villa K, Rubio-Romero JA.   +4 more
europepmc   +3 more sources

Follistatin-Related Protein and Follistatin Differentially Neutralize Endogenous vs. Exogenous Activin [PDF]

Endocrinology, 2002
Follistatin-related protein (FSRP) is a new addition to the expanding follistatin (FS)-related gene family whose members contain at least one conserved 10-cysteine follistatin domain. In contrast to other members of this family, FSRP and follistatin also share a common exon/intron domain structure, substantial primary sequence homology, and an ability ...
Yisrael, Sidis, Drew V, Tortoriello, William E, Holmes, Yang, Pan, Henry T, Keutmann, Alan L, Schneyer   +5 more
openaire   +3 more sources

Human Follistatin-Related Protein: A Structural Homologue of Follistatin with Nuclear Localization [PDF]

Endocrinology, 2001
Follistatin-related protein is a recently discovered glycoprotein that is highly homologous in both primary sequence and exon/intron domain structure to the activin-binding protein, follistatin. We explored their potential for functional redundancy by investigating the relative affinities and kinetics of their interactions with activin, bone ...
D V, Tortoriello, Y, Sidis, D A, Holtzman, W E, Holmes, A L, Schneyer   +4 more
openaire   +3 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Prediabetes Associates With Musculoskeletal Alterations Independent of Total Body Adiposity. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Excess adiposity is a major risk factor for insulin resistance, prediabetes, and Type 2 diabetes and increases the risk for sarcopenia and osteosarcopenia later in life. It has been proposed that altered metabolic function and musculoskeletal status in people with obesity are directly linked, presumably because they share common ...
Fappi A, Holmes CJ, Cao C, Shabrish V, Aher AP, Shen K, Commean PK, Towler DA, Reeds DN, Meyer GA, Mittendorfer B.   +10 more
europepmc   +2 more sources

miR-200c-3p Regulates Epitelial-to-Mesenchymal Transition in Epicardial Mesothelial Cells by Targeting Epicardial Follistatin-Related Protein 1 [PDF]

International Journal of Molecular Sciences, 2021
Recent findings suggest that epithelial to mesenchymal transition (EMT), a key step during heart development, is involved in cardiac tissue repair following myocardial infarction (MI). MicroRNAs (miRNAs) act as key regulators in EMT processes; however, the mechanisms by which miRNAs target epicardial EMT remain largely unknown.
Elena Pontemezzo, Eleonora Foglio, Enza Vernucci, Alessandra Magenta, Marco D’Agostino, Sara Sileno, Elena Astanina, Federico Bussolino, Laura Pellegrini, Antonia Germani, Matteo Antonio Russo, Federica Limana   +11 more
openaire   +3 more sources

Role of Peptides in Skeletal Muscle Wasting: A Scoping Review. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Systemic muscle wasting is a prevalent condition that predicts adverse health outcomes in aging and disease. Despite its clinical relevance, the development of predictive biomarkers and effective pharmacological therapies remains limited. Peptides have recently gained attention for their diverse bioactive functions, positioning them
Naumovski P, De Spiegeleer B, Wakjira A, Van De Wiele C, Mouly V, Goljanek-Whysall K, da Costa KS, de Oliveira ECL, Wynendaele E, De Spiegeleer A.   +9 more
europepmc   +2 more sources

Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis

Scientific Reports, 2021
Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis, but analyses must account for disease heterogeneity.
Ellen F. Mosleth, Christian Alexander Vedeler, Kristian Hovde Liland, Anette McLeod, Gerd Haga Bringeland, Liesbeth Kroondijk, Frode Steingrimsen Berven, Artem Lysenko, Christopher J. Rawlings, Karim El-Hajj Eid, Jill Anette Opsahl, Bjørn Tore Gjertsen, Kjell-Morten Myhr, Sonia Gavasso   +13 more
doaj   +1 more source

Integrating plasma proteomes with genome-wide association data for causal protein identification in multiple myeloma

BMC Medicine, 2023
Background Multiple myeloma (MM) is a severely debilitating and fatal B-cell neoplastic disease. The discovery of disease-associated proteins with causal genetic evidence offers a chance to uncover novel therapeutic targets.
Qiangsheng Wang, Qiqin Shi, Zhenqian Wang, Jiawen Lu, Jian Hou   +4 more
doaj   +1 more source

Follistatin as potential therapeutic target in prostate cancer [PDF]

, 2013
Follistatin is a single-chain glycosylated protein whose primary function consists in binding and neutralizing some members of the transforming growth factor-β superfamily such as activin and bone morphogenic proteins.
CRESCIMANNO, Marilena, DI MAJO, Danila, FLANDINA, Carla, GIAMMANCO, Marco, LA GUARDIA, Maurizio, LETO, Gaetano, Sepporta, MV, TUMMINELLO, Francesca Maria   +7 more
core   +1 more source