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The p53 gene expression and its developmental regulation in schistosomes [PDF]
We have studied the gene expression, especially of the oncoproteins, and its regulation in schistosomes. Schistosomes have a complex life cycle with a defined dimorphic lifestyle. The parasite are so far unique in biology in expressing oncogene products in their adult stage. In order to characterize the expression and developmental regulation, a lambda
Tanaka, Manami+2 more
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Developmental regulation of GABAergic gene expression in forebrain cholinergic neurons
Acetylcholine and GABA are often co-released, including from VIP-expressing neurons of the cortex, cortically-projecting neurons of the globus pallidus externus and basal forebrain, and hippocampal-projecting neurons of the medial septum. The co-release of the functionally antagonistic neurotransmitters GABA and acetylcholine (ACh) greatly expands the ...
Adam J. Granger+4 more
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Transcriptome Sequencing and Developmental Regulation of Gene Expression in Anopheles aquasalis [PDF]
Anopheles aquasalis is a major malaria vector in coastal areas of South and Central America where it breeds preferentially in brackish water. This species is very susceptible to Plasmodium vivax and it has been already incriminated as responsible vector in malaria outbreaks.
Costa-da-Silva, André L+12 more
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From genes to patterns: a framework for modeling the emergence of embryonic development from transcriptional regulation. [PDF]
Understanding embryonic patterning, the process by which groups of cells are partitioned into distinct identities defined by gene expression, is a central challenge in developmental biology.
Garcia-Guillen J, El-Sherif E.
europepmc +2 more sources
Thermal and developmental regulation of gene expression in Trypanosoma cruzi [PDF]
Soares, C. M. A.+6 more
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Maternal diabetes and obesity in pregnancy are well-known risk factors for structural birth defects, including neural tube defects and congenital heart defects.
Man Zhang+4 more
doaj +1 more source
Maternal diabetes in early pregnancy increases the risk for birth defects in the offspring, particularly heart, and neural tube defects. While elevated glucose levels are characteristic for diabetic pregnancies, these are also accompanied by ...
Claudia Kappen+3 more
doaj +1 more source
Broad spectrum of CRISPR-induced edits in an embryonic lethal gene
Mendelian genetics poses practical limitations on the number of mutant genes that can be investigated simultaneously for their roles in embryonic development in the mouse.
Kayla T. B. Fuselier+2 more
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Developmental Regulation of Angiotensinogen Gene Expression in Sheep [PDF]
It has been suggested that the liver is not the main source of angiotensinogen during fetal life in rats, but that the kidney is an important site of fetal angiotensinogen synthesis. In an effort to determine if this phenomenon is specific to the rat or applicable to other species, we compared the ontogenic changes in hepatic and renal angiotensinogen ...
Stanley Perlman+2 more
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Differential responses to maternal diabetes in embryo and visceral yolk sac
Introduction: Maternal diabetes during pregnancy is well known to be associated with a higher risk for structural birth defects in the offspring. Recent searches for underlying mechanisms have largely focused on aberrant processes in the embryo itself ...
J. Michael Salbaum+3 more
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