Results 11 to 20 of about 743,593 (306)

Differential responses to maternal diabetes in embryo and visceral yolk sac

open access: yesFrontiers in Cell and Developmental Biology, 2023
Introduction: Maternal diabetes during pregnancy is well known to be associated with a higher risk for structural birth defects in the offspring. Recent searches for underlying mechanisms have largely focused on aberrant processes in the embryo itself ...
J. Michael Salbaum   +3 more
doaj   +1 more source

Developmental Regulation of Angiotensinogen Gene Expression in Sheep [PDF]

open access: yesPediatric Research, 1990
It has been suggested that the liver is not the main source of angiotensinogen during fetal life in rats, but that the kidney is an important site of fetal angiotensinogen synthesis. In an effort to determine if this phenomenon is specific to the rat or applicable to other species, we compared the ontogenic changes in hepatic and renal angiotensinogen ...
Olson, Ann Louise   +2 more
openaire   +2 more sources

TempShift Reveals the Sequential Development of Human Neocortex and Skewed Developmental Timing of Down Syndrome Brains

open access: yesBrain Sciences, 2023
Development is a complex process involving precise regulation. Developmental regulation may vary in tissues and individuals, and is often altered in disorders.
Yuqiu Zhou, Li Tao, Ying Zhu
doaj   +1 more source

chHDAC11 mRNA Expression During Prenatal and Postnatal Chicken (Gallus gallus) Brain Development

open access: yesCaspian Journal of Neurological Sciences, 2022
Background: Histone deacetylation plays an essential role in transcriptional regulation of cell cycle progression and other evolutionary processes. Several results confirm the importance of the latest found HDAC11 gene to deacetylate histone core in ...
Farzam Ajamian   +4 more
doaj   +1 more source

BUB-1 targets PP2A:B56 to regulate chromosome congression during meiosis I in C. elegans oocytes

open access: yeseLife, 2020
Protein Phosphatase 2A (PP2A) is a heterotrimer composed of scaffolding (A), catalytic (C), and regulatory (B) subunits. PP2A complexes with B56 subunits are targeted by Shugoshin and BUBR1 to protect centromeric cohesion and stabilise kinetochore ...
Laura Bel Borja   +9 more
doaj   +1 more source

Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders

open access: yesNature Communications, 2021
Mutations in the ARID1B subunit of the BAF chromatin remodeling complex are associated with the neurodevelopmental Coffin-Siris syndrome. Here the authors reveal that there is a transition from ARID1A-containing complexes to ARID1B during cranial neural ...
Luca Pagliaroli   +14 more
doaj   +1 more source

The regulation of Hox gene expression during animal development [PDF]

open access: yes, 2013
Hox genes encode a family of transcriptional regulators that elicit distinct developmental programmes along the head-to-tail axis of animals. The specific regional functions of individual Hox genes largely reflect their restricted expression patterns ...
Alonso, Claudio R, Mallo, Moisés
core   +1 more source

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse

open access: yesNeurobiology of Disease, 2022
Genetic variation in voltage-gated sodium (NaV) channels is a significant contributor to neurodevelopmental disorders. NaV channel alpha subunits are encoded by the SCNxA family and four are predominately expressed in the brain: SCN1A, SCN2A, SCN3A, and ...
Jacqueline Heighway   +8 more
doaj   +1 more source

Stochastic neural network models for gene regulatory networks [PDF]

open access: yes, 2003
Recent advances in gene-expression profiling technologies provide large amounts of gene expression data. This raises the possibility for a functional understanding of genome dynamics by means of mathematical modelling.
Burrage, K., Tian, T.
core   +2 more sources

Developmental regulation and expression of the zebrafish connexin43 gene [PDF]

open access: yesDevelopmental Dynamics, 2005
AbstractWe cloned and sequenced the zebrafish (Danio rerio) connexin43 (Cx43α1) gene. The predicted protein sequence shows a high degree of sequence conservation. Transcript analyses revealed multiple transcription start sites and a potential alternative transcript encoding a N‐terminally truncated Cx43α1 protein.
Bishwanath, Chatterjee   +12 more
openaire   +2 more sources

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