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Microbial metabolites short chain fatty acids, tight junction, gap junction, and reproduction: a review [PDF]
Frontiers in Cell and Developmental BiologyThe gut microbiota, comprising trillions of bacteria, fungi, and viruses, exists in symbiosis with the host. As the largest microbial ecosystem in the human body.
Lulu Fu +5 more
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Lipid dependence of connexin-32 gap junction channel conformations [PDF]
Nature CommunicationsConnexin-32 (Cx32) gap junction channels (GJCs) mediate intercellular coupling in various tissues, including myelinating Schwann cells. Mutations in Cx32, such as W3S, are associated with X-linked Charcot-Marie-Tooth (CMT1X) disease. Lipids regulate Cx32
Pia Lavriha +3 more
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Metformin suppresses NFE2L1 pathway activation to inhibit gap junction beta protein expression in NSCLC [PDF]
Cancer MedicineObjective Non‐small‐cell lung cancer (NSCLC) is a deadly form of cancer that exhibits extensive intercellular communication which contributed to chemoradiotherapy resistance.
Shuo Yu +9 more
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Current Biology, 2013 In vertebrates and invertebrates, signaling among neurons is most commonly mediated by chemical synapses. At these synapses neurotransmitter released by presynaptic neurons is detected by receptors on the postsynaptic neurons, leading to an influx of ions through the receptors themselves or through channels activated by intracellular signaling ...
Shimizu, Kazumichi, Stopfer, Mark
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Cold Spring Harbor Perspectives in Biology, 2009 Gap junctions are aggregates of intercellular channels that permit direct cell-cell transfer of ions and small molecules. Initially described as low-resistance ion pathways joining excitable cells (nerve and muscle), gap junctions are found joining virtually all cells in solid tissues.
Daniel A, Goodenough, David L, Paul
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Cooperative cell–cell actin network remodeling to perform Gap junction endocytosis
Basic and Clinical Andrology, 2023 Background The endocytosis of Gap junction plaques (GJP) requires cytoskeletal forces to internalize such large membranous structures. Actin, which partners the connexin proteins constituting Gap junctions and is located close to Annular Gap Junctions ...
Dominique Segretain +5 more
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Deficiency of transcription factor Brn4 disrupts cochlear gap junction plaques in a model of DFN3 non-syndromic deafness. [PDF]
PLoS ONE, 2014 Brn4, which encodes a POU transcription factor, is the gene responsible for DFN3, an X chromosome-linked, non-syndromic type of hearing loss. Brn4-deficient mice have a low endocochlear potential (EP), hearing loss, and ultrastructural alterations in ...
Yoshinobu Kidokoro +6 more
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Gap junction plasticity as a mechanism to regulate network-wide oscillations. [PDF]
PLoS Computational Biology, 2018 Cortical oscillations are thought to be involved in many cognitive functions and processes. Several mechanisms have been proposed to regulate oscillations. One prominent but understudied mechanism is gap junction coupling. Gap junctions are ubiquitous in
Guillaume Pernelle +2 more
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An Information Theoretical Analysis of Gap Junction Channels
IEEE Access, 2021 The propagation of molecules, ions and electrochemical signals in various cell types occurs through hundreds of gap junction channels. A gap junction channel is composed of hundreds of units which are further decomposed to hemichannels.
Farrokh Hejri +2 more
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The Journal of Cell Biology, 2005 In the 1960s there was adhesion and there was direct current transfer—a strange neuronal phenomenon whose mechanism was unknown. The two fields only gradually drifted together, but with the report by Revel and Karnovsky (1967) they were united around a distinct, structural correlate soon to ...
William A, Wells, Laura, Bonetta
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