FUT11-Driven fucosylation coordinates K63 ubiquitination of keratin 17 to sustain psoriatic keratinocytes hyperproliferation [PDF]
Cell Communication and SignalingBackground The pathogenesis of psoriasis is characterized by dysregulated post-translational modifications, with particular emphasis on fucosylation—a glycosylation process mediated by fucosyltransferases (FUTs).
Xia Li +8 more
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Fucosylated Proteome Profiling Identifies a Fucosylated, Non-Ribosomal, Stress-Responsive Species of Ribosomal Protein S3 [PDF]
Cells, 2021 Alterations in genes encoding for proteins that control fucosylation are known to play causative roles in several developmental disorders, such as Dowling-Degos disease 2 and congenital disorder of glycosylation type IIc (CDGIIc).
Gregory Watson +11 more
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FUT3 mediated GRP78 fucosylation promotes colorectal cancer survival and proliferation under glucose restriction via PERK/ATF4/STC2 axis [PDF]
npj Precision OncologyTumor competition for nutrients within the microenvironment triggers stress responses to adapt to adverse conditions; however, the mechanism by which a glucose-depleted environment influences tumor fucosylation to promote endoplasmic reticulum (ER ...
Kaiwen Qin +15 more
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Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis [PDF]
Advanced ScienceThe growing incidence of inflammatory bowel diseases, including colitis and Crohn's disease, poses a critical challenge for global healthcare. Current development of α1,2‐fucosylation‐enhancing strategies shows significant potential as a colitis ...
Ye Yao +10 more
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Advances and challenges in plant N-glycoengineering: when fucosylation matters [PDF]
Frontiers in Plant SciencePlant-based expression systems have emerged as promising platforms to produce recombinant glycoproteins. Transient recombinant protein production is a promising alternative to stable transgenic systems, particularly for emergency situations in which ...
Kavya Gauba +2 more
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FUT1-mediated terminal fucosylation acts as a new target to attenuate renal fibrosis
Molecular Medicine, 2023 Backgrounds Renal fibrosis is a common pathologic process of most chronic kidney diseases (CKDs), becoming one of the major public health problems worldwide.
Jialiang Luo +9 more
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Arthritis Research & Therapy, 2022 Background Osteoarthritis (OA) is the most common form of arthritis and is characterized by the degradation of articular cartilage and inflammation of the synovial membrane.
Hanjie Yu +11 more
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Linkage specific fucosylation of alpha-1-antitrypsin in liver cirrhosis and cancer patients: implications for a biomarker of hepatocellular carcinoma. [PDF]
PLoS ONE, 2010 We previously reported increased levels of protein-linked fucosylation with the development of liver cancer and identified many of the proteins containing the altered glycan structures. One such protein is alpha-1-antitrypsin (A1AT).
Mary Ann Comunale +7 more
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Multi-targeted therapy resistance via drug-induced secretome fucosylation
eLife, 2023 Cancer secretome is a reservoir for aberrant glycosylation. How therapies alter this post- translational cancer hallmark and the consequences thereof remain elusive.
Mark Borris D Aldonza +19 more
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Frontiers in Microbiology, 2020 The fucosylated carbohydrate moieties on intestinal epithelial cells (IECs) are involved in the creation of an environmental niche for commensal and pathogenic bacteria. Core fucosylation catalyzed by fucosyltransferase 8 (Fut8) is the major fucosylation
Sijia Hao +8 more
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