Results 71 to 80 of about 918,759 (321)

Zebrafish rest regulates developmental gene expression but not neurogenesis [PDF]

Development, 2012
The transcriptional repressor Rest (Nrsf) recruits chromatin-modifying complexes to RE1 ‘silencer elements’, which are associated with hundreds of neural genes. However, the requirement for Rest-mediated transcriptional regulation of embryonic development and cell fate is poorly understood. Conflicting views of the role of Rest in controlling cell fate
Xiayang Xie, Cara E. Moravec, Jeff S. Mumm, Sarah J. Wanner, Andrew Taibi, Victoria E. Prince, Crystal E. Love, Howard I. Sirotkin, Fatma O. Kok   +8 more
openaire   +3 more sources

Dynamics of DNA Methylation and Its Functions in Plant Growth and Development

Frontiers in Plant Science, 2021
Epigenetic modifications in DNA bases and histone proteins play important roles in the regulation of gene expression and genome stability. Chemical modification of DNA base (e.g., addition of a methyl group at the fifth carbon of cytosine residue ...
Suresh Kumar, Trilochan Mohapatra
doaj   +1 more source

Developmental regulation of calmodulin gene expression in rat brain and skeletal muscle.

Cell Regulation, 1991
Three different calmodulin genes that encode the identical protein have been identified in the rat (Nojima, 1989); however, calmodulin gene expression at the various stages of tissue differentiation and maturation has not been previously determined.
Jacqueline Weinman, B. Gaspera, André Dautigny, D. P. Dinh, J. Wang, H. Nojima, Serge Weinman   +6 more
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Single gene analysis in yeast suggests nonequilibrium regulatory dynamics for transcription

Nature Communications
Fluctuations in the initiation rate of transcription, the first step in gene expression, ensue from the stochastic behavior of the molecular process that controls transcription.
Robert Shelansky, Sara Abrahamsson, Christopher R. Brown, Michael Doody, Tineke L. Lenstra, Daniel R. Larson, Hinrich Boeger   +6 more
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

NELF potentiates gene transcription in the Drosophila embryo. [PDF]

PLoS ONE, 2010
A hallmark of genes that are subject to developmental regulation of transcriptional elongation is association of the negative elongation factor NELF with the paused RNA polymerase complex.
Xiaoling Wang, Saiyu Hang, Lisa Prazak, J Peter Gergen   +3 more
doaj   +1 more source

Functional Characteristics of Gene Expression Motifs with Single and Dual Strategies of Regulation [PDF]

Biomed. Phys. Eng. Express, 2 , 025009(2016), 2016
Transcriptional regulation by transcription factors and post-transcriptional regulation by microRNAs constitute two major modes of regulation of gene expression. While gene expression motifs incorporating solely transcriptional regulation are well investigated, the dynamics of motifs with dual strategies of regulation, i.e., both transcriptional and ...
arxiv   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Distinguishing epigenetic marks of developmental and imprinting regulation

Epigenetics & Chromatin, 2010
Background The field of epigenetics is developing rapidly, however we are only beginning to comprehend the complexity of its influence on gene regulation.
McEwen Kirsten R, Ferguson-Smith Anne C
doaj   +1 more source