Results 11 to 20 of about 9,249 (168)
Fluorinated rhamnosides inhibit cellular fucosylation [PDF]
Nature Communications, 2021 Aberrant expression of fucosylated glycans has been linked to several disease states. Control of fucose expression on live cells is needed to aid research and therapy development.
Johan F. A. Pijnenborg +9 more
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Fucosylation in Urological Cancers [PDF]
International Journal of Molecular Sciences, 2021 Fucosylation is an oligosaccharide modification that plays an important role in immune response and malignancy, and specific fucosyltransferases (FUTs) catalyze the three types of fucosylations: core-type, Lewis type, and H type. FUTs regulate cancer proliferation, invasiveness, and resistance to chemotherapy by modifying the glycosylation of signaling
Kazutoshi Fujita +6 more
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Mutation of GDP-mannose-4,6-dehydratase in colorectal cancer metastasis. [PDF]
PLoS ONE, 2013 Fucosylation is a crucial oligosaccharide modification in cancer. The known function of fucosylation in cancer is to mediate metastasis through selectin ligand-dependent processes.
Kotarosumitomo Nakayama +6 more
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Core Fucosylation Regulates the Function of Pre-BCR, BCR and IgG in Humoral Immunity
Frontiers in Immunology, 2022 Most of the membrane molecules involved in immune response are glycosylated. N-glycans linked to asparagine (Asn) of immune molecules contribute to the protein conformation, surface expression, stability, and antigenicity.
Yuhan Sun +4 more
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Cells, 2023 Various tumors rely on post-translational modifications (PTMs) to promote invasiveness and angiogenesis and to reprogram cellular energetics to abate anti-cancer immunity.
Gabriele Antonarelli +6 more
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Semisynthetic Isomers of Fucosylated Chondroitin Sulfate Polysaccharides with Fucosyl Branches at a Non-Natural Site [PDF]
Biomacromolecules, 2021 The several interesting activities detected for fucosylated chondroitin sulfate (fCS) have fueled in the last years several efforts toward the obtainment of fCS oligosaccharides and low molecular weight (LMW) polysaccharides with a well-defined structure, in order to avoid the problems associated with the potential employment of native, sea cucumber ...
Vessella, Giulia +7 more
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Cell Death and Disease, 2021 Vaginal dysbiosis often occurs in patients with cervical cancer. The fucosylation of mucosal epithelial cells is closely related to microbial colonization, and play an important role in protecting the vaginal mucosal epithelial cells. However, no reports
Qingjie Fan +10 more
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Fucosylated glycoproteins and fucosylated glycolipids play opposing roles in cholera intoxication
, 2023 SUMMARYCholera toxin (CT) is the etiological agent of cholera. Here we report that multiple classes of fucosylated glycoconjugates function in CT binding and intoxication of intestinal epithelial cells. In Colo205 cells, knockout of B3GNT5, the enzyme required for synthesis of lacto- and neolacto-series glycosphingolipids (GSLs), reduces CT binding but
Atossa C. Ghorashi +9 more
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Fucosylation in prokaryotes and eukaryotes [PDF]
Glycobiology, 2006 Fucosylated carbohydrate structures are involved in a variety of biological and pathological processes in eukaryotic organisms including tissue development, angiogenesis, fertilization, cell adhesion, inflammation, and tumor metastasis. In contrast, fucosylation appears less common in prokaryotic organisms and has been suggested to be involved in ...
Bing, Ma +2 more
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Journal of Translational Medicine, 2023 Background Our previous study showed that fucosyltransferase 2 (Fut2) deficiency is closely related to colitis. Colitis increases the risk for the development of colorectal cancer (CRC). This study aimed to investigate the effect and underlying mechanism
Weijun Wang +8 more
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