Results 31 to 40 of about 59,169,857 (243)

Genotyping 1000 yeast strains by next-generation sequencing

BMC Genomics, 2013
Background The throughput of next-generation sequencing machines has increased dramatically over the last few years; yet the cost and time for library preparation have not changed proportionally, thus representing the main bottleneck for sequencing large
Wilkening Stefan, Tekkedil Manu M, Lin Gen, Fritsch Emilie S, Wei Wu, Gagneur Julien, Lazinski David W, Camilli Andrew, Steinmetz Lars M   +8 more
doaj   +1 more source

Strong isolation by distance among local populations of an endangered butterfly species (Euphydryas aurinia)

Ecology and Evolution, 2021
The marsh fritillary (Euphydryas aurinia) is a critically endangered butterfly species in Denmark known to be particularly vulnerable to habitat fragmentation due to its poor dispersal capacity.
Cino Pertoldi, Aritz Ruiz‐Gonzalez, Simon Bahrndorff, Nanna Renee Lauridsen, Thøger Nisbeth Henriksen, Anne Eskildsen, Toke Thomas Høye   +6 more
doaj   +1 more source

Analysis of Genetic Diversity and Development of A Core Collection in Walnut (Juglans regia L.) Germplasm Native to China via Genotyping-by-Sequencing

Agronomy, 2023
Popular knowledge of the population structure and genetic diversity of a plant species is essential for designing improvement strategies. The genotyping-by-sequencing (GBS) approach has been used to simplify complex genomes and has become a popular high ...
Jing Ren, Yu-An Wang, Xiao-Kang Zhou, Kai-Wen Xie, Fu-Jun Han, Hai Peng, Xiao-Yong Liu   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Chronic radiation exposure at Chernobyl shows no effect on genetic diversity in the freshwater crustacean, Asellus aquaticus thirty years on

Ecology and Evolution, 2019
Analysis of genetic diversity represents a fundamental component of ecological risk assessments in contaminated environments. Many studies have assessed the genetic implications of chronic radiation exposure at Chernobyl, generally recording an elevated ...
Neil Fuller, Alex T. Ford, Adélaïde Lerebours, Dmitri I. Gudkov, Liubov L. Nagorskaya, Jim T. Smith   +5 more
doaj   +1 more source

Continent‐wide population genomic structure and phylogeography of North America’s most destructive conifer defoliator, the spruce budworm (Choristoneura fumiferana)

Ecology and Evolution, 2020
The spruce budworm, Choristoneura fumiferana, is presumed to be panmictic across vast regions of North America. We examined the extent of panmixia by genotyping 3,650 single nucleotide polymorphism (SNP) loci in 1975 individuals from 128 collections ...
Lisa M. Lumley, Esther Pouliot, Jérôme Laroche, Brian Boyle, Bryan M. T. Brunet, Roger C. Levesque, Felix A. H. Sperling, Michel Cusson   +7 more
doaj   +1 more source

Genome-wide investigations reveal the population structure and selection signatures of Nigerian cattle adaptation in the sub-Saharan tropics

BMC Genomics, 2022
Background Cattle are considered to be the most desirable livestock by small scale farmers. In Africa, although comprehensive genomic studies have been carried out on cattle, the genetic variations in indigenous cattle from Nigeria have not been fully ...
David H. Mauki, Abdulfatai Tijjani, Cheng Ma, Said I. Ng’ang’a, Akanbi I. Mark, Oscar J. Sanke, Abdussamad M. Abdussamad, Sunday C. Olaogun, Jebi Ibrahim, Philip M. Dawuda, Godwin F. Mangbon, Rudovick R. Kazwala, Paul S. Gwakisa, Ting-Ting Yin, Yan Li, Min-Sheng Peng, Adeniyi C. Adeola, Ya-Ping Zhang   +17 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Next Generation Characterisation of Cereal Genomes for Marker Discovery

Biology, 2013
Cereal crops form the bulk of the world’s food sources, and thus their importance cannot be understated. Crop breeding programs increasingly rely on high-resolution molecular genetic markers to accelerate the breeding process.
Paul Visendi, Jacqueline Batley, David Edwards   +2 more
doaj   +1 more source