Gap junctions and epileptic seizures--two sides of the same coin? [PDF]
PLoS ONE, 2011 Electrical synapses (gap junctions) play a pivotal role in the synchronization of neuronal ensembles which also makes them likely agonists of pathological brain activity.
Vladislav Volman +2 more
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Analysis of rod/cone gap junctions from the reconstruction of mouse photoreceptor terminals
eLife, 2022 Electrical coupling, mediated by gap junctions, contributes to signal averaging, synchronization, and noise reduction in neuronal circuits. In addition, gap junctions may also provide alternative neuronal pathways.
Munenori Ishibashi +10 more
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Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons. [PDF]
PLoS Genetics, 2016 Gap junctions are present in both vertebrates and invertebrates from nematodes to mammals. Although the importance of gap junctions has been documented in many biological processes, the molecular mechanisms underlying gap junction dynamics remain unclear.
Lingfeng Meng, Chia-hui Chen, Dong Yan
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Connexins in neurons and glia: targets for intervention in disease and injury
Neural Regeneration Research, 2015 Both neurons and glia throughout the central nervous system are organized into networks by gap junctions. Among glia, gap junctions facilitate metabolic homeostasis and intercellular communication.
Keith B Moore, John O′Brien
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Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments
The Journal of Clinical Investigation, 2023 Connexins are crucial cardiac proteins that form hemichannels and gap junctions. Gap junctions are responsible for the propagation of electrical and chemical signals between myocardial cells and cells of the specialized conduction system in order to ...
Luc Leybaert +8 more
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Frontiers in Cellular Neuroscience, 2021 Electrical synaptic transmission is an essential form of interneuronal communication which is mediated by gap junctions that permit ion flow. Three gene families (connexins, innexins, and pannexins) have evolved to form gap junctional channels.
Qiqian Wang, Shenquan Liu
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Abundance of gap junctions at glutamatergic mixed synapses in adult Mosquitofish spinal cord neurons
Frontiers in Neural Circuits, 2014 Dye-coupling, whole-mount immunohistochemistry for gap junction channel protein connexin 35 (Cx35), and freeze-fracture replica immunogold labeling (FRIL) reveal an abundance of electrical synapses/gap junctions at glutamatergic mixed synapses in the ...
Jose L Serrano-Velez +8 more
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Studying gap junctions with PARIS
eLife, 2019 A new genetically encoded system manipulates the pH inside cells to detect whether they are coupled to each other.
Daniel R Kick, David J Schulz
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Gap Junctions in the Nervous System: Probing Functional Connections Using New Imaging Approaches
Frontiers in Cellular Neuroscience, 2018 Gap junctions are channels that physically connect adjacent cells, mediating the rapid exchange of small molecules, and playing an essential role in a wide range of physiological processes in nearly every system in the body, including the nervous system.
Ao Dong +7 more
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Gap resonance in the classical dynamics of the current-biased Josephson tunnel junctions
Physical Review Research, 2021 This paper reports a novel time-domain expression for the current-response kernels of a Josephson tunnel junction between BCS superconductors with in general different energy gaps, and its use to simulate the classical dynamics of such junctions.
Dmitri V. Averin
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