Results 51 to 60 of about 2,762 (157)

Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I.

PLoS ONE, 2011
Small molecule inhibitors of protein geranylgeranyltransferase-I (GGTase-I) provide a promising type of anticancer drugs. Here, we first report the identification of a novel tetrahydropyridine scaffold compound, P61-E7, and define effects of this ...
Lai N Chan, Hannah D G Fiji, Masaru Watanabe, Ohyun Kwon, Fuyuhiko Tamanoi   +4 more
doaj   +1 more source

Dysregulated Cholesterol Metabolism and Its Impact on the Tumour Immune Response in Colorectal Cancer

Journal of Cellular and Molecular Medicine, Volume 29, Issue 15, August 2025.
ABSTRACT Colorectal cancer (CRC) ranks among the primary causes of cancer deaths worldwide. Cholesterol metabolism, tightly regulated through biosynthesis, uptake, efflux and conversion, plays a crucial role in CRC development and progression. Dysregulated cholesterol metabolism in cancer cells alters the tumour microenvironment (TME), promoting tumour
Chunyu Zhang, Zhiwei Miao, Yan Xu, Xingchao Zhu, Tongguo Shi   +4 more
wiley   +1 more source

Development of an image-based screening system for inhibitors of the plastidial MEP pathway and of protein geranylgeranylation [v1; ref status: indexed, http://f1000r.es/4vt]

F1000Research, 2015
We have recently established an in vivo visualization system for the geranylgeranylation of proteins in a stably transformed tobacco BY-2 cell line, which involves expressing a dexamethasone-inducible GFP fused to the prenylable, carboxy-terminal basic ...
Michael Hartmann, Elisabet Gas-Pascual, Andrea Hemmerlin, Michel Rohmer, Thomas J. Bach   +4 more
doaj   +1 more source

Two avian Plasmodium species trigger different transcriptional responses on their vector Culex pipiens

Molecular Ecology, Volume 34, Issue 15, August 2025.
Abstract Malaria is a mosquito‐borne disease caused by protozoans of the genus Plasmodium that affects both humans and wildlife. The fitness consequences of infections by avian malaria are well known in birds, however, little information exists on its impact on mosquitoes.
Marta Garrigós, Guillem Ylla, Josué Martínez‐de la Puente, Jordi Figuerola, María José Ruiz‐López   +4 more
wiley   +1 more source

Development of an image-based screening system for inhibitors of the plastidial MEP pathway and of protein geranylgeranylation [v2; ref status: indexed, http://f1000r.es/5p9]

F1000Research, 2015
In a preceding study we have recently established an in vivo visualization system for the geranylgeranylation of proteins in a stably transformed tobacco BY-2 cell line, which involves expressing a dexamethasone-inducible GFP fused to the prenylable ...
Michael Hartmann, Elisabet Gas-Pascual, Andrea Hemmerlin, Michel Rohmer, Thomas J. Bach   +4 more
doaj   +1 more source

Obesity Affects IVF Outcomes and Mevalonic Acid Rescues the Side Effects of Statins on Follicle Growth

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
Obesity reduces in vitro fertilization pregnancy success, with significant decreases in the number of retrieved oocytes, mature oocytes, and cleavage embryos. Mevalonic acid rescues potential productive toxicity of the lipid‐lowering drug simvastatin in follicular development.
Fei Mao, Jihong Yang, Zhihan Guo, Tianqing Chang, Hua Wu, Guangping Yang, Heqi Dai, Ruizhi Feng, Yun Qian   +8 more
wiley   +1 more source

Human γδ T Cell Function Is Impaired Upon Mevalonate Pathway Inhibition

Immunology, Volume 175, Issue 3, Page 300-322, July 2025.
Mevalonate pathway is important for the effector function of gammadelta T cells. Inhibition of the pathway in vivo and in vitro impairs cytokine and cytotoxic molecule production by mainly affecting protein prenylation and disturbing intracellular signalling in Vdelta2 T cells. Created with Biorender.
Tsz Kin Suen, Burcu Al, Thomas Ulas, Nico Reusch, Harsh Bahrar, Siroon Bekkering, Jaydeep Bhat, Dieter Kabelitz, Joachim L. Schultze, Frank L. van de Veerdonk, Jeanine Roeters van Lennep, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Katarzyna Placek   +14 more
wiley   +1 more source

Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy. [PDF]

PLoS ONE, 2012
The cancer killing efficacy of standard chemotherapeutic agents such as cisplatin (CDDP) is limited by their side effects to normal tissues. Therefore, research efforts optimizing the safety and efficacy of those agents are clinically relevant.
Yandong Shi, Emanuela Felley-Bosco, Thomas M Marti, Rolf A Stahel   +3 more
doaj   +1 more source

Zoledronic acid inhibits TSC2-null cell tumor growth via RhoA/YAP signaling pathway in mouse models of lymphangioleiomyomatosis

Cancer Cell International, 2020
Background This study is to investigate the effects of zoledronic acid (ZA) on TSC2-null cell proliferation and on the tumor progression and recurrence in mouse models of lymphangioleiomyomatosis (LAM).
Dandan Zhao, Jing Wu, Yinjuan Zhao, Wei Shao, Qi Cheng, Xiaoyan Shao, Xianwen Yuan, Juan Ye, Jianpu Gao, Meiling Jin, Chaojun Li, Xiaolin Chen, Yue Zhao, Bin Xue   +13 more
doaj   +1 more source

Quantitative Proteomic Analysis Indicates That Pggt1b Deficiency Promotes Cytokine Secretion in Resiquimod‐Stimulated Bone Marrow‐Derived Macrophages via the NF‐κB Pathway

Immunity, Inflammation and Disease, Volume 13, Issue 4, April 2025.
In Pggt1b‐deficient macrophages, TLR4 may be in a highly activated state and can be activated by R848 or DAMPS, which strongly correlated with increased cytokine production, interferon‐γ production, augmented amide binding and transferase activity, and the activation of NF‐κB and/or Nlrp3 inflammasome pathways.
Shanshan Yu, Xuecui Wei, Fangyuan Long, Heng Gu, Zhimin Hao   +4 more
wiley   +1 more source