Results 91 to 100 of about 18,363 (193)

Potential benefits of phytochemicals against Alzheimer's disease [PDF]

, 2017
Our current therapeutic drugs for Alzheimer's disease are predominantly derived from the alkaloid class of plant phytochemicals. These drugs, such as galantamine and rivastigmine, attenuate the decline in the cholinergic system but, as the alkaloids ...
Wightman, Emma
core   +1 more source

CSF Cholinergic Index, a New Biomeasure of Treatment Effect in Patients With Alzheimer’s Disease

Frontiers in Molecular Neuroscience, 2019
Alzheimer’s disease (AD) is a progressive disease with early degeneration of the central cholinergic neurons. Currently, three of four AD drugs act by inhibiting the acetylcholine (ACh) degrading enzyme, acetylcholinesterase (AChE).
Azadeh Karami, Maria Eriksdotter, Maria Eriksdotter, Ahmadul Kadir, Ahmadul Kadir, Ove Almkvist, Agneta Nordberg, Agneta Nordberg, Taher Darreh-Shori   +8 more
doaj   +1 more source

Evaluation of medication treatment for Alzheimer's disease on clinical evidence [PDF]

, 2014
Objective To formulate the best treatment plan for Alzheimer's disease patients by evaluating the therapeutic efficacy and side effect of various evidence-based programs.
Ling LIU, Meng-qiu LI, Tao CHEN, Wen-wu ZHANG   +3 more
core   +2 more sources

Acetylcholinesterase Inhibitor Ameliorates Early Cardiometabolic Disorders in Fructose-Overloaded Rat Offspring

Pharmaceuticals
Background: We investigate the role of galantamine on autonomic dysfunction associated with early cardiometabolic dysfunction in the offspring of fructose-overloaded rats.
Victor Hugo Martins de Miranda, Camila Paixão Dos Santos, Pietra Petrica Neves, Antonio Viana Nascimento-Filho, Marina Rascio Henriques Dutra, Nathalia Bernardes, Maria Claúdia Irigoyen, Kátia De Angelis   +7 more
doaj   +1 more source

Kynurenine pathway and cognitive impairments in schizophrenia: Pharmacogenetics of galantamine and memantine

Schizophrenia Research: Cognition, 2016
The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) project designed to facilitate the development of new drugs for the treatment of cognitive impairments in people with schizophrenia, identified three drug mechanisms ...
Maju Mathew Koola
doaj   +1 more source

Galantamine as a Potential Treatment for Peripheral Nerve Injuries: Emphasis on Non-Systemic Delivery

Future Pharmacology
Peripheral nerve injuries can lead to significant functional impairments, and treatment options remain limited. Galantamine, widely used for cognitive disorders, has shown potential effects on the peripheral nervous system, making it a candidate for new ...
Mariya Ivanova, Liliya Panayotova-Ovcharova, Detelina Nedyalkova-Petkova, Petar Petkov, Georgi Boshev, Evgeniya Vladeva   +5 more
doaj   +1 more source

Effects of galantamine on attention and memory in Alzheimer's disease measured by computerized neuropsychological tests: results of the Brazilian Multi-Center Galantamine Study (GAL-BRA-01) Efeitos da galantamina sobre a memória e a atenção na doença de Alzheimer medidos por testes neuropsicológicos computadorizados: resultados do Estudo Multicêntrico com Galantamina (GAL-BRA-01)

Arquivos de Neuro-Psiquiatria, 2004
OBJECTIVE: To investigate the effects of galantamine on the performance of patients with mild to moderate Alzheimer's disease (AD) in a computerized neuropsychological test battery (CNTB).
Paulo Caramelli, Márcia L.F. Chaves, Eliasz Engelhardt, João Carlos B. Machado, Rodrigo R. Schultz, Francisco A.C. Vale, Helenice Charchat-Fichman   +6 more
doaj   +1 more source

Perifériás markerek jelentősége Alzheimer-kór diagnózisában és terápiájában = Peripheral markers in the diagnosis and the therapy of Alzheimer`s disease [PDF]

, 2006
A legjelentősebb neurokémiai abnormalitás az Alzheimer-kórban (AK) a központi idegrendszer kolinerg rendszerének csökkent működése, de feltehetőleg a perifériás szövetek is érintettek lehetnek.
Kálmán, János, Rakonczay, Zoltán
core  

Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo [PDF]

N-methyl-d-aspartate receptor (NMDAR) activation can initiate changes in synaptic strength, evident as long-term potentiation (LTP), and is a key molecular correlate of memory formation.
Campbell, Una C., Heffernan, Michele L. R., Hopkins, Seth C., Jeggo, Ross D., Large, Thomas H., Spanswick, David C., Spear, Kerry L., Varney, Mark A.   +7 more
core   +1 more source

Sleep and memory problems: acetylcholine in some neurodegenerative diseases, use of an extended-release formulation of galantamine

Неврология, нейропсихиатрия, психосоматика, 2012
The paper reviews the literature dedicated to an association between sleep and memory problems and acetylcholine (AC) levels. Moderate impairments of circadian rhythms can develop with aging; however, these changes become quite significant in dementia ...
I V Litvinenko
doaj   +1 more source