Results 21 to 30 of about 918,759 (321)
Developmental regulation of proenkephalin gene expression in osteoblasts. [PDF]
Molecular Endocrinology, 1995 Proenkephalin (PENK), a classically defined opioid gene, was originally thought to be expressed almost exclusively in the mature nervous and neuroendocrine systems. In the last few years, it was demonstrated, however, that high levels of PENK messenger RNA and PENK-derived peptides are expressed in embryonic mesenchymal tissues during differentiation ...
Simone Ben-zakine +4 more
openaire +3 more sources
BUB-1 targets PP2A:B56 to regulate chromosome congression during meiosis I in C. elegans oocytes
eLife, 2020 Protein Phosphatase 2A (PP2A) is a heterotrimer composed of scaffolding (A), catalytic (C), and regulatory (B) subunits. PP2A complexes with B56 subunits are targeted by Shugoshin and BUBR1 to protect centromeric cohesion and stabilise kinetochore ...
Laura Bel Borja +9 more
doaj +1 more source
Nature Communications, 2021 Mutations in the ARID1B subunit of the BAF chromatin remodeling complex are associated with the neurodevelopmental Coffin-Siris syndrome. Here the authors reveal that there is a transition from ARID1A-containing complexes to ARID1B during cranial neural ...
Luca Pagliaroli +14 more
doaj +1 more source
A chicken homeo box gene with developmentally regulated expression [PDF]
FEBS Letters, 1989 Several homeo box sequences were isolated from a chicken (Gallus domesticus) genomic library. One phage, λGG7, was chosen for further study and the single homeo box sequence it contains was characterized. The sequence of the homeo box revealed it to be a distant member of the Antp class of homeo boxes.
Yosef Gruenbaum, Abraham Fainsod
openaire +3 more sources
Dynamic genetic regulation of gene expression during cellular differentiation
Science, 2019 Variants affect gene expression over time Genetic variation drives the spectrum of human phenotypes but in some cases has been linked to pathological conditions. Strober et al.
B. Strober +6 more
semanticscholar +1 more source
F1000Research, 2019 Since its discovery more than 25 years ago, great progress has been made in our understanding of the unfolded protein response (UPR), a homeostatic mechanism that adjusts endoplasmic reticulum (ER) function to satisfy the physiological demands of the ...
G. Elif Karagöz +2 more
doaj +1 more source
Sex Biased Gene Expression Profiling of Human Brains at Major Developmental Stages
Scientific Reports, 2016 There are many differences in brain structure and function between males and females. However, how these differences were manifested during development and maintained through adulthood are still unclear.
Lei Shi, Zhe Zhang, B. Su
semanticscholar +1 more source
MicroRNAs preferentially target the genes with high transcriptional regulation complexity [PDF]
Biochem Biophys Res Commun., 352:733-738, 2007, 2006 Over the past few years, microRNAs (miRNAs) have emerged as a new prominent class of gene regulatory factors that negatively regulate expression of approximately one-third of the genes in animal genomes at post-transcriptional level. However, it is still unclear why some genes are regulated by miRNAs but others are not, i.e.
arxiv +1 more source
Conservation of peripheral nervous system formation mechanisms in divergent ascidian embryos
eLife, 2020 Ascidians with very similar embryos but highly divergent genomes are thought to have undergone extensive developmental system drift. We compared, in four species (Ciona and Phallusia for Phlebobranchia, Molgula and Halocynthia for Stolidobranchia), gene ...
Joshua F Coulcher +8 more
doaj +1 more source
Dynamic association of NUP98 with the human genome. [PDF]
PLoS Genetics, 2013 Faithful execution of developmental gene expression programs occurs at multiple levels and involves many different components such as transcription factors, histone-modification enzymes, and mRNA processing proteins.
Yun Liang +4 more
doaj +1 more source