Results 41 to 50 of about 17,469 (199)

p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death [PDF]

, 2016
p53 is a central factor in tumor suppression as exemplified by its frequent loss in human cancer. p53 exerts its tumor suppressive effects in multiple ways, but the ability to invoke the eradication of damaged cells by programmed cell death is considered
Baudot, Alice D., Crighton, Diane, O'Prey, Jim, Ryan, Kevin M., Sierra Gonzalez, Pablo, Somers, Joanna   +5 more
core   +2 more sources

Effects of microRNAs on fucosyltransferase 8 (FUT8) expression in hepatocarcinoma cells. [PDF]

PLoS ONE, 2013
Fucosyltransferase 8 (FUT8) catalyzes the transfer of α1,6-linked fucose to the first N-acetylglucosamine in N-linked glycans (core fucosylation). Increased core fucosylation has been reported during hepatocarcinogenesis, in both cell-associated and ...
Cinzia Bernardi, Ugo Soffientini, Francesco Piacente, Michela G Tonetti   +3 more
doaj   +1 more source

2-Fluorofucose Attenuates Hydrogen Peroxide-Induced Oxidative Stress in HepG2 Cells via Nrf2/keap1 and NF-κB Signaling Pathways

Life, 2022
Fucosylation is one of the most important glycan terminal modifications that affects multiple biological activities of proteins. 2-Fluorofucose (2FF), its specific inhibitor, has recently been reported to reveal numerous biological effects by blocking ...
Mengjue Tu, Xingshuo Fan, Jianan Shi, Shengnan Jing, Xiaole Xu, Yuqin Wang   +5 more
doaj   +1 more source

Salmonella Degrades the Host Glycocalyx Leading to Altered Infection and Glycan Remodeling. [PDF]

, 2016
Complex glycans cover the gut epithelial surface to protect the cell from the environment. Invasive pathogens must breach the glycan layer before initiating infection.
Arabyan, Narine, Desai, Prerak, Foutouhi, Soraya, Huang, Bihua C, Jeannotte, Richard, Kong, Nguyet, Lebrilla, Carlito B, Park, Dayoung, Shah, Jigna, Weimer, Bart C, Weis, Allison M, Williams, Cynthia C   +11 more
core   +1 more source

Fucosyltransferase 1 Mediates Angiogenesis in Rheumatoid Arthritis [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108009/1/art38648 ...
Amin, Apweiler, Carlyon, Carmeliet, Domino, Domino, Ferens-Sieczkowska, Folkman, Fukushima, Hachicha, Hakomori, Halloran, Hart, Isozaki, Isozaki, Iwamori, Kannagi, Kelly, Koch, Koch, Koch, Larsen, Macartney, Marelli-Berg, Marotte, Marotte, Mathieu, Miyoshi, Moelants, Moremen, Mori, Nakagawa, Palumberi, Park, Proost, Przybysz, Rabquer, Ritchlin, Ruth, Salcedo, Tsou, Volin, Volin, Weinblatt, Yoshida, Zhu   +45 more
core   +1 more source

Detection of Antibody-Dependent Cell-Mediated Cytotoxicity—Supporting Antibodies by NK-92-CD16A Cell Externalization of CD107a: Recognition of Antibody Afucosylation and Assay Optimization

Antibodies, 2023
Antibody-dependent cell-mediated cytotoxicity (ADCC) by natural killer (NK) lymphocytes eliminates cells infected with viruses. Anti-viral ADCC requires three components: (1) antibody; (2) effector lymphocytes with the Fc-IgG receptor CD16A; and (3 ...
Judith Cruz Amaya, Bruce Walcheck, Julie Smith-Gagen, Vincent C. Lombardi, Dorothy Hudig   +4 more
doaj   +1 more source

NF-κB Signaling Is Regulated by Fucosylation in Metastatic Breast Cancer Cells

Biomedicines, 2020
A growing body of evidence indicates that the levels of fucosylation correlate with breast cancer progression and contribute to metastatic disease. However, very little is known about the signaling and functional outcomes that are driven by fucosylation.
Emma H. Doud, Trupti Shetty, Melissa Abt, Amber L. Mosley, Timothy W. Corson, Anand Mehta, Elizabeth S. Yeh   +6 more
doaj   +1 more source

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source

Comparative Proteomic Analysis of Fucosylated Glycoproteins Produced by Bacteroides thetaiotaomicron Under Different Polysaccharide Nutrition Conditions

Frontiers in Microbiology, 2022
Bacteroides thetaiotaomicron, one of the most eminent representative gut commensal Bacteroides species, is able to use the L-fucose in host-derived and dietary polysaccharides to modify its capsular polysaccharides and glycoproteins through a mammalian ...
Xiao Tian, Hao Jiang, Hao Jiang, Binbin Cai, Huxin Feng, Xuan Wang, Guangli Yu, Guangli Yu   +7 more
doaj   +1 more source

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source