Recombinant DnaK orally administered protects axenic European sea bass against vibriosis [PDF]
, 2020 Vibrio anguillarum causes high mortality in European sea bass (Dicentrarchus labrax) larviculture and is a hindering factor for successful sustainable aquaculture of this commercially valuable species.
Bajek, Aline +6 more
core +2 more sources
An ancient defense mechanism: Conservation of gasdermin-mediated pyroptosis.
PLoS Biology, 2023 The gasdermins are a family of pore-forming proteins involved in various cellular processes such as cell death and inflammation. A new study in PLOS Biology explores the evolutionary history of gasdermins across metazoans, highlighting the conservation ...
Chengliang Wang, Jianbin Ruan
doaj +1 more source
Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]
, 2019 Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed +3 more
core +2 more sources
GSDME-Dependent Incomplete Pyroptosis Permits Selective IL-1α Release under Caspase-1 Inhibition
iScience, 2020 Summary: Pyroptosis is a form of regulated cell death that is characterized by gasdermin processing and increased membrane permeability. Caspase-1 and caspase-11 have been considered to be essential for gasdermin D processing associated with inflammasome
Emi Aizawa +11 more
doaj +1 more source
Oxypeucedanin alleviates cisplatin-induced intestinal toxicity through impairing caspase-3/gasdermin E signaling. [PDF]
J Vet Med SciOxypeucedanin (OPD) is a compound naturally present in plants such as Peucedanum praeruptorum, a kind of medicinal herb which displays anti-inflammatory activities. However, its protective role on chemotherapy-induced inflammatory injuries has not been well studied.
Wang R +9 more
europepmc +3 more sources
Gasdermin-B promotes invasion and metastasis in breast cancer cells [PDF]
, 2014 Gasdermin B (GSDMB) belongs to the Gasdermin protein family that comprises four members (GSDMA-D). Gasdermin B expression has been detected in some tumor types such as hepatocarcinomas, gastric and cervix cancers; and its overexpression has been related ...
Abril, Sandra +11 more
core +4 more sources
Role of High-Mobility Group Box-1 in Liver Pathogenesis [PDF]
, 2019 High-mobility group box 1 (HMGB1) is a highly abundant DNA-binding protein that can relocate to the cytosol or undergo extracellular release during cellular stress or death. HMGB1 has a functional versatility depending on its cellular location.
Huda, Nazmul +3 more
core +1 more source
Gasdermin E mediates photoreceptor damage by all-trans-retinal in the mouse retina [PDF]
Journal of Biological Chemistry, 2022 The breakdown of all-trans-retinal (atRAL) clearance is closely associated with photoreceptor cell death in dry age-related macular degeneration (AMD) and autosomal recessive Stargardt's disease (STGD1), but its mechanisms remain elusive. Here, we demonstrate that activation of gasdermin E (GSDME) but not gasdermin D promotes atRAL-induced ...
Cai, Binxiang +10 more
openaire +2 more sources
A Comparative Review of Pyroptosis in Mammals and Fish
Journal of Inflammation Research, 2022 Zixi Song,* Jiahong Zou,* Mengya Wang, Zhenwei Chen, Qingchao Wang Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, College of Fisheries ...
Song Z, Zou J, Wang M, Chen Z, Wang Q
doaj
Reconstitution of human pyroptotic cell death in Saccharomyces cerevisiae
Scientific Reports, 2023 Pyroptosis is a lytic form of programmed cell death induced by the activation of gasdermins. The precise mechanism of gasdermin activation by upstream proteases remains incompletely understood.
Yanhao Ji, Christine J. Hawkins
doaj +1 more source