Results 71 to 80 of about 2,762 (157)

Inhibition of protein geranylgeranylation and farnesylation protects against graft-versus-host disease via effects on CD4 effector T cells

Haematologica, 2013
Despite advances in immunosuppressive regimens, acute graft-versus-host disease remains a frequent complication of allogeneic hematopoietic cell transplantation.
Anne-Kathrin Hechinger, Kristina Maas, Christoph Dürr, Franziska Leonhardt, Gabriele Prinz, Reinhard Marks, Ulrike Gerlach, Maike Hofmann, Paul Fisch, Jürgen Finke, Hanspeter Pircher, Robert Zeiser   +11 more
doaj   +1 more source

Inhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity.

PLoS ONE, 2013
BackgroundSmall GTPases (guanosine triphosphate, GTP) are involved in many critical cellular processes, including inflammation, proliferation, and migration.
Hongbing Xiao, Xiong Qin, Ding Ping, Keqiang Zuo   +3 more
doaj   +1 more source

Human Geranylgeranyl Diphosphate Synthase [PDF]

Journal of Biological Chemistry, 1999
Tsuyoshi Kuzuguchi, Yuiko Morita, Ikuko Sagami, Hiroshi Sagami, Kyozo Ogura   +4 more
openaire   +1 more source

Liposomal simvastatin potentiates intranasal H1N1 influenza subunit vaccine via increasing transcytosis of antigen and submucosal dendritic cell recruitment

Acta Pharmaceutica Sinica B
Intranasal vaccines specifically eliciting mucosal immunity in the upper respiratory tract have shown advantages in protecting against respiratory virus invasion.
Afeng Yang, Chen Zhang, Aihua Wu, Jiaojiao Xu, Hongzheng Lin, Zhe Li, Tingting Li, Yunlu Li, Ningshao Xia, Xunlong Shi, Tianying Zhang, Wei Lu   +11 more
doaj   +1 more source

Pyrin inflammasome-driven erosive arthritis caused by unprenylated RHO GTPase signaling

EMBO Molecular Medicine
Geranylgeranyl pyrophosphate, a non-sterol intermediate of the mevalonate pathway, serves as the substrate for protein geranylgeranylation, a process catalyzed by geranylgeranyl transferase I (GGTase-I).
Murali K Akula, Elisabeth Gilis, Pieter Hertens, Lieselotte Vande Walle, Mozes Sze, Julie Coudenys, Yunus Incik, Omar Khan, Martin O Bergo, Dirk Elewaut, Andy Wullaert, Mohamed Lamkanfi, Geert van Loo   +12 more
doaj   +1 more source

Geranylgeranyl Transferase [PDF]

, 2020
openaire   +1 more source

Corrigendum: A Requirement of Protein Geranylgeranylation for Chemokine Receptor Signaling and Th17 Cell Function in an Animal Model of Multiple Sclerosis

Frontiers in Immunology, 2021
Gregory Swan, Gregory Swan, Jia Geng, Eunchong Park, Quanquan Ding, John Zhou, Ciana Walcott, Junyi J. Zhang, Hsin-I. Huang, Gianna Hammer, Donghai Wang, Donghai Wang   +11 more
doaj   +1 more source

Evaluating protein prenylation of human and viral CaaX sequences using a humanized yeast system

Disease Models & Mechanisms
Emily R. Hildebrandt, Anushka Sarkar, Rajani Ravishankar, June H. Kim, Walter K. Schmidt   +4 more
doaj   +1 more source

Organotellurium Probes Enable One-step Single-cell Analysis of Post-translational Modification. [PDF]

J Am Chem Soc
Chen Y, Elbein K, Venkatachalapathy S, Lorimer EL, Sprague-Getsy AM, Auger SA, Maxwell ZA, Rashidian M, Hougland JL, Williams CL, Arriaga EA, Distefano MD.   +11 more
europepmc   +1 more source

Impact of protein prenylation inhibition on Mycobacterium leprae viability and IL-1β production in infected macrophages. [PDF]

J Bacteriol
da Silva Rocha M, Rodrigues Pereira AM, Freire Dos Santos PM, Alves Dias A, Pontes Pereira M, Sammarco Rosa P, Bertoluci DFF, Belisle JT, Ramalho Costa FdM, de Macedo CS, Vidal Pessolani MC, Berrêdo-Pinho M.   +11 more
europepmc   +1 more source