Results 41 to 50 of about 56,079,611 (245)

Genome-wide investigations reveal the population structure and selection signatures of Nigerian cattle adaptation in the sub-Saharan tropics

BMC Genomics, 2022
Background Cattle are considered to be the most desirable livestock by small scale farmers. In Africa, although comprehensive genomic studies have been carried out on cattle, the genetic variations in indigenous cattle from Nigeria have not been fully ...
David H. Mauki, Abdulfatai Tijjani, Cheng Ma, Said I. Ng’ang’a, Akanbi I. Mark, Oscar J. Sanke, Abdussamad M. Abdussamad, Sunday C. Olaogun, Jebi Ibrahim, Philip M. Dawuda, Godwin F. Mangbon, Rudovick R. Kazwala, Paul S. Gwakisa, Ting-Ting Yin, Yan Li, Min-Sheng Peng, Adeniyi C. Adeola, Ya-Ping Zhang   +17 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Next Generation Characterisation of Cereal Genomes for Marker Discovery

Biology, 2013
Cereal crops form the bulk of the world’s food sources, and thus their importance cannot be understated. Crop breeding programs increasingly rely on high-resolution molecular genetic markers to accelerate the breeding process.
Paul Visendi, Jacqueline Batley, David Edwards   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Design of a high density SNP genotyping assay in the pig using SNPs identified and characterized by next generation sequencing technology [PDF]

, 2009
A systematic review of the literature was carried out to determine the evidence for the reliability and validity of the assessment methods used in veterinary medical education. The review followed the approach used by the Best Evidence Medical Education (
Rothschild, M. F., Clark Richard, Milan, D., Ramos Antonio M., Mark S Hansen, Martien A M Groenen, Affara, Nabeel A., Law, Andy S., Taylor, Jeremy F., Antonio M Ramos, Richard Clark, Andreia J Amaral, Schook Lawrence B., Megens, H.J.W.C., Max F. Rothschild, Crooijmans, Richard P.M.A., Bendixen, C., Taylor, J. F., Andy S Law, Denis Milan, Groenen, M.A.M., Robert D. Schnabel, Megens, H. J., Taylor Jeremy F., Hansen Mark S., Kerstens, H.H.D., Hansen, M. S., Crooijmans, R.P.M.A., Lawrence B Schook, Affara, N.A., Rohrer, Gary A., Tim P. L. Smith, Nabeel A. Affara, Tim P L Smith, Schnabel, R. D., Danny J Nonneman, Archibald Alan L., Law, A. S., Dehais Patrick, Nonneman Danny J., Law Andy S., Zhi-Liang Hu, Affara Nabeel A., Groenen, Martien A.M., Nonneman, Danny J., Archibald, A. L., Hedegaard Jakob, Ralph T Wiedmann, Danny J. Nonneman, Bendixen, Christian, Smith, T. P., Nabeel A Affara, Lawrence B. Schook, Hedegaard, Jakob, Crooijmans, R. P., Groenen, M. A., Carol Churcher, Hu, Z. L., Rohrer, G. A., Dehais, Patrice, Churcher, Carol, Clark, Richard, Megens, Hendrik-Jan, Hindrik H. Kerstens, Bendixen Christian, Beever, J. E., Churcher Carol, Amaral, Andreia J., Jeremy F Taylor, Zhi-Liang, Hu, Ralph T. Wiedmann, Gary A. Rohrer, Curt P. Van Tassell, Andy S. Law, Beever Jonathan E., Affara, N. A., Patrick Dehais, Rohrer Gary A., Dehais, P., Antonio M. Ramos, Gary A Rohrer, Ramos, A. M., Martien A. M. Groenen, Wiedmann, R. T., Kerstens, Hindrik H., Richard P. M. A. Crooijmans, Jakob Hedegaard, Churcher, C., Ramos, Antonio M., Hu Zhi-Liang, Kerstens Hindrik H., Alan L Archibald, Hansen, Mark S., Amaral, A. J., Schook, Lawrence B., Wiedmann Ralph T., Jonathan E. Beever, Milan Denis, Hedegaard, J., Christian Bendixen, Van Tassell Curt P., Mark S. Hansen, Kerstens, H. H., Andreia J. Amaral, Crooijmans Richard P. M. A., Groenen Martien A. M., Alan L. Archibald, Richard P M A Crooijmans, Amaral Andreia J., Jonathan E Beever, Rothschild, Max F., Rothschild Max F., Megens Hendrik-Jan, Smith, Tim P.L., Wiedmann, Ralph T., Jeremy F. Taylor, Clark, R., Milan, Denis, Archibald, Alan L., Nonneman, D. J., Hindrik H Kerstens, Schook, L. B., Hendrik-Jan Megens, Smith Tim P. L., Ramos, A., Van Tassell, Curt P., Beever, Jonathan E., Max F Rothschild, Schnabel Robert D., Robert D Schnabel, Amaral, A.J., Van Tassell, C. P., Curt P Van Tassell, Schnabel, Robert D.   +133 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Fine Mapping, Transcriptome Analysis, and Marker Development for Y2, the Gene That Conditions β-Carotene Accumulation in Carrot (Daucus carota L.)

G3: Genes, Genomes, Genetics, 2017
Domesticated carrots, Daucus carota subsp. sativus, are the richest source of β-carotene in the US diet, which, when consumed, is converted into vitamin A, an essential component of eye health and immunity.
Shelby Ellison, Douglas Senalik, Hamed Bostan, Massimo Iorizzo, Philipp Simon   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Adapting Genotyping-by-Sequencing for Rice F2 Populations

G3: Genes, Genomes, Genetics, 2017
Rapid and cost-effective genotyping of large mapping populations can be achieved by sequencing a reduced representation of the genome of every individual in a given population, and using that information to generate genetic markers.
Tomoyuki Furuta, Motoyuki Ashikari, Kshirod K. Jena, Kazuyuki Doi, Stefan Reuscher   +4 more
doaj   +1 more source

Comparisons of improved genomic predictions generated by different imputation methods for genotyping by sequencing data in livestock populations

Journal of Animal Science and Biotechnology, 2020
Background Genotyping by sequencing (GBS) still has problems with missing genotypes. Imputation is important for using GBS for genomic predictions, especially for low depths, due to the large number of missing genotypes.
Xiao Wang, Guosheng Su, Dan Hao, Mogens Sandø Lund, Haja N. Kadarmideen   +4 more
doaj   +1 more source