Results 1 to 10 of about 2,762 (157)

The structural basis for synergistic inhibition of geranylgeranyl diphosphate synthase with stereoisomeric triazole bisphosphonates [PDF]

Structural Dynamics
Several incurable cancers are characterized by abnormal protein production and secretion. A prime example being multiple myeloma and its excessive production of non-functional antibodies (M protein).
Andrew Pham, Sarah Holstein, Gloria Borgstahl   +2 more
doaj   +5 more sources

Upregulated GBP2 exacerbates Parkinson's disease pathogenesis by impairing NIX-dependent mitophagy [PDF]

Redox Biology
Parkinson's disease (PD), characterized by dopaminergic neuron loss, still lacks disease-modifying therapies due to incompletely understood mechanisms. Guanylate-binding proteins (GBPs) are well-known immune regulators, but their roles in PD are largely ...
Wenqi Cui, Tianlu Wang, Juan Feng
doaj   +2 more sources

Geranylgeranyl diphosphate synthase: Role in human health, disease and potential therapeutic target [PDF]

Clinical and Translational Medicine, 2023
Geranylgeranyl diphosphate synthase (GGDPS), an enzyme in the isoprenoid biosynthesis pathway, is responsible for the production of geranylgeranyl pyrophosphate (GGPP).
Molly E. Muehlebach, Sarah A. Holstein
doaj   +2 more sources

The effects of geranylgeranyl diphosphate synthase inhibitor treatment on osteoblast biology and application in a conditioned media model of myeloma bone disease [PDF]

Bone Reports
Myeloma bone disease (MBD) is characterized by tumor-induced osteoclast activation with concomitant suppression of osteoblast activity. Nitrogen bisphosphonates (NBPs), including zoledronic acid (ZA), are a mainstay of MBD treatment, due to their anti ...
Molly E. Muehlebach, Sarah A. Holstein
doaj   +2 more sources

Updates on protein-prenylation and associated inherited retinopathies [PDF]

Frontiers in Ophthalmology
Membrane-anchored proteins play critical roles in cell signaling, cellular architecture, and membrane biology. Hydrophilic proteins are post-translationally modified by a diverse range of lipid molecules such as phospholipids ...
Sudhat Ashok, Sriganesh Ramachandra Rao, Sriganesh Ramachandra Rao, Sriganesh Ramachandra Rao   +3 more
doaj   +2 more sources

Mevalonate pathway inhibition reduces bladder cancer metastasis by modulating RhoB protein stability and integrin β1 localization [PDF]

Communications Biology
The progression and outcome of bladder cancer (BLCA) are critically affected by the propensity of tumor metastasis. Our previous study revealed that activation of the mevalonate (MVA) pathway promoted migration of BLCA cells; however, the exact mechanism
Gang Wang, Tianchen Peng, Liang Chen, Kangping Xiong, Lingao Ju, Kaiyu Qian, Yi Zhang, Yu Xiao, Xinghuan Wang   +8 more
doaj   +2 more sources

Geranylgeranylated SCFFBXO10 regulates selective outer mitochondrial membrane proteostasis and function [PDF]

Cell Reports
Summary: Compartment-specific cellular membrane protein turnover is not well understood. We show that FBXO10, the interchangeable component of the cullin-RING-ligase 1 complex, undergoes lipid modification with geranylgeranyl isoprenoid at cysteine953 ...
Sameer Ahmed Bhat, Zahra Vasi, Liping Jiang, Shruthi Selvaraj, Rachel Ferguson, Sanaz Salarvand, Anish Gudur, Ritika Adhikari, Veronica Castillo, Hagar Ismail, Avantika Dhabaria, Beatrix Ueberheide, Shafi Kuchay   +12 more
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A Requirement of Protein Geranylgeranylation for Chemokine Receptor Signaling and Th17 Cell Function in an Animal Model of Multiple Sclerosis

Frontiers in Immunology, 2021
Precisely controlled lymphocyte migration is critically required for immune surveillance and successful immune responses. Lymphocyte migration is strictly regulated by chemokines and chemokine receptors.
Gregory Swan, Gregory Swan, Jia Geng, Eunchong Park, Quanquan Ding, John Zhou, Ciana Walcott, Junyi J. Zhang, Hsin-I Huang, Gianna Elena Hammer, Donghai Wang, Donghai Wang   +11 more
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Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase [PDF]

Journal of Biological Chemistry, 2009
Rab geranylgeranyl transferase (RGGT) catalyzes the post-translational geranylgeranyl (GG) modification of (usually) two C-terminal cysteines in Rab GTPases. Here we studied the mechanism of the Rab geranylgeranylation reaction by bisphosphonate analogs in which one phosphonate group is replaced by a carboxylate (phosphonocarboxylate, PC).
Baron, Rudi A., Tavaré, Richard, Figueiredo, Ana C., Błazewska, Katarzyna M., Kashemirov, Boris A., McKenna, Charles E., Ebetino, Frank H., Taylor, Adam, Rogers, MIchael J., Coxon, Fraser P., C Seabra, Miguel   +10 more
openaire   +6 more sources

GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary. [PDF]

PLoS Genetics, 2017
Folliculogenesis is a progressive and highly regulated process, which is essential to provide ova for later reproductive life, requires the bidirectional communication between the oocyte and granulosa cells.
Chen Jiang, Fan Diao, Yong-Juan Sang, Na Xu, Rui-Lou Zhu, Xiu-Xing Wang, Zhong Chen, Wei-Wei Tao, Bing Yao, Hai-Xiang Sun, Xing-Xu Huang, Bin Xue, Chao-Jun Li   +12 more
doaj   +1 more source