Results 31 to 40 of about 9,249 (168)

Loss of core fucosylation suppressed the humoral immune response in Salmonella typhimurium infected mice

Journal of Microbiology, Immunology and Infection, 2021
Background: The humoral immune response is pivotal to protect the host from Salmonella typhimurium (S. typhimurium) infection. Previously, we found that core fucosylation catalyzed by core fucosyltransferase (Fut8) could regulate the immune responses ...
Danish Zahid, Nianzhu Zhang, Hui Fang, Jianguo Gu, Ming Li, Wenzhe Li   +5 more
doaj   +1 more source

Fucosyl gangliosides of PC12 pheochromocytoma cells [PDF]

FEBS Letters, 1984
Three monosialogangliosides are highly labeled when PC12 pheochromocytoma cells are cultured in the presence of L‐[3H] fucose, and two additional monosialogangliosides are labeled to a lesser extent. In contrast, neither of the two disialogangliosides of PC12 cells contains fucose residues.
Margolis, R.U., Mazzulla, M., Greene, L.A., Margolis, R.K.   +3 more
openaire   +2 more sources

Fucosylation in digestive inflammatory diseases and cancers: From mechanical studies to clinical translation

Genes and Diseases
Fucosylation is a post-translational modification that attaches fucose to glycoproteins or glycolipids, thereby influencing their biological functions. Consequently, fucosylation proves indispensable for many biological processes, such as ligand–receptor
Caihan Duan, Junhao Wu, Zhe Wang, Xiaohua Hou, Chaoqun Han   +4 more
doaj   +1 more source

Impact of IgG1 N-glycosylation on their interaction with Fc gamma receptors

Current Research in Immunology, 2020
The effector functions of the IgGs are modulated by the N-glycosylation of their Fc region. Particularly, the absence of core fucosylation is known to increase the affinity of IgG1s for the Fcγ receptor IIIa expressed by immune cells, in turn translating
Florian Cambay, Céline Raymond, Denis Brochu, Michel Gilbert, The Minh Tu, Christiane Cantin, Anne Lenferink, Maxime Grail, Olivier Henry, Gregory De Crescenzo, Yves Durocher   +10 more
doaj   +1 more source

Abnormal B cell glycosylation in autoimmunity: A new potential treatment strategy

Frontiers in Immunology, 2022
Systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS) are two autoimmune diseases characterised by the production of pathogenic autoreactive antibodies. Their aetiology is poorly understood. Nevertheless, they have been shown to involve
Marie Morel, Pierre Pochard, Pierre Pochard, Wiam Echchih, Maryvonne Dueymes, Maryvonne Dueymes, Cristina Bagacean, Cristina Bagacean, Sandrine Jousse-Joulin, Sandrine Jousse-Joulin, Valérie Devauchelle-Pensec, Valérie Devauchelle-Pensec, Divi Cornec, Divi Cornec, Christophe Jamin, Christophe Jamin, Jacques-Olivier Pers, Jacques-Olivier Pers, Anne Bordron   +18 more
doaj   +1 more source

IgG Fucosylation: An Emerging Key Player in the Treatment of Severe COVID-19

Engineering
Protein glycosylation is one of the most vital modifications. Understanding the role of protein glycosylation in coronavirus disease 2019 (COVID-19) is the key in elucidating its pathogenesis and developing therapeutic strategies.
Caiping Zhao, Jingrong Wang, Yuan Liu, Baoling Shang, Danna Lin, Yao Xiao, Hong Ren, Yue Li, Wen Rui, Xu Zou, Hudan Pan, Liang Liu   +11 more
doaj   +1 more source

NF-κB Signaling Is Regulated by Fucosylation in Metastatic Breast Cancer Cells

Biomedicines, 2020
A growing body of evidence indicates that the levels of fucosylation correlate with breast cancer progression and contribute to metastatic disease. However, very little is known about the signaling and functional outcomes that are driven by fucosylation.
Emma H. Doud, Trupti Shetty, Melissa Abt, Amber L. Mosley, Timothy W. Corson, Anand Mehta, Elizabeth S. Yeh   +6 more
doaj   +1 more source

Effects of microRNAs on fucosyltransferase 8 (FUT8) expression in hepatocarcinoma cells. [PDF]

PLoS ONE, 2013
Fucosyltransferase 8 (FUT8) catalyzes the transfer of α1,6-linked fucose to the first N-acetylglucosamine in N-linked glycans (core fucosylation). Increased core fucosylation has been reported during hepatocarcinogenesis, in both cell-associated and ...
Cinzia Bernardi, Ugo Soffientini, Francesco Piacente, Michela G Tonetti   +3 more
doaj   +1 more source

The Role of Glycosylation in Melanoma Progression

Cells, 2021
Malignant melanoma is the most aggressive form of skin cancer, which originates from the malignant transformation of melanocytes, the melanin-producing cells of the skin.
Chiara De Vellis, Silvia Pietrobono, Barbara Stecca   +2 more
doaj   +1 more source

Characterization of core fucosylation via sequential enzymatic treatments of intact glycopeptides and mass spectrometry analysis

Nature Communications, 2022
Core fucosylation of N-linked glycoproteins has been linked to physiological and pathological processes. Here, the authors develop a mass spectrometry-based method that utilizes Endo F3 followed by PNGase F treatment to quantify site-specific ...
Liwei Cao, T. Mamie Lih, Yingwei Hu, Michael Schnaubelt, Shao-Yung Chen, Yangying Zhou, Chuanyu Guo, Mingming Dong, Weiming Yang, Rodrigo Vargas Eguez, Lijun Chen, David J. Clark, Akrit Sodhi, Qing Kay Li, Hui Zhang   +14 more
doaj   +1 more source