Results 101 to 110 of about 24,180 (354)

Gasdermin-D activation promotes NLRP3 activation and host resistance to Leishmania infection

Nature Communications, 2023
Here, de Sá et al. show that Gasdermin-D is transiently activated in Leishmania-infected macrophages and promotes NLRP3 inflammasome activation, but not cell death.
Keyla S. G. de Sá, Luana A. Amaral, Tamara S. Rodrigues, Adriene Y. Ishimoto, Warrison A. C. de Andrade, Leticia de Almeida, Felipe Freitas-Castro, Sabrina S. Batah, Sergio C. Oliveira, Mônica T. Pastorello, Alexandre T. Fabro, Dario S. Zamboni   +11 more
doaj   +1 more source

Pyroptosis: A Developing Foreland of Ovarian Cancer Treatment

Frontiers in Oncology, 2022
Ovarian cancer (OVCA) has the second highest mortality among all gynecological cancers worldwide due to its complexity and difficulty in early-stage diagnosis and a lack of targeted therapy.
Tianyi Liu, Min Hou, Min Hou, Min Hou, Min Hou, Min Hou, Manyu Li, Cheng Qiu, Cheng Qiu, Lin Cheng, Tianyu Zhu, Jinfeng Qu, Lanyu Li   +12 more
doaj   +1 more source

Gasdermin D is required for pyroptosis and secretion of interleukin-1β [PDF]

, 2016
炎性小体是细胞内由caspase-1，ASC，NALP等组成的蛋白复合体，也是先天免疫系统的一个重要组成。炎性小体被激活后会促进白介素1β（IL-1β）和IL-18的剪切与分泌，并触发细胞焦亡的发生。细胞焦亡是近年来发现并证实的一种新的程序性细胞死亡方式，其特征为依赖于caspase-1，并伴随有促炎症因子的释放。尽管其在先天免疫和内毒素休克方面扮演着重要角色，但细胞焦亡被诱导发生的机制仍不清楚。本文通过基于CRISPR-Cas9的基因敲除方法鉴定到了gasderminD（GSDMD ...
万浩强
core  

Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma [PDF]

, 2012
Genome-wide association studies (GWAS) have identified loci reproducibly associated with pulmonary diseases; however, the molecular mechanism underlying these associations are largely unknown.
Bosse, Yohan, Brandsma, Corry-Anke, Couture, Christian, Curtis, Sean P., Daley, Denise, Derry, Jonathan M., Elliott, W. Mark, Hackett, Tillie L., Hao, Ke, Hogg, James C., Koppelman, Gerard, Kulkarni, Amit, Lamontagne, Maxime, Laviolette, Michel, Malkov, Vladislav, Nicholson, Donald W., Nickle, David C., Opiteck, Greg J., Pare, Peter D., Postma, Dirkje S., Reicin, Alise S., Sandford, Andrew, Sin, Don D., Suver, Christine, Timens, Wim, Tsou, Jeffrey A., van den Berge, Maarten, Vessey, Rupert, Zhang, Chunsheng   +28 more
core   +4 more sources

NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation

Science Advances
Gasdermin D (GSDMD) serves as a vital mediator of inflammasome-driven pyroptosis. In our study, we have identified NU6300 as a specific GSDMD inhibitor that covalently interacts with cysteine-191 of GSDMD, effectively blocking its cleavage while not ...
Xueqin Jiang, Xinlu Zhang, Xiaoying Cai, Na Li, Hongyu Zheng, Ming-yang Tang, Jiangli Zhu, Kaiyue Su, Ruijia Zhang, Neng Ye, Jing Peng, Min Zhao, Wenshuang Wu, Jianhong Yang, Haoyu Ye   +14 more
semanticscholar   +1 more source

LPS‐Induced Mitochondrial Damage via SLC41A1‐Mediated Magnesium Ion Efflux Leads to the Pyroptosis of Dental Stem Cells

Advanced Science, EarlyView.
Lipopolysaccharide induces upregulation of the magnesium (Mg2+) efflux transporter solute carrier family 41 member 1 in dental stem cells, leading to a decrease in intracellular Mg2+ concentration and promoting the binding of oligomycin sensitivity‐conferring protein and cyclophilinD.
Yuan Liu, Chenyu Song, Liyuan Zhang, Xue Han, Chaoyuan Li, Yanhong Yan, Ludan Xing, Mengting Si, Bo Yang, Lingyuan Cheng, Akimi Muramatsu, Beizhan Jiang   +11 more
wiley   +1 more source

Pyroptosis‐Inducing Biomaterials Pave the Way for Transformative Antitumor Immunotherapy

Advanced Science
Pyroptosis can effectively overcome immunosuppression and reactivate antitumor immunity. However, pyroptosis initiation is challenging. First, the underlying biological mechanisms of pyroptosis are complex, and a variety of gasdermin family proteins can ...
Hao Yin, Tanzhou Chen, Xiaoqu Hu, Wenting Zhu, Yida Li, Wenjie Sun, Lei Li, Hongmei Zhang, Qinyang Wang   +8 more
doaj   +1 more source

Regulation of Pyroptosis by ncRNA: A Novel Research Direction

Frontiers in Cell and Developmental Biology, 2022
Pyroptosis is a novel form of programmed cell death (PCD), which is characterized by DNA fragmentation, chromatin condensation, cell swelling and leakage of cell contents.
Liyuan Gao, Zhitao Jiang, Yi Han, Yang Li, Xiang Yang   +4 more
doaj   +1 more source

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

Advanced Science, EarlyView.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen, Nian Liu, Qian Tao, Jie Wu, Jinyu Huang, Can Lu, Qiuqiu Li, Liangfang Shen, Xiang Chen, Cong Peng   +9 more
wiley   +1 more source

Pyroptosis and Its Role in Autoimmune Disease: A Potential Therapeutic Target

Frontiers in Immunology, 2022
Autoimmune diseases are a group of heterogeneous diseases with diverse clinical manifestations that can be divided into systemic and organ-specific. The common etiology of autoimmune diseases is the destruction of immune tolerance and the production of ...
Ruixuan You, Ruixuan You, Xinglan He, Xinglan He, Zhuotong Zeng, Zhuotong Zeng, Yi Zhan, Yi Zhan, Yangfan Xiao, Yangfan Xiao, Rong Xiao, Rong Xiao   +11 more
doaj   +1 more source