Results 61 to 70 of about 2,762 (157)

RABGGTB plays a critical role in ALS pathogenesis

Brain Research Bulletin
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with unknown causes, which mainly affects motor neurons in the anterior horn of the spinal cord, brain stem, and cerebral cortex, also known as motor neuron disease.
Haiyang Ma, Jia Huo, Cheng Xin, Jing Yang, Qi Liu, Hui Dong, Rui Li, Yaling Liu   +7 more
doaj   +1 more source

Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells

BMC Cancer, 2006
Background Nitrogen-containing bisphosphonates (N-BPs) have been designed to inhibit osteoclast-mediated bone resorption. However, it is now accepted that part of their anti-tumor activities is related to interference with the mevalonate pathway. Methods
Weinbaum Carolyn, Faye JC, Lajoie-Mazenc I, Pradines A, Thoulouzan M, Goffinet M, Séronie-Vivien S   +6 more
doaj   +1 more source

Examining Farnesyltransferase Interaction With Cell‐Permeable CaaX Peptides and the Role of the CaaX Motif in Biological Activity

Journal of Peptide Science, Volume 31, Issue 4, April 2025.
This work examines the interaction between farnesyltransferase (FTase) and cell‐permeable CaaX peptides. Particularly, peptide CaaX‐1 is presented as efficient binder to FTase capable to inhibit further interaction of other CaaX motif–bearing peptides. Moreover, biological effects require an intact CaaX motif.
Merlin Klußmann, Jan Reuter, Christian Werner, Ines Neundorf   +3 more
wiley   +1 more source

Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy

Cell Reports, 2015
Balance between cell growth and proliferation determines cell size homeostasis, but little is known about how metabolic pathways are involved in the maintenance of this balance.
Teemu P. Miettinen, Mikael Björklund
doaj   +1 more source

Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases

Microbiology and Immunology, Volume 69, Issue 4, Page 191-202, April 2025.
ABSTRACT Supersulfides are molecular species characterized by catenated sulfur moieties, including low‐molecular‐weight and protein‐bound supersulfides. Emerging evidence suggests that these molecules, abundantly present in diverse organisms, play essential roles far beyond their chemical properties, such as functions in energy metabolism, protein ...
Tianli Zhang, Touya Toyomoto, Tomohiro Sawa, Takaaki Akaike, Tetsuro Matsunaga   +4 more
wiley   +1 more source

Multifunctional Nanomaterials Mediate Cholesterol Depletion for Cancer Treatment

Angewandte Chemie, Volume 136, Issue 46, November 11, 2024.
In this minireview, we briefly discuss multiple roles of cholesterol in cancer progression, tumor microenvironment, and immune responses. We then summarize recent advances in cancer treatment through regulating cholesterol metabolism using multifunctional nanomaterials, via oxidative stress regulation, immune checkpoint modulation, mechanical stress ...
Wenyao Zhen, Tomas Germanas, Ralph R. Weichselbaum, Wenbin Lin   +3 more
wiley   +1 more source

Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.

PLoS Biology, 2014
Vesicular trafficking plays a key role in tuning the activity of Notch signaling. Here, we describe a novel and conserved Rab geranylgeranyltransferase (RabGGT)-α-like subunit that is required for Notch signaling-mediated lateral inhibition and cell fate
Wu-Lin Charng, Shinya Yamamoto, Manish Jaiswal, Vafa Bayat, Bo Xiong, Ke Zhang, Hector Sandoval, Gabriela David, Stephen Gibbs, Hsiang-Chih Lu, Kuchuan Chen, Nikos Giagtzoglou, Hugo J Bellen   +12 more
doaj   +1 more source

Rab geranylgeranylation occurs preferentially via the pre-formed REP–RGGT complex and is regulated by geranylgeranyl pyrophosphate

Biochemical Journal, 2008
Prenylation (or geranylgeranylation) of Rab GTPases is catalysed by RGGT (Rab geranylgeranyl transferase) and requires REP (Rab escort protein). In the classical pathway, REP associates first with unprenylated Rab, which is then prenylated by RGGT. In the alternative pathway, REP associates first with RGGT; this complex then binds and prenylates Rab ...
Baron, Rudi A., Seabra, Miguel C
openaire   +3 more sources

Towards Complete Sets of Farnesylated and Geranylgeranylated Proteins

PLoS Computational Biology, 2005
Three different prenyltransferases attach isoprenyl anchors to C-terminal motifs in substrate proteins. These lipid anchors serve for membrane attachment or protein-protein interactions in many pathways. Although well-tolerated selective prenyltransferase inhibitors are clinically available, their mode of action remains unclear since the known ...
Maurer-Stroh, Sebastian, Koranda, Manfred, Benetka, Wolfgang, Schneider, Georg, Sirota Leite, Fernanda, Eisenhaber, Frank   +5 more
openaire   +5 more sources

Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic β-Cells

Cellular Physiology and Biochemistry, 2016
Background/Aims: At least 300 prenylated proteins are identified in the human genome; the majority of which partake in a variety of cellular processes including growth, differentiation, cytoskeletal organization/dynamics and vesicle trafficking. Aberrant
Rajakrishnan Veluthakal, Daleep K. Arora, Marc L. Goalstone, Renu A. Kowluru, Anjaneyulu Kowluru   +4 more
doaj   +1 more source