Results 11 to 20 of about 2,762 (157)

GGPS1 Promoter Variant (rs3806394) Is Associated With Larger Simple Renal Cysts via Reduced GGPPS Expression. [PDF]

Hum Mutat
Objective We are aimed at investigating the association between the size of simple renal cyst (SRC) and the expression of geranylgeranyl pyrophosphate synthase (GGPPS), which can induce renal cyst formation after its deletion. Methods Seventy‐seven patients who received renal cyst decortication were enrolled.
Wang K, Tang T, Xu T, Chen Z, Gou L, Wang Y, Wang D, Wu J, Wang X, Xue B, Xu X.   +10 more
europepmc   +2 more sources

Design and Evaluation of Bivalent K-Ras Inhibitors That Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I. [PDF]

Chemistry
Chemical inhibition of K‐Ras posttranslational prenylation represents a promising strategy against aggressive cancers. A structure‐based design produces piperidine‐based peptidomimetics conjugated to cationic modules, effectively inhibiting FTase and GGTase I at single‐digit nanomolar concentrations.
Horiuchi N, Omer R, Sugino F, Ogino N, Inoue Y, Aslamuzzaman K, Suzuki T, Sebti SM, Ohkanda J.   +8 more
europepmc   +2 more sources

CAAX Geranylgeranyl Transferase Transfers Farnesyl as Efficiently as Geranylgeranyl to RhoB [PDF]

Journal of Biological Chemistry, 1995
RhoB, a small GTP-binding protein, was shown previously to contain farnesyl (C-15) as well as geranylgeranyl (C-20) groups (Adamson, P., Marshall, C. J., Hall, A., and Tilbrook, P. A. (1992) J. Biol. Chem. 267, 20033-20038). The COOH-terminal sequence of the protein is CCKVL.
S A, Armstrong, V C, Hannah, J L, Goldstein, M S, Brown   +3 more
openaire   +2 more sources

Geranylgeranyl Switching Regulates [PDF]

Structure, 2003
AbstractRab GTPases, key regulators of membrane targeting and fusion, require the covalent attachment of geranylgeranyl lipids to their C terminus for function. To elucidate the role of lipid in Rab recycling, we have determined the crystal structure of Rab guanine nucleotide dissociation inhibitor (αGDI) in complex with a geranylgeranyl (GG) ligand ...
An, Yu, Shao, Ying, Alory, Christelle, Matteson, Jeanne, Sakisaka, Toshiaki, Chen, Wei, Gibbs, Richard A, Wilson, Ian A, Balch, William E   +8 more
openaire   +1 more source

Inhibition of Geranylgeranyl Transferase-I Decreases Cell Viability of HTLV-1-Transformed Cells

Viruses, 2011
Human T-cell leukemia virus type-1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL), an aggressive and highly chemoresistant malignancy.
Cynthia A. Pise-Masison, Kyung-Jin Jung, John N. Brady, Claudio Fenizia, Katherine M. McKinnon, Dustin C. Edwards   +5 more
doaj   +1 more source

Alendronate prevents angiotensin II-induced collagen I production through geranylgeranylation-dependent RhoA/Rho kinase activation in cardiac fibroblasts

Journal of Pharmacological Sciences, 2015
Collagen I is the main component of extracellular matrix in cardiac fibrosis. Our previous studies have reported inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced cardiac fibrosis, while the exact molecular mechanism was still ...
Yang Ye, Xue Lv, Mei-hui Wang, Jun Zhu, Shi-quan Chen, Chen-yang Jiang, Guo-sheng Fu   +6 more
doaj   +1 more source

Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome

Journal of Lipid Research, 2009
Hutchinson-Gilford progeria syndrome (HGPS) is caused by the synthesis of a truncated prelamin A, commonly called progerin, that contains a carboxyl-terminal farnesyl lipid anchor.
Brandon S.J. Davies, Shao H. Yang, Emily Farber, Roger Lee, Suzanne B. Buck, Douglas A. Andres, H. Peter Spielmann, Brian J. Agnew, Fuyuhiko Tamanoi, Loren G. Fong, Stephen G. Young   +10 more
doaj   +1 more source

Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors

Molecules, 2017
The enzyme geranylgeranyl diphosphate synthase (GGDPS) catalyzes the synthesis of the 20-carbon isoprenoid geranylgeranyl diphosphate (GGPP). GGPP is the isoprenoid donor for protein geranylgeranylation reactions catalyzed by the enzymes geranylgeranyl ...
Staci L. Haney, Veronica S. Wills, David F. Wiemer, Sarah A. Holstein   +3 more
doaj   +1 more source

Synthesis of the 6-Substituted Imidazo[1,2-a]Pyridine-3-yl-2- Phosphonopropionic Acids as Potential Inhibitors of Rab Geranylgeranyl Transferase

Frontiers in Chemistry, 2021
Twelve phosphonopropionates derived from 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid (3-IPEHPC) were synthesized and evaluated for their activity as inhibitors of protein geranylgeranylation.
Damian Kusy, Aleksandra Marchwicka, Joanna Małolepsza, Katarzyna Justyna, Katarzyna Justyna, Edyta Gendaszewska-Darmach, Katarzyna Magdalena Błażewska   +6 more
doaj   +1 more source

Geranylgeranyl pyrophosphate depletion by statins compromises skeletal muscle insulin sensitivity

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Statins are widely prescribed cholesterol‐lowering drugs but have been shown to increase the risk of type 2 diabetes mellitus. However, the molecular mechanisms underlying the diabetogenic effect of statins are still not fully understood ...
Lai Wang, Zuguo Zheng, Lijun Zhu, Lingchang Meng, Hanling Liu, Keke Wang, Jun Chen, Ping Li, Hua Yang   +8 more
doaj   +1 more source