Distinct roles for innexin gap junctions and hemichannels in mechanosensation
eLife, 2020 Mechanosensation is central to a wide range of functions, including tactile and pain perception, hearing, proprioception, and control of blood pressure, but identifying the molecules underlying mechanotransduction has proved challenging.
Denise S Walker, William R Schafer
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The beneficial effects of cumulus cells and oocyte-cumulus cell gap junctions depends on oocyte maturation and fertilization methods in mice [PDF]
PeerJ, 2016 Cumulus cells are a group of closely associated granulosa cells that surround and nourish oocytes. Previous studies have shown that cumulus cells contribute to oocyte maturation and fertilization through gap junction communication.
Cheng-Jie Zhou +9 more
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Regulation of neuronal axon specification by glia-neuron gap junctions in C. elegans
eLife, 2016 Axon specification is a critical step in neuronal development, and the function of glial cells in this process is not fully understood. Here, we show that C.
Lingfeng Meng +3 more
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Cytoplasmic sharing through apical membrane remodeling
eLife, 2020 Multiple nuclei sharing a common cytoplasm are found in diverse tissues, organisms, and diseases. Yet, multinucleation remains a poorly understood biological property. Cytoplasm sharing invariably involves plasma membrane breaches.
Nora G Peterson +5 more
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Connexin 30 expression and frequency of connexin heterogeneity in astrocyte gap junction plaques increase with age in the rat retina. [PDF]
PLoS ONE, 2013 We investigated age-associated changes in retinal astrocyte connexins (Cx) by assaying Cx numbers, plaque sizes, protein expression levels and heterogeneity of gap junctions utilizing six-marker immunohistochemistry (IHC).
Hussein Mansour +5 more
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Gap Junctions in Ischemia-Related Ventricular Arrhythmia
Majalah Kardiologi Indonesia, 2013 Cardiovascular diseases are the leading cause of death worldwide, with isch-emic heart disease being the most common entity. Ventricular arrhythmia is one of the complications of ischemia that can result in sudden cardiac death.
Berlian Idriansyah Idris, Yoga Yuniadi
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Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila
eLife, 2016 Gap junctions are widely distributed in the brains across species and play essential roles in neural information processing. However, the role of gap junctions in insect cognition remains poorly understood.
Qingqing Liu +6 more
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Gap junctions: historical discoveries and new findings in the Caenorhabditis elegans nervous system
Biology Open, 2020 Gap junctions are evolutionarily conserved structures at close membrane contacts between two cells. In the nervous system, they mediate rapid, often bi-directional, transmission of signals through channels called innexins in invertebrates and connexins ...
Eugene Jennifer Jin +3 more
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Gap junction-mediated regulation of endothelial cellular stiffness
Scientific Reports, 2017 Endothelial monolayers have shown the ability to signal each other through gap junctions. Gap junction-mediated cell-cell interactions have been implicated in the modulation of endothelial cell functions during vascular inflammation.
Takayuki Okamoto +7 more
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PARIS, an optogenetic method for functionally mapping gap junctions
eLife, 2019 Cell-cell communication via gap junctions regulates a wide range of physiological processes by enabling the direct intercellular electrical and chemical coupling.
Ling Wu +4 more
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