Results 1 to 10 of about 2,836,933 (367)
The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes [PDF]
Nature Communications, 2014 In the brain, astrocytes represent the cellular population that expresses the highest amount of connexins (Cxs). This family of membrane proteins is the molecular constituent of gap junction channels and hemichannels that provide pathways for direct ...
Abudara, Verónica +8 more
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Definitions, 2020 Intercellular connections comprised of complexes of connexin family proteins that permit the transfer of cytoplasmic ions and molecules between connected cells. Each cell contains a hemichannel made up of homo- or hetero-hexamers of connexins.
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Cooperative cell–cell actin network remodeling to perform Gap junction endocytosis [PDF]
Basic and Clinical Andrology, 2023 Background The endocytosis of Gap junction plaques (GJP) requires cytoskeletal forces to internalize such large membranous structures. Actin, which partners the connexin proteins constituting Gap junctions and is located close to Annular Gap Junctions ...
Dominique Segretain +5 more
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Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease. [PDF]
PLoS ONE, 2011 Glutamate released by activated microglia induces excitotoxic neuronal death, which likely contributes to non-cell autonomous neuronal death in neurodegenerative diseases, including amyotrophic lateral sclerosis and Alzheimer's disease.
Hideyuki Takeuchi +18 more
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Regulation of gap junction channels and hemichannels by phosphorylation and redox changes: a revision [PDF]
BMC Cell Biology, 2016 Post-translational modifications of connexins play an important role in the regulation of gap junction and hemichannel permeability. The prerequisite for the formation of functional gap junction channels is the assembly of connexin proteins into ...
Kristin Pogoda +3 more
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Microbial metabolites short chain fatty acids, tight junction, gap junction, and reproduction: a review [PDF]
Frontiers in Cell and Developmental BiologyThe gut microbiota, comprising trillions of bacteria, fungi, and viruses, exists in symbiosis with the host. As the largest microbial ecosystem in the human body.
Lulu Fu +5 more
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Metformin suppresses NFE2L1 pathway activation to inhibit gap junction beta protein expression in NSCLC [PDF]
Cancer MedicineObjective Non‐small‐cell lung cancer (NSCLC) is a deadly form of cancer that exhibits extensive intercellular communication which contributed to chemoradiotherapy resistance.
Shuo Yu +9 more
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Current Biology, 2013 In vertebrates and invertebrates, signaling among neurons is most commonly mediated by chemical synapses. At these synapses neurotransmitter released by presynaptic neurons is detected by receptors on the postsynaptic neurons, leading to an influx of ions through the receptors themselves or through channels activated by intracellular signaling ...
Shimizu, Kazumichi, Stopfer, Mark
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Cold Spring Harbor Perspectives in Biology, 2009 Gap junctions are aggregates of intercellular channels that permit direct cell-cell transfer of ions and small molecules. Initially described as low-resistance ion pathways joining excitable cells (nerve and muscle), gap junctions are found joining virtually all cells in solid tissues.
Daniel A, Goodenough, David L, Paul
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Transfer of mitochondria and endosomes between cells by gap junction internalization
Traffic : the International Journal of Intracellular Transport, 2021 Intercellular organelle transfer has been documented in several cell types and has been proposed to be important for cell‐cell communication and cellular repair. However, the mechanisms by which organelle transfer occurs are uncertain.
R. Norris
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