Fentanyl Promotes Breast Cancer Cell Stemness and Epithelial-Mesenchymal Transition by Upregulating α1, 6-Fucosylation via Wnt/β-Catenin Signaling Pathway [PDF]
Frontiers in Physiology, 2017 Cancer pain is a common and severe complication of human breast cancer, and relieving pain is fundamental strategy in the treatment. Fentanyl, as an opioid analgesic, is widely used in breast cancer patients. However, little is known about its effects on
Hong-Fang Yang +7 more
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FUT11-Driven fucosylation coordinates K63 ubiquitination of keratin 17 to sustain psoriatic keratinocytes hyperproliferation [PDF]
Cell Communication and SignalingBackground The pathogenesis of psoriasis is characterized by dysregulated post-translational modifications, with particular emphasis on fucosylation—a glycosylation process mediated by fucosyltransferases (FUTs).
Xia Li +8 more
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Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis [PDF]
Advanced ScienceThe growing incidence of inflammatory bowel diseases, including colitis and Crohn's disease, poses a critical challenge for global healthcare. Current development of α1,2‐fucosylation‐enhancing strategies shows significant potential as a colitis ...
Ye Yao +10 more
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FUT3 mediated GRP78 fucosylation promotes colorectal cancer survival and proliferation under glucose restriction via PERK/ATF4/STC2 axis [PDF]
npj Precision OncologyTumor competition for nutrients within the microenvironment triggers stress responses to adapt to adverse conditions; however, the mechanism by which a glucose-depleted environment influences tumor fucosylation to promote endoplasmic reticulum (ER ...
Kaiwen Qin +15 more
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ABO phenotype protected reproduction as it is based on fucosylations.
, 2016 Peter Arend
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Cells, 2021 Alterations in genes encoding for proteins that control fucosylation are known to play causative roles in several developmental disorders, such as Dowling-Degos disease 2 and congenital disorder of glycosylation type IIc (CDGIIc).
Gregory Watson +11 more
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FUT1-mediated terminal fucosylation acts as a new target to attenuate renal fibrosis
Molecular Medicine, 2023 Backgrounds Renal fibrosis is a common pathologic process of most chronic kidney diseases (CKDs), becoming one of the major public health problems worldwide.
Jialiang Luo +9 more
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Arthritis Research & Therapy, 2022 Background Osteoarthritis (OA) is the most common form of arthritis and is characterized by the degradation of articular cartilage and inflammation of the synovial membrane.
Hanjie Yu +11 more
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Multi-targeted therapy resistance via drug-induced secretome fucosylation
eLife, 2023 Cancer secretome is a reservoir for aberrant glycosylation. How therapies alter this post- translational cancer hallmark and the consequences thereof remain elusive.
Mark Borris D Aldonza +19 more
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Mutation of GDP-mannose-4,6-dehydratase in colorectal cancer metastasis. [PDF]
PLoS ONE, 2013 Fucosylation is a crucial oligosaccharide modification in cancer. The known function of fucosylation in cancer is to mediate metastasis through selectin ligand-dependent processes.
Kotarosumitomo Nakayama +6 more
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