Results 61 to 70 of about 120,643 (297)
Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis
Advanced Science, EarlyView.Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang +16 more
wiley +1 more source
Direct and dynamic detection of HIV-1 in living cells. [PDF]
, 2012 In basic and applied HIV research, reliable detection of viral components is crucial to monitor progression of infection. While it is routine to detect structural viral proteins in vitro for diagnostic purposes, it previously remained impossible to ...
Helma, Jonas +7 more
core +3 more sources
Quantifying transcriptional dynamics by TF-FRAP [PDF]
, 2020 Transcription factors are DNA binding proteins, upon binding, they can regulate the expression of their target genes. SOX9 and RUNX2 are the master transcription factors of cartilage and bone development, respectively. They play crucial role in the progression of osteoarthritis (OA).
openaire +1 more source
Advanced Science, EarlyView.NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang +8 more
wiley +1 more source
Betalains and phenolic compounds of leaves and stems of Alternanthera brasiliana and Alternanthera tenella [PDF]
, 2018 Betacyanins and phenolic compounds from acetonitrile:acidified water extracts of Alternanthera brasiliana and Alternanthera tenella were characterized and quantified using a high-performance liquid chromatography system coupled with diode array and ...
Alvarez, I. +5 more
core +1 more source
Advanced Science, EarlyView.This study shows that BLADE‐ON‐PETIOLE (BOP) proteins regulate floral abscission and senescence in tomato by interacting with TFAM1 to form transcriptional condensates controlling the ARABIDOPSIS THALIANA HOMEOBOX GENE 1 (ATH1)‐mediated abscission pathway.
Nan Xiao +7 more
wiley +1 more source
Effect of heat treatment on phenolic content and antioxidant activity of peanut (Arachis hypogaea L.) extracts [PDF]
مجلة جامعة الانبار للعلوم الصرفةPeanuts are rich in various bioactive compounds, including total phenolics and total flavonoids. The aim of this study is to evaluate the effects of heating on total phenolic content, total flavonoid content, and antioxidant activity in peanut (Arachis ...
Eman Mohamed +3 more
doaj +1 more source
Polycomb group protein complexes exchange rapidly in living Drosophila [PDF]
, 2005 Fluorescence recovery after photobleaching (FRAP) microscopy was used to determine the kinetic properties of Polycomb group (PcG) proteins in whole living Drosophila organisms (embryos) and tissues (wing imaginal discs and salivary glands). PcG genes are
Arndt-Jovin, D. +2 more
core
Plasma antioxidants from chocolate [PDF]
, 2003 There is some speculation that dietary flavonoids from chocolate, in particular (-)epicatechin, may promote cardiovascular health as a result of direct antioxidant effects or through antithrombotic mechanisms. Here we show that consumption of plain, dark
AJ Charlton +12 more
core +1 more source
Advanced Science, EarlyView.Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo +7 more
wiley +1 more source