Results 81 to 90 of about 17,469 (199)

Natural killer cell activation by respiratory syncytial virus‐specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc‐glycosylation

Clinical & Translational Immunology, 2020
Objectives Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections in infants, and there is no vaccine available.
Elisabeth A vanErp, Anke J Lakerveld, Erik deGraaf, Mads D Larsen, Rutger M Schepp, Agnes L Hipgrave Ederveen, Inge ML Ahout, Cornelis AM deHaan, Manfred Wuhrer, Willem Luytjes, Gerben Ferwerda, Gestur Vidarsson, Puck B vanKasteren   +12 more
doaj   +1 more source

Genetic Pigmentary Disorders: From Molecular Mechanisms to Clinical Manifestations

The Journal of Dermatology, EarlyView.
ABSTRACT Genetic pigmentary disorders represent a diverse group of genetic conditions characterized by alterations in melanin production and transport and melanocyte development, resulting from single‐gene pathological variants. These disorders encompass both hypopigmentary and hyperpigmentary phenotypes, affecting not only skin pigmentation but also ...
Ken Okamura, Tamio Suzuki
wiley   +1 more source

Impact of Acetylated and Non-Acetylated Fucose Analogues on IgG Glycosylation

Antibodies, 2019
The biological activity of therapeutic antibodies is highly influenced by their glycosylation profile. A valuable method for increasing the cytotoxic efficacy of antibodies, which are used, for example, in cancer treatment, is the reduction of core ...
Martina Zimmermann, Janike Ehret, Harald Kolmar, Aline Zimmer   +3 more
doaj   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

The impact of microcarrier culture optimization on the glycosylation profile of a monoclonal antibody [PDF]

, 2013
Microcarriers are widely used for the large-scale culture of attachment-dependent cells with increased cell densities and, ultimately, higher product yield.
Azeredo, Joana, Costa, A. R., Henriques, Mariana, McLoughlin, Niaobh, Oliveira, Rosário, Rodrigues, E., Rudd, Pauline M., Withers, Joanne   +7 more
core   +1 more source

Protein O-Fucosyltransferases: Biological Functions and Molecular Mechanisms in Mammals

Molecules
Domain-specific O-fucosylation is an unusual type of glycosylation, where the fucose is directly attached to the serine or threonine residues in specific protein domains via an O-linkage.
Huilin Hao, Benjamin M. Eberand, Mark Larance, Robert S. Haltiwanger   +3 more
doaj   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Exploring fucosylation in lung cancer: Mechanisms, diagnosis, and therapeutic strategies

Advances in Biomarker Sciences and Technology
Lung cancer remains a global health crisis, responsible for significant morbidity and mortality. Late-stage diagnosis often limits treatment options and patient survival.
Saima Rafique, Wei Ge, Ziyuan Gao, Yan Chen, Jun Xia, Junhong Jiang, Shuang Yang   +6 more
doaj   +1 more source

The balance between GMD and OFUT1 regulates notch signaling pathway activity by modulating notch stability [PDF]

, 2016
The Notch signaling pathway plays an important role in development and physiology. In Drosophila, Notch is activated by its Delta or Serrate ligands, depending in part on the sugar modifications present in its extracellular domain. O-fucosyltransferase-1
Celis, José F. de, Glavic, Álvaro, López-Varea, Ana   +2 more
core   +1 more source

Multi-Path Optimization for Efficient Production of 2′-Fucosyllactose in an Engineered Escherichia coli C41 (DE3) Derivative

Frontiers in Bioengineering and Biotechnology, 2020
2′-fucosyllactose (2′-FL), one of the simplest but most abundant oligosaccharides in human milk, has been demonstrated to have many positive benefits for the healthy development of newborns.
Zhijian Ni, Zhijian Ni, Zhongkui Li, Zhongkui Li, Jinyong Wu, Jinyong Wu, Yuanfei Ge, Yuanfei Ge, Yingxue Liao, Yingxue Liao, Lixia Yuan, Lixia Yuan, Xiangsong Chen, Xiangsong Chen, Jianming Yao, Jianming Yao   +15 more
doaj   +1 more source